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WCC DOUBLED 7 years 10 months ago #17697
| Has anyone experienced their WCC increasing after completing DAA treatment ? Start of treatment WCC 8.4, neut 3.18, lymph 4.26 EOT 6 weeks WCC 16.3, neut 7.68, lymph 7.53 ????? AUSTRALIAN HCV Genotype 1a 2003 Relapsed Peg Interferon / Ribavirin Pre treatment VL 2,000,000 ALT 65, AST 42, ALP 111, GGT 56 Bridging F3-4 Treatment -24 weeks - Sof , Led with 12 weeks Riba. 4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14 12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20 24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14 EOT 6th April 2016 SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20 |
WCC DOUBLED 7 years 10 months ago #17700
Hi Michael, As discussed this is something that needs hematology review. YMMV | |
WCC DOUBLED 7 years 10 months ago #18152
| Thanks Dr James, Will update after seeing Haemotologist tomorrow. AUSTRALIAN HCV Genotype 1a 2003 Relapsed Peg Interferon / Ribavirin Pre treatment VL 2,000,000 ALT 65, AST 42, ALP 111, GGT 56 Bridging F3-4 Treatment -24 weeks - Sof , Led with 12 weeks Riba. 4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14 12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20 24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14 EOT 6th April 2016 SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20 |
WCC DOUBLED 7 years 10 months ago #18593
| Had all my blood tests done & seen my haematologist the other day. He told me that I have very early stage Chronic Lymphoma Lukemia. This can be brought on by HCV or just being a male over 60. Let's hope my SVR 12 comes in undetected next week. Australian Geno type 1a Fibrosis 3-4 Treatment experienced Peg-Interferon Ribavirin (Relapsed) Started 22/10/15 DAA's 24 weeks Sofosbuvir Ledisbovir & 12 weeks Ribavirin Viral Load at week 4 <15 Detected Viral Load at week 12 Undetected Viral Load at week 24 Undetected Viral Load SVR4 Undetected Viral Load SVR12 Undetected |
WCC DOUBLED 7 years 10 months ago #18649
Tough news Michael, not fair to have slayed one dragon and have another appear. From hobbit land I hope you do a Baggins on it and out manoeuvre. Best of luck for your SVR coming up too. Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716 | |
WCC DOUBLED 7 years 10 months ago #18650
One dragon at a time, Michael. Hopefully its one down and one to go. Wishing good things for you. Fitz Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016 2 Week Results 20 June, 2016 AST 19, ALT 32 4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35 6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15 8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND 12 Week Results 31 August, 2016 LFTs Normal, VL = UND EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4" SVR12, 21 Nov 2016. CURED!!! The following user(s) said Thank You: Ariel | |
WCC DOUBLED 7 years 10 months ago #18658
| Thanks guys for the thoughts & encouragement . Yes, one dragon at a time lol. It was interesting to see the link between HCV & Chronic Lymphocytic Leukemia (CLL) The good thing is, that not everyone that has HCV will contract CLL . (Only me One thing I found out from my haematologist, was that CLL is very hard to treat if you have the hepC virus. So it's starting to be very important for me to clear this virus before I need treatment for the CLL . There's only about 1% that reach the point in needing treatment in the first year. The rest could be somewhere up until 10 years later. ( let's hope that's where I am) Having my SVR 12 blood test done tomorrow. Boy!!!!! Is that 12 day wait for the results going to feel like a lifetime. Australian Geno type 1a Fibrosis 3-4 Treatment experienced Peg-Interferon Ribavirin (Relapsed) Started 22/10/15 DAA's 24 weeks Sofosbuvir Ledisbovir & 12 weeks Ribavirin Viral Load at week 4 <15 Detected Viral Load at week 12 Undetected Viral Load at week 24 Undetected Viral Load SVR4 Undetected Viral Load SVR12 Undetected |
WCC DOUBLED 7 years 10 months ago #18660
| Hi Michael, I'm sorry to hear of this development. I hope your SVR 12 comes back positive. Then onward to defeating this problem too. Gt 1a, F0, VL 6.5 million, AST 59, ALT 62 Started Twinvir 1/15/16 6 wk. labs VL UND, AST 27, ALT 20 EOT labs VL UND, AST 23, ALT 19 SVR 16, VL UND, AST 28, ALT 17 SVR 24 , VL UND, 10/8/16 SVR 125, VL UND, 9/22/18 SVR 230, VL UND, 10/3/20 The following user(s) said Thank You: fitz |
WCC DOUBLED 7 years 10 months ago #18664
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Thanks GF, I know what you mean, but I would like my result to be negative Australian Geno type 1a Fibrosis 3-4 Treatment experienced Peg-Interferon Ribavirin (Relapsed) Started 22/10/15 DAA's 24 weeks Sofosbuvir Ledisbovir & 12 weeks Ribavirin Viral Load at week 4 <15 Detected Viral Load at week 12 Undetected Viral Load at week 24 Undetected Viral Load SVR4 Undetected Viral Load SVR12 Undetected The following user(s) said Thank You: Matt-Kenney-google, fitz |
WCC DOUBLED 7 years 10 months ago #18665
| Yes negative for VL, so a positive Sustained Viral Response! Gt 1a, F0, VL 6.5 million, AST 59, ALT 62 Started Twinvir 1/15/16 6 wk. labs VL UND, AST 27, ALT 20 EOT labs VL UND, AST 23, ALT 19 SVR 16, VL UND, AST 28, ALT 17 SVR 24 , VL UND, 10/8/16 SVR 125, VL UND, 9/22/18 SVR 230, VL UND, 10/3/20 |
WCC DOUBLED 7 years 10 months ago #18673
| yes of course GF. Sorry I got that arse about I've just been looking for "negitive" PCR RNA VL results for the 24 weeks of treatment. Never thought of looking at SVR as a positive result. Positive attitude , Positive outlook, Positive result. Australian Geno type 1a Fibrosis 3-4 Treatment experienced Peg-Interferon Ribavirin (Relapsed) Started 22/10/15 DAA's 24 weeks Sofosbuvir Ledisbovir & 12 weeks Ribavirin Viral Load at week 4 <15 Detected Viral Load at week 12 Undetected Viral Load at week 24 Undetected Viral Load SVR4 Undetected Viral Load SVR12 Undetected |
WCC DOUBLED 7 years 10 months ago #18676
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2 22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve) 10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India 09/05/16: ALT 34, VL: NOT Detected 17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72 | |
WCC DOUBLED 7 years 10 months ago #18687
And if you do end up needing treatment Rituximab is about to arrive as a bio similar so you could avoid the harsh routine chemo and do generics #2 YMMV | |
WCC DOUBLED 7 years 10 months ago #18688
| Well Micheal, just getting a new day started here in the US and now eagerly awaiting your test results... I'm sure not as eagerly as you, but none the less, we're like family here. What affects one affects all GT1a; Got it some time in the 70's; Diagnosed @1976 Tx naive METAVIR: A2-F2 SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000 3 weeks after SOT: AST 27 ALT 31 VL 138 Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24 Hep C RNA "NOT DETECTED" AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24! |
WCC DOUBLED 7 years 10 months ago #18696
| Hi Michael Im sorry to hear of this news - talk about a bump in the road. Ive got my fingers and toes crossed for a SVR 12 to grace your path report. T SVR 24 |
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