TOPIC: Please check for medication interactions (+ website link)

Like many medications the new Hep C medications can interact with other medications you might be taking.

Please use this site to check is any medications you're on will interact with medications you're planning to take.

www.hep-druginteractions.org/checker

Hi James

Could you please explain how one would manage being on setraline/zoloft when commencing treatment of sofosbruvir and daclatsavir? I've checked out the interactions table and still don't understand the ramifications? I guess I'm asking for myself who has remained on this AD since my last treatment and for all hepers, as many would be in the same situation. If there is any question on interaction I'd like to wean off the AD prior to commencing, maybe? Em

Edit: I'm on 50mg daily, well most days when I remember!

www.hep-druginteractions.org/checker

So if you go through the process and

• tick Sofosbuvir + Daclatasvir on the first page,
• next
• the alphabetical search is the default
• next
• then find and tick Sertraline
• scroll down to finish
• you will see the "potential interaction".

You can get a PDF of that as well.

However if you go and look at some of the research you can be reassured to find:

Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers.

Which says:

These results demonstrate in vivo that, unlike nefazodone, venlafaxine, sertraline, and fluoxetine do not possess significant metabolic inductive or inhibitory effects on CYP3A4.

So you're good to take the 60 mg Daclatasvir dose, rather than have to reduce to 30 mg or stop the problem medication.

Thanks James

I was looking at another interactions document and also saw this one but didn't realise it was a 'tool' as such. Thank you. Em

I'm allergic to certain food (strawberries, citrus fruit, chocolate) and penicillin. Do I need an allergy test before going OS Dac+Sof or Harvoni treatment. If yes what ingredients should be tested?

You should be fine Dan. Here are the ingredients for:

Sovaldi


Tablet core

Sofosbuvir
Mannitol (E421)
Microcrystalline cellulose (E460)
Croscarmellose sodium
Colloidal anhydrous silica (E551)
Magnesium stearate (E470b)

Film-coating

Polyvinyl alcohol (E1203)
Titanium dioxide (E171)
Macrogol 3350 (E1521)
Talc (E553b)
Yellow iron oxide (E172)

Daklinza

Tablet core

Daclatasvir
Anhydrous lactose
Microcrystalline cellulose
Croscarmellose sodium
Silicon dioxide (E551)
Magnesium stearate

Tablet film-coat

Hypromellose
Titanium dioxide (E171)
Macrogol 400
Indigo carmine aluminum lake (E132)
Yellow iron oxide (E172)

Harvoni

Tablet core

Sofosbuvir
Ledipasvir
Copovidone
Lactose monohydrate
Microcrystalline cellulose
Croscarmellose sodium
Colloidal anhydrous silica
Magnesium stearate

Film-coating

Polyvinyl alcohol
Titanium dioxide
Macrogol 3350
Talc
Sunset yellow FCF aluminium lake (E110)

Just put any of those fancy names into Google to find out what they are and what they do.

Can anyone tell me if CT contrast fluid iohexol would interfer with anti virals sof,dacl&riba. I looked up the chart but iohexol isn't listed. kindly

Thanks berrinice, hadn't thought of that but something I also need to know for when my meds arrive.

It will not cause any problems with your medication. The 1/2 life is 2 hours so the levels in your blood look like

0 1
2 1/2
4 1/4
6 1/8
8 1/16
10 1/32
12 1/64
14 1/128
16 1/256
18 1/512
20 1/1024
22 1/2048
24 1/4096

etc. In other words it takes very little time to get rid of it from your system.

Does anyone know whether you can take Alpha Lipoic Acid (Antioxidant) on treatment?

Dear all, Me again !

Still asking about the Alpha Lipoic Acid - Have taken this on initial diagnosis, VL and bloods came right down, although this could also have something to do with a seriously healthy eating plan.

Stopped taking it for a while (it's quite expensive) - VLwent up and bloods worsened, including Alt 61- 114.

Am currently back on it - Alt back down to 76, last VL 900,000, waiting on latest VL result.

but my question remains, does anyone know if I can continue with taking ALA when on treatment?

Best wishes to all

Hi LG. Dr Freeman answered your questions in a separate thread.

fixhepc.com/forum/experts-corner/534-supplements-with-evidence.html

Where do you buy it from H&B?

Hi Dan, Thanks, have just seen that - Great news. Think I sent you this info / links a while ago? but prob too many emails ago now I would imagine!

I have been advised against H & B by a medical/scientific herbalist - I only use Lamberts, you can google them , they are online. They definitely seem to help me anyway and started the B12 again, pulsating feeling seems to have calmed down too, could be coincidence, then again it might be as a result

I do know that ages ago I did some very thorough research before buying and advising, read medical papers etc

Warm wishes to you and hope the eczema starts to clear soon.

Yes, I have the link. Which one do you normally buy?

It is recommended that you take 200 mgs 3 times a day, but I couldn't find 200 mg tabs, so I sometimes take 1 x 300 mgs 'super strength' and sometimes 2 . One morning and one night.