Displaying items by tag: ledipasvir
Sofosbuvir Ledipasvir NMR and Mass Spec
We were quite excited to see the first shipment of Chinese sourced Sofosbuvir and Ledipasvir. A white powder and and off white powder, but what would the NMR show? Here's the NMR for Sofosbuvir which is right on the money.
Ledipasvir: mass [M+H] + 889.4195 ( < 2 ppm error)
- molecular formula - C49H54F2N8O6
Sofosbuvir: mass [M+H] + 530.1699 ( < 0.2 ppm error)
- molecular formula - C22H29FN3O9P
Drug Safety Update: Risks of severe bradycardia and heart block when taken with amiodarone
On the 20th May 2015 the Medicines and Healthcare products Regulatory Agency in the UK issued a Drug Safety Update titled:
Sofosbuvir with daclatasvir; sofosbuvir and ledipasvir: risks of severe bradycardia and heart block when taken with amiodarone.
You will find a link to it at:
WHO moves to improve access to lifesaving medicines for hepatitis C
GENEVA - WHO today published the new edition of its Model List of Essential Medicines which includes ground-breaking new treatments for hepatitis C.
http://www.who.int/mediacentre/news/releases/2015/new-essential-medicines-list/en/