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Quick question 2 years 3 months ago #24432

  • Janet UK
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Sorry if this has been asked before. I've trawled around and can't find the answer.

Does anyone know how long it takes for Sof/Dac to completely clear from the body after end of treatment?

Thanks and best wishes to all.

Jan
Infected 1981 by contaminated blood products
Geno 3
Interferon/Ribavirin 2009 relapsed after EOT
Generic Sof/Dac started 28 Jan 2017
Baseline VL 24.7 million
UNDETECTED after 26 days.
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Quick question 2 years 3 months ago #24433

  • Gaj
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Hi Janet,

The short answer is that Sofosbuvir has a half life of about one day (27hrs) so the approximate concentration in your body halves each day once you have finished treatment. Eg.

EOT 100%
Day 1. 50%
Day 2. 25%
Day 3. 12%
Day 4. 6%
Day 5. 3%
Day 6. < 2%
Day 7. < 1%

Daclatasvir's half life is 12-15hrs so will clear from your body twice as fast so both these meds are mostly gone from our bodies very quickly. Here is a more detailed explanation from Dr Freeman on how long it takes before Sof/Led are completely gone.

fixhepc.com/forum/experts-corner/872-how...etting-pregnant.html
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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Quick question 2 years 3 months ago #24434

  • Janet UK
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Wow, thanks Gaj! I knew someone on here would come up with the answer. I'm so impressed with the entire generic Hep C meds community. There's always someone, somewhere willing to give their time to answer my questions. I've had far more support than the NHS were willing to give me. Funny that, when it was them who infected me in the first place.

:) :)
Infected 1981 by contaminated blood products
Geno 3
Interferon/Ribavirin 2009 relapsed after EOT
Generic Sof/Dac started 28 Jan 2017
Baseline VL 24.7 million
UNDETECTED after 26 days.
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Quick question 2 years 2 months ago #24550

  • gypsy
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With generic Harvoni I have read you do not want to take caffeine with it as it decreases the efficacy of the medication.
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Quick question 2 years 2 months ago #24554

  • DrJames
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While this site from Gilead suggests limiting caffeine: www.harvoni.com/discover-harvoni/common-side-effects

The official product literature: www.gilead.com/~/media/Files/pdfs/medici...rvoni/harvoni_pi.pdf

Does not mention it.

Caffeine has been shown to delay development of fibrosis and life without coffee would render me dysfunctional and sad so I can find plenty of reasons to go with literature #2 rather than #1
YMMV
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Quick question 2 years 2 months ago #24556

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Phew, that's a relief.......



Aaaaah!!! That's better. :woohoo:


(It appears the recommendation refers to reducing Harvoni side effect of headaches rather than reducing the medication's effectiveness.)
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 2 years 2 months ago by Gaj.
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