The forum is in read only mode.
Welcome, Guest
Username: Password: Remember me
  • Page:
  • 1


FDA Safety announcement AbbVie V Pak 8 years 1 month ago #1627

  • LondonGirl
  • LondonGirl's Avatar Topic Author
  • Offline
  • Platinum Member
  • Platinum Member
  • Posts: 1366
  • Karma: 17
  • Thank you received: 2124

Strangely, my instincts told me not to consider this treatment. Seems rather a jumbled mix of quite a few meds to me which must be a strain on the liver. The irony is, there is a warning of 'severe liver damage' with this treatment. Call me ignorant, but aren't these treatments supposed to be trying to prevent that very thing as part of the intention?
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

FDA Safety announcement AbbVie V Pak 8 years 1 month ago #1628

  • Alsdad
  • Alsdad's Avatar
  • Offline
  • Moderator
  • Moderator
  • Posts: 335
  • Karma: 5
  • Thank you received: 294
There seems to be a 'Goldrush' effect taking place amongst Big Pharma at the moment on HepC meds. :ohmy:

FDA Safety announcement AbbVie V Pak 8 years 1 month ago #1629

The AbbVie trials are batting 100% I believe , my brother in law just finishing 27 weeks on it next week his sfx weren't too bad considering he was quite sick when he started.
Gen 3a Started Sof Dac 16/10/15
V/L 20 Mill +
Hep C pos approx. 27 yrs

Non responder 2011 BMS (dac) Peg Rib

FDA Safety announcement AbbVie V Pak 8 years 1 month ago #1667

  • DrJames
  • DrJames's Avatar
  • Offline
  • Platinum Member
  • Platinum Member
  • Posts: 1980
  • Karma: 111
  • Thank you received: 7263
Most drugs are metabolised by the liver. Even something as routine as Paracetamol/Acetaminophen can be liver toxic - while 2 x 500 mg four times a day is safe, if you take all 20 at once there is a good chance you get liver failure.

So as a rule of thumb many medications are liver toxic at high doses - in effect the liver can not process them fast enough and toxic products build up. A number of promising drugs across many areas have failed in Phase 2/3 trials when patient have got liver failure from them.
  • Page:
  • 1
Time to create page: 0.179 seconds

Copyright © 2015-2020 FixHepC

Back to Top