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REDEMPTION is "Official" in the U.S.!
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REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #8981

  • mgalbrai
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This IS BIG!!!

Way to go Doc!!

www.clinicaltrials.gov/ct2/show/NCT02657...rm=redemption&rank=1
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
The following user(s) said Thank You: DrJames, dointime, Joy, LondonGirl, coral, Vororo, Paul-Jarman-facebook, Gaj, Lynne-Francis-facebook, The_1B_Dude_Abides

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Last edit: by mgalbrai.

REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #8982

:+1: :) Thank you Dr. Freeman.
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James

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REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #8983

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Dr James does it again!
Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
Week4: AST 47, ALT 58. VL < 15 (unquantifiable).
Week12 (EOT): AST 30, ALT 26, VL UND
Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND
Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND
Ever grateful to Dr James.

Relapsed somewhere after all that... Bummer!

Jan 2018: VL 63 000 (still GT3).

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REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #8984

Wow - That 's totally awesome !!
Respect to Dr F :+1:
MonkMed too !
:cheer: :cheer:

Hey, let's not forget the patients on Redemption #love
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
The following user(s) said Thank You: mgalbrai, MonkMed, Hazel

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Last edit: by LondonGirl.

REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #8987

Huge news indeed :woohoo:
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV

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REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #8990

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There it is!! I'm gonna go post this 'somewhere' :P

UPDATE: wow, volleyboss beat me to it!!
eviljoy loves her trials for her followers, she probably doesnt' realize these are the generics she rails against.
GT 2b; since 80's, no prior tx, sofosbuvir and daclatasvir compounded from API's at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. " I feel GOOD!! I knew that I WOULD!"
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Last edit: by 2b.

REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #8992

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I didn't intend to steal your thunder...
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24

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REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #9004

Yes it is big, and in so many ways.

- It is not sponsored by Big Pharma.
- The sof/dac combo will finally get the trial results that have been sorely lacking.
- The generics naysayers will have nowhere to hide.

... and so much more which will no doubt unfold in the fullness of time.

dt

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REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #9006

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This is awesome news and hopefuly will give some US cred to generics and fixhepc. Posting now. Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.
The following user(s) said Thank You: LondonGirl, mgalbrai

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REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #9019

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not at all, funnier than hell I thought when I saw your post there, , im staying far away from it so she doesn't catch on and maybe it will survive longer in her temple of un-reason.
GT 2b; since 80's, no prior tx, sofosbuvir and daclatasvir compounded from API's at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. " I feel GOOD!! I knew that I WOULD!"
The following user(s) said Thank You: mgalbrai, Gaj

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REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #9036

Great news about the Redemption trials in the US!!! :+1:

Do you think it's possible for insurance to pay for it?..(sorry I'm not that familiar with US health insurance policies) :blink:
SVR 24
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Last edit: by Tina-Hill-facebook.

REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #9052

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That is above my pay grade. If I were an insurer, I would be huddling with my legal beagles coming up with a release from liability form for clients to sign who opted for clinical trial treatment coverage.
Since it makes sense, I doubt they will do that.
Mike
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24

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REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #9053

Generally speaking, I have never heard of a medical insurer who would cover "experimental treatment", which is what trials usually come under. They usually only cover treatment approved by the regulatory body, ie. the FDA, NHS, PBS etc. But this is an interesting case because brand name sof, led and dac are all approved drugs. So what category will be applied to the generic sof, led and dac used in this trial?
ie. "experimental" or "approved".

I guess somebody will have to make a claim to find out.
dt

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REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #9062

This is huge!
Forwarded to my dr. and am digitizing my bloods as we speak B)
Thank you for all your hard work, Doctor!
The Dude is damn tired of abiding
Diagnosed 2001
Peg-int + Riba all of 2002, FAIL
Latest bloods 12/29/15:
Sodium, tad low
Glucose, way high
BUN, tad high
SGPT (ALT), 862 (15-78)
SGOT (AST), 283 (9-44)
ALP, 216 (37-127)
B/C ratio, 25.2 (10-20)
Cholesterol, tad low - HDL, good; LDL, 73 (80-130)

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Last edit: by The_1B_Dude_Abides. Reason: eta

REDEMPTION is "Official" in the U.S.! 6 years 10 months ago #9074

dointime wrote: Generally speaking, I have never heard of a medical insurer who would cover "experimental treatment", which is what trials usually come under. They usually only cover treatment approved by the regulatory body, ie. the FDA, NHS, PBS etc. But this is an interesting case because brand name sof, led and dac are all approved drugs. So what category will be applied to the generic sof, led and dac used in this trial?
ie. "experimental" or "approved".

I guess somebody will have to make a claim to find out.
dt


Yeah both yourself and Mike make some good points, when I started treatment I had to sign a disclaimer with my aftercare provider - even though the medication I was taking was on the Med Safe list, much the same as Sof, Led & Dac are approved by the FDA.

I think it would be well worth further investigation.
SVR 24

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