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Sofosvel (velpatasvir) 6 years 1 month ago #20865

Good luck with it this time round mate.
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
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Sofosvel (velpatasvir) 6 years 1 month ago #20866

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Too right everything that's been said and my support too add it in too Splitdog I am backing you go for it until those buggers have Buggered off :+1:
I'm certain you are charged gladiator style and full on for the conquering ahead
Go Splidog :+1: :+1: :+1:
Love and support from Ariel #flower
Gen 1a
Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas.
pre sof/led VL 240,000 Fibsc F0
Day 25 <30
Day 32 UND
Week 10 UND
EOT UND ALT11AST17GGT19
SVR4 UND ALT10 AST16 GGT13
SVR8 UND ALT <9 AST16 GGT15
SVR12 UND ALT14 AST19 GGT12 Bili 5
EOT +18 ALT13 AST20 GGT9 Bili 5
EOT +21 ALT11AST15
Cured SVR12
Dysplasia Adenomas RemvdAug '16
SVR24 UND ALT11AST16
ColonoscopyClear Nov17
LumpectomyClear ‘18
LithotripsyCytoscopyBiopsy 4/18
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Sofosvel (velpatasvir) 6 years 1 month ago #20871

This is it Splitdog, you're gonna win :cheer: :+1:
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
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Last edit: by Greedfighter.

Sofosvel (velpatasvir) 6 years 1 month ago #20985

Sofosvel came today from Beacon. :) Dr. Freeman recommended I wait until Voxilaprevir becomes available for the triple-cocktail treatment. It will be hard, but I will wait. I recently had a fibroScan test done and I just entered into F3. The shipment from Beacon went smooth as silk. I got a script from Dr. Freeman, which he forwarded to Beacon, then the bank transfer. That was all that was required. It came to the US in 3 days.

:) :cheer: :) :cheer: :) :cheer: :) :cheer: :) :cheer: :P
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
Attachments:
The following user(s) said Thank You: DrJames, coral, pat1, mgalbrai, Ariel, Gaj, Hieupham, re_roll, Hazel, Greedfighter, Murr

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Sofosvel (velpatasvir) 6 years 1 month ago #20987

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Good luck Splitdog although luck isn't even enough I want to say more than just luck it sounds glib and I'm trying to tell you how great this is and thank you for posting the picture and affirming the process.
I love the chillis and glass cleaner and a texas something bottle in the pic what combo was that hahaha (jokes)
This step forward must have helped you feel more confident great to read real stuff real treatment stories and the more testing times should be shared I believe
Backing you Splitdog for cure. Thanks again for the post it will surely give others hope #love
Sending love
Ariel #flower
Gen 1a
Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas.
pre sof/led VL 240,000 Fibsc F0
Day 25 <30
Day 32 UND
Week 10 UND
EOT UND ALT11AST17GGT19
SVR4 UND ALT10 AST16 GGT13
SVR8 UND ALT <9 AST16 GGT15
SVR12 UND ALT14 AST19 GGT12 Bili 5
EOT +18 ALT13 AST20 GGT9 Bili 5
EOT +21 ALT11AST15
Cured SVR12
Dysplasia Adenomas RemvdAug '16
SVR24 UND ALT11AST16
ColonoscopyClear Nov17
LumpectomyClear ‘18
LithotripsyCytoscopyBiopsy 4/18
The following user(s) said Thank You: pat1, Paul-Jarman-facebook, Gaj, splitdog, Hazel

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Sofosvel (velpatasvir) 6 years 1 month ago #20991

So Voxilaprevir is the mysterious GS-9857 which is a Ns3 protease inhibitor like simeprevir I think when is it due out ? I hope it works out for you this time Splitdog.

Cheers
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
The following user(s) said Thank You: pat1, mgalbrai, Ariel, Gaj, splitdog

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Last edit: by Paul-Jarman-facebook.

Sofosvel (velpatasvir) 6 years 1 month ago #20997

Yes, GS-9857. I don't want to hex anything, but the triple combo I believe gave 99% with type 3 previous DAA failures. The first results from phase III trials will be available in January.
Thank you, Paul.
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
The following user(s) said Thank You: pat1, Paul-Jarman-facebook, Gaj, beaches, Hazel

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Last edit: by splitdog.

Sofosvel (velpatasvir) 6 years 1 month ago #20998

Thank you, Ariel. I grow and eat exotic chiles. If I'm not sweating, it ain't hot enough! ;)
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
The following user(s) said Thank You: Ariel

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Last edit: by splitdog.

Sofosvel (velpatasvir) 6 years 1 month ago #20999

Go get 'em, Split!
99%.
I like it!
m
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
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Sofosvel (velpatasvir) 6 years 1 month ago #21002

Should we start a new thread titled 'Vox"?

I found this today:
In summary, administration of multiple doses of GS-9857 was well tolerated and resulted in a robust decline of HCV RNA levels in patients with genotype 1–4 HCV infection. Notably, the potent antiviral activity of GS-9857 was preserved in the presence of commonly observed NS3 mutations associated with resistance to protease inhibitors. GS-9857 demonstrated linear PK when administered at doses ranging from 50 to 300 mg under fasting conditions. The median half-life of GS-9857 ranged from 29 to 42 h, conducive to once-daily dosing. Lastly, GS-9857 has demonstrated additive antiviral activity when evaluated in vitro in combination with sofosbuvir or velpatasvir.[5] Together, these data support the further development of once-daily GS-9857 in combination with other DAAs for the treatment of patients with chronic HCV infection.
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
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Last edit: by splitdog.

Sofosvel (velpatasvir) 6 years 1 month ago #21018

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Awesome pic Splitdog. Best wishes from me for treatment with these new meds. :+1: It was was interesting to read the data that you have put up as well. Beacon came through and so all in all very encouraging news. #flower you have the very best support team in the world with you #love
#duck #duck #duck
#flower #flower #flower
gt 1a VL 6m
F2/3 FibroScan - 9KPa in 2011 and 7KPa in 2015
sof/dac 10 December for 12 weeks
pre tx alt 85 ast 51
4 wk alt 34 ast 31 UND <35
8 wk alt 29 ast 32 UND <15
12wk alt 25 ast 25 EOT 3.3.16
SVR24 UND KPa5.3 F0 in normal range
I am well
.forever grateful to fixhepc
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Last edit: by pat1.

Sofosvel (velpatasvir) 6 years 1 month ago #21022

Thank you Pat and Mike. I can't wait to wage war on these bastards!!! :angry: :P
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
The following user(s) said Thank You: pat1, mgalbrai, Ariel, countless

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Sofosvel (velpatasvir) 6 years 1 month ago #21027

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Ha! Split you can eat those chillies for me! Between Mike with his garlic cloves in Transylvania and you with your chilies you have my food intolerances I have deeveloped post old tx sorted. These two things I now simply cannot eat! No more chilli no more garlic! Once was a lover of both, now my tummy says NO!
I loved you photo.
Have a great spicy flavoured day Splitdog, Happies from Ariel #flower #duck #flower
Gen 1a
Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas.
pre sof/led VL 240,000 Fibsc F0
Day 25 <30
Day 32 UND
Week 10 UND
EOT UND ALT11AST17GGT19
SVR4 UND ALT10 AST16 GGT13
SVR8 UND ALT <9 AST16 GGT15
SVR12 UND ALT14 AST19 GGT12 Bili 5
EOT +18 ALT13 AST20 GGT9 Bili 5
EOT +21 ALT11AST15
Cured SVR12
Dysplasia Adenomas RemvdAug '16
SVR24 UND ALT11AST16
ColonoscopyClear Nov17
LumpectomyClear ‘18
LithotripsyCytoscopyBiopsy 4/18
The following user(s) said Thank You: splitdog

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Sofosvel (velpatasvir) 6 years 1 month ago #21064

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splitdog wrote: Should we start a new thread titled 'Vox"?


:+1: Done, click on link below.

fixhepc.com/forum/relapse-corner/1263-vo...tease-inhibitor.html
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:

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Last edit: by Gaj.

Sofosvel (velpatasvir) 6 years 1 month ago #21072

Vox works best for retreatment. It has gastrointestinal side effects, however it is effective for previous sof failures.
Vel is not very effective for previous sof relapsers, but is recommended for treatment-naive people, because it has no vox-related side effects.
Gen 1b
VL pre treatment 29000 ME/ml
AST 32 ALT 94, F0
Started treatment 13 January 2017
Generic sofosbuvir/velpatasvir (Incepta)
VL 9 days into treatment <300 (undetected)
AST 13.8 ALT 22
Side effects: mild dehydration, not a problem at all if I drink water at night, nothing to worry about
Diet and gastric ph are very important with velpatasvir. One must think what and when to eat to keep gastric pH low. Side effects disappeared 2 weeks after, unless I ate anything < 4hrs before the pill. SVR60.

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Last edit: by vitrus.
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