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End of Treatment - EOT
WCC DOUBLED
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WCC DOUBLED 7 years 10 months ago #17697

Has anyone experienced their WCC increasing after completing DAA treatment ?
Start of treatment WCC 8.4, neut 3.18, lymph 4.26
EOT 6 weeks WCC 16.3, neut 7.68, lymph 7.53
?????
AUSTRALIAN
HCV Genotype 1a
2003 Relapsed Peg Interferon / Ribavirin
Pre treatment VL 2,000,000
ALT 65, AST 42, ALP 111, GGT 56
Bridging F3-4
Treatment -24 weeks - Sof , Led with 12 weeks Riba.
4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14
12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20
24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14
EOT 6th April 2016
SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20
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WCC DOUBLED 7 years 10 months ago #17700

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Hi Michael,

As discussed this is something that needs hematology review.
YMMV
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WCC DOUBLED 7 years 10 months ago #18152

Thanks Dr James,
Will update after seeing Haemotologist tomorrow.
AUSTRALIAN
HCV Genotype 1a
2003 Relapsed Peg Interferon / Ribavirin
Pre treatment VL 2,000,000
ALT 65, AST 42, ALP 111, GGT 56
Bridging F3-4
Treatment -24 weeks - Sof , Led with 12 weeks Riba.
4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14
12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20
24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14
EOT 6th April 2016
SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20
The following user(s) said Thank You: Ariel, Meg, fitz

WCC DOUBLED 7 years 9 months ago #18593

Had all my blood tests done & seen my haematologist the other day.
He told me that I have very early stage Chronic Lymphoma Lukemia.
This can be brought on by HCV or just being a male over 60.
Let's hope my SVR 12 comes in undetected next week. :)
Australian
Geno type 1a
Fibrosis 3-4
Treatment experienced Peg-Interferon Ribavirin (Relapsed)
Started 22/10/15 DAA's 24 weeks Sofosbuvir Ledisbovir & 12 weeks Ribavirin
Viral Load at week 4 <15 Detected
Viral Load at week 12 Undetected
Viral Load at week 24 Undetected
Viral Load SVR4 Undetected
Viral Load SVR12 Undetected
The following user(s) said Thank You: pat1, Ariel, Hieupham, fitz

WCC DOUBLED 7 years 9 months ago #18649

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Tough news Michael, not fair to have slayed one dragon and have another appear. From hobbit land I hope you do a Baggins on it and out manoeuvre. Best of luck for your SVR coming up too.
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
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WCC DOUBLED 7 years 9 months ago #18650

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One dragon at a time, Michael. Hopefully its one down and one to go. Wishing good things for you.

Fitz
Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!
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WCC DOUBLED 7 years 9 months ago #18658

Thanks guys for the thoughts & encouragement .
Yes, one dragon at a time lol.
It was interesting to see the link between HCV & Chronic Lymphocytic Leukemia (CLL)
The good thing is, that not everyone that has HCV will contract CLL . (Only me :) )
One thing I found out from my haematologist, was that CLL is very hard to treat if you have the hepC virus.
So it's starting to be very important for me to clear this virus before I need treatment for the CLL .
There's only about 1% that reach the point in needing treatment in the first year. The rest could be somewhere up until 10 years later. ( let's hope that's where I am)
Having my SVR 12 blood test done tomorrow. Boy!!!!! Is that 12 day wait for the results going to feel like a lifetime.
Australian
Geno type 1a
Fibrosis 3-4
Treatment experienced Peg-Interferon Ribavirin (Relapsed)
Started 22/10/15 DAA's 24 weeks Sofosbuvir Ledisbovir & 12 weeks Ribavirin
Viral Load at week 4 <15 Detected
Viral Load at week 12 Undetected
Viral Load at week 24 Undetected
Viral Load SVR4 Undetected
Viral Load SVR12 Undetected
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WCC DOUBLED 7 years 9 months ago #18660

Hi Michael, I'm sorry to hear of this development. I hope your SVR 12 comes back positive. Then onward to defeating this problem too. :cheer: :+1:
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
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WCC DOUBLED 7 years 9 months ago #18664

Greedfighter wrote: Hi Michael, I'm sorry to hear of this development. I hope your SVR 12 comes back positive. Then onward to defeating this problem too. :cheer: :+1:


Thanks GF, I know what you mean, but I would like my result to be negative :) :)
Australian
Geno type 1a
Fibrosis 3-4
Treatment experienced Peg-Interferon Ribavirin (Relapsed)
Started 22/10/15 DAA's 24 weeks Sofosbuvir Ledisbovir & 12 weeks Ribavirin
Viral Load at week 4 <15 Detected
Viral Load at week 12 Undetected
Viral Load at week 24 Undetected
Viral Load SVR4 Undetected
Viral Load SVR12 Undetected
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WCC DOUBLED 7 years 9 months ago #18665

Yes negative for VL, so a positive Sustained Viral Response! :cheer: :+1:
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
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WCC DOUBLED 7 years 9 months ago #18673

yes of course GF.
Sorry I got that arse about :)
I've just been looking for "negitive" PCR RNA VL results for the 24 weeks of treatment.
Never thought of looking at SVR as a positive result.
Positive attitude , Positive outlook, Positive result.
:) :) :) :) :)
Australian
Geno type 1a
Fibrosis 3-4
Treatment experienced Peg-Interferon Ribavirin (Relapsed)
Started 22/10/15 DAA's 24 weeks Sofosbuvir Ledisbovir & 12 weeks Ribavirin
Viral Load at week 4 <15 Detected
Viral Load at week 12 Undetected
Viral Load at week 24 Undetected
Viral Load SVR4 Undetected
Viral Load SVR12 Undetected
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WCC DOUBLED 7 years 9 months ago #18676

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Hi Michael

Love your attitude to your latest diagnosis of CLL ... it's just another hurdle you'll jump over.

Good luck tomorrow. Keep busy, and hopefully the next 12 days will fly by and we will all be celebrating with you on your SVR 12 result.

I've got my fingers crossed for you.



Cheers

GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected :cheer: :) , FBG 11.9 :huh:
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
:) (Accu-Chek Mobile & Omron Auto BP Monitor) :)
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WCC DOUBLED 7 years 9 months ago #18687

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And if you do end up needing treatment Rituximab is about to arrive as a bio similar so you could avoid the harsh routine chemo and do generics #2
YMMV
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WCC DOUBLED 7 years 9 months ago #18688

Well Micheal, just getting a new day started here in the US and now eagerly awaiting your test results... I'm sure not as eagerly as you, but none the less, we're like family here. What affects one affects all :) so, good, positively negative results on svr12 today my brother ... and cheering you on to victory in the battle ahead. :+1:
GT1a; Got it some time in the 70's; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA "NOT DETECTED"
AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24!
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WCC DOUBLED 7 years 9 months ago #18696

Hi Michael Im sorry to hear of this news - talk about a bump in the road. Ive got my fingers and toes crossed for a SVR 12 to grace your path report.

T
SVR 24
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