Received my Visa card today and ordered the Harvoni generic for 12 weeks. Not the wait for it begins . If the 12 weeks needs an extension would it be better to take a broader based generic such as Epclusa for the second 12 weeks ? I have be diagnosed with GT 1a but several types can coexist with the dominant GT showing up on the RNA so I am not sure that attacking the known dominant type without ruling out all others is such a good idea.
Harvoni has the best track record of any drug in GT1 with multiple sources of independent validation.
Sof/Vel is new and there are absorption issues around the velpatasvir in some patients. Because it's new, most of the data is company data and the Harvoni data (from the company) was a little on the optimistic side.
We have used quite a lot of Sof/Dac in GT1 and I am aware of a large independent study about to be published about it, but because of the originator price being north of $100k there is less in the public domain.
Any of these are good, and the number of failures so small it's hard to pick a clear winner.
In the end I got treated and got rid of the virus.
Can't remember now if the viral load is/was that significant for treatment in my case - GT3??
Made a difference though when it become undetected!
It's funny that this is all a distant memory now I am free of Hep C.
All the best with your treatment,
GT3a 1990 Failed Inter 1998, comb in 2000. HCC 2012
Started 24/52 Sof/Dac 27th October 2015.
1. Bloods 2 October 2015: AST - 165 (20-40), ALT - 265 (5-40), GGT 189 (5-50)
2, Bloods 20 November 2015: ALT etc normal; VL 19
3. Bloods 8 January 2016: AST - 40, ALT - 59, GGT 48 VL RNA UND
4. EOT 12 April 2016 - blood tests: all is well, CT scan: okay
5. AFP 11 June 2016: 4 ref< 11
6. VL July 2016: DET
7. Oct16 start treat - June17 UND
8. Jun 18, lfts okay, platelets a bit low.
Hello 808cruiser, welcome to the forum! Strange as it may seem, your viral load has very little correlation to cure rate. Patients with high viral loads have the same excellent cure chances as anyone else, 95% for Genotypes 1,2,4,5,6 and 90% for Genotype 3, when treated with the modern direct-acting antiviral medications, or DAAs (e.g. Harvoni®, Epclusa®, etc). Besides, 4 million is not very high, I know FixHepC patients who started treatment with about 30 million viral load and got cured easily. It's common to see a patient with a 16 million viral load go to 1,600 in the first week of treatment, these drugs are remarkably effective. Please this thread of the forum for more on this topic fixhepc.com/forum/fixhepc-admin/1930-viral-load.html#26786 Best of luck to you.
People have higher levels when their immune systems are not doing much. While this might sound bad, the damage from Hep C is driven by the immune response. The little critters don't eat much, so, curious as it may seem, people with a viral load of 10 million are often a lot healthier and less damaged by the Hep C than people with a viral load of 10 thousand where there immune systems are working hard to get rid of the virus and killing lots of liver cells in the process.
Anyway 4 weeks after you start treatment you will have < 15 ...
I know those figures can seem crazy high and worrying but like others my viral load was all over the place before treatment. Anywhere between 1 million and 5+ million and beyond. It doesn't matter much where it is when you start treatment - the most important thing is that those little critters are undetectable at the end.
Good luck with your treatment.
G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24
Finally got a final blood test done and am waiting for the results. A separate CBC showed a change in ALT from 35 to 13 7 months post treatment (Harvoni) and my platelet counts are slowly rising , 132 on the last test and 143 on the most recent. The Hep C results can take 3-4 weeks but they notify your doctor if you have any viral load so no call after 2 weeks is a good sign
While on the treatment my WBC MONOCYTES were at 9.4 which my FD was concerned about but this test put them at 7.0 so I am chalking that up to the Harvoni.