So 6.6% dropping to 1.9% may indicate an increased initial risk followed by a rapid decline....or it may just be within the normal spread of statistical data over any period of time.
Yes, I am not sure about this too. Drugs are under review by european regulator now, and, hope, we will have some decision and additional information in near future. Personally, I decided to wait, at least several months. Of course, I had read fixhepc.com/forum/experts-corner/320-why...edications.html#2770
- but this posting was written before emerging of data of possibly increased risk of HCC occurence/recurrence shortly after DAA treatment with cirrhosis. If there is an increased possibility (for example, 1:13 chance) of getting HCC in first year after treatment, then decision looks not so obvious for my situation ("well-compensated" cirrhosis during 10 years).
Then have a look at the graph marked DC below that one which shows a large and continuing decrease in the rates of liver decompensation for this same group of patients...
Yes. But if we will focus on question whether benefits of treatment outweigh harm or not, probably, we need to take into account that treatment itself may cause decompensation in some cases, mostly in sub/decompensated cirrhosis. For example, one study (www.natap.org/2015/EASL/EASL_34.htm
) show that albumin < 35 or age > 65 in Child B or C cirrhosis are associated with more risks than benefits in terms of liver function, measured by MELD score. This may be a cause of recommending treatment after liver transplantation for some patients, for example. Each case is individual...
P.S. If you feel that discussing of possibility of increased HCC occurence (not only HCC recurrence) after DAA treatment in cirrhotics is some "offtopic" in this thread - please feel free to edit my messages.
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91