100% - Dare to Dream The Impossible Dream
The combination of Sofosbuvir and Daclatasvir provided pangenotyic treatment of HVC by inhibiting NS5B and NS5A.
Simeprevir inhibits the NS3A/4 components: en.wikipedia.org/wiki/Simeprevir
If you've been wondering if inhibiting NS3A/4 + NS5A + NS5B might work really well consider the IMPACT study that was reported at the AASLD November 2015 meeting - 100% might well be here:
File Attachment:File Name: AASLD_IMPACTStudy.pdf
File Size:755 KB
Before you get too excited there is no generic Simeprevir currently available and the cheapest price you might find it is for $7500 USD for 3x28 in Egypt, but it does look very promising.
Note that Simeprevir is not active against GT3 and you don't want the Q80K mutation