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My twinvir story 6 years 6 months ago #19851

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James-Freeman-facebook wrote: Who says there is no such thing as fairytales.

And Tweakmax lived happily ever after sounds like one to me.


Thanks Doc!

Do you know what is the percentage of people who have svr12 and subsequently go on to svr24? very little percentage will fail svr24 right?
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My twinvir story 6 years 6 months ago #19852

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My doc didn't order SVR24 VL test for me, only fibroscan. She seemed confident about the "cure".

Should I be doing "POOR MAN's VL test" (ALT/AST) every month, just to be sure?
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My twinvir story 6 years 6 months ago #19854

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Data shows that a 12 week is just as accurate as a 24 week test.

But since you'll probably continue to wonder, you could save the money and have a Qualitative Viral Load test at 24 weeks instead of monthly liver enzymes. It gives you a negative or positive result but I believe it's cheaper than a Quantitative test. You can check with the lab in your country.

P.
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My twinvir story 6 years 6 months ago #19855

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I love this part of the story. Congratulations Tweakmax!! #flower #flower
G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24
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My twinvir story 6 years 5 months ago #21250

I found this Tweakmax:

www.hepmag.com/blog/hepatitis-c-treatment-svr

More than 9 out of 10 people will be cured using the current treatments for chronic hepatitis C virus infection. It is thrilling to be told that hepatitis C is no longer detectable in your blood. However, as much as we yearn for those words, sometimes it takes a long time to believe that hepatitis C is gone forever.




The medical term for a successful hepatitis C treatment outcome is sustained viral response (SVR). Undetectable HCV for 24 or more weeks after the end of treatment is an SVR24. Recently, many studies use the term SVR12, meaning that hepatitis C is undetectable for twelve or more weeks after the end of treatment. For those of us had a hard time believing that being viral-free for 24 weeks meant we were cured, then 12 weeks felt unbelievable. Can we trust this?




For most of us, yes. In the January 2015 Hepatology, Eric Yoshida and colleagues reported that there wasn't much difference between an SVR12 and SVR24 among hepatitis C patients who were treated with regimens using sofosbuvir. It didn't matter if interferon was part of the regimen. Analyzing data from studies using sofosbuvir, researchers looked at response rates for genotypes 1 through 6. There were a total of 327 genotypes 1, 4, 5, 6 (mostly genotype 1); 294 genotype 2s; and 250 genotype 3s.




Results

Before presenting the results, there are a couple more terms that are important to understand:

•Relapse was defined as having a negative hepatitis C viral load (HCV RNA) at the end of treatment and subsequently having detectable HCV RNA above the LLOQ.
•In this case, LLOQ is lower limit of quantification, which is the lowest amount of virus that can be precisely counted.

SVR24 was achieved in 777 of 779 patients (99.7%) with SVR12. This means that everyone but two people who achieved an SVR12 had an SVR24. Here's the kicker: the two patients who didn't achieve an SVR 24 both had genotype 3 (both non-cirrhotic, treatment-experienced). Therefore, if you discarded the data for genotype 3 patients and counted everyone else, 100% of those who had an SVR12 had an SVR24. Using viral sequencing, these cases were relapses and not reinfection.
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
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My twinvir story 6 years 5 months ago #21256

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Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
Attachments:
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My twinvir story 6 years 5 months ago #21264

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tweakmax wrote: My doc didn't order SVR24 VL test for me, only fibroscan. She seemed confident about the "cure".

Hi tweakmax,

You already had a happy SVR12 so I wish you a happy SVR24 and only UND!

We are waiting for you in the SV24 club!
#love #love #love
HCV since I don't know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful :)
virus not detected 06.02.2016 & SVR24
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My twinvir story 6 years 4 months ago #21340

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2 more weeks to svr24!
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My twinvir story 6 years 4 months ago #21344

As W said: "Mission Accomplished".
Well done!
Happy for you.
m
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
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My twinvir story 6 years 4 months ago #21363

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Picked up my path request too Tweakmax so hope to shake hands at the SVR24 finish line with you
Happies and bring it on !
Ariel #flower
Gen 1a
Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas.
pre sof/led VL 240,000 Fibsc F0
Day 25 <30
Day 32 UND
Week 10 UND
EOT UND ALT11AST17GGT19
SVR4 UND ALT10 AST16 GGT13
SVR8 UND ALT <9 AST16 GGT15
SVR12 UND ALT14 AST19 GGT12 Bili 5
EOT +18 ALT13 AST20 GGT9 Bili 5
EOT +21 ALT11AST15
Cured SVR12
Dysplasia Adenomas RemvdAug '16
SVR24 UND ALT11AST16
ColonoscopyClear Nov17
LumpectomyClear ‘18
LithotripsyCytoscopyBiopsy 4/18
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My twinvir story 6 years 4 months ago #21427

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thank u one more week to go!
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My twinvir story 6 years 4 months ago #21467

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very encouraged to hear the Romanians on fb, 200 of them cleared their G1b with twinvir!
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My twinvir story 6 years 4 months ago #21468

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Hi Tweakmax,

Very interesting and pleasant news, thank you for sharing it.
Would you perhaps have a link to fb to post here or to send it to me via PM?

I believe it would be a nice information to put also on Twitter :), especially that I've noticed there are not so many articles / information available in Romania about the HCV generic drugs.

Cheers,
RHF
In fiecare an HCV ucide peste 500000 oameni.Medicamentele generice pentru hepatita C functioneaza. Nu deveni statistica! Cauta pe Google “medicamente generice pentru hepatita C”.
HCV kills more than 500000 people every year. HCV generic drugs work. Don't become a statistic.
By sharing this Youtube video you might save someone’s life!
My TX: HEPCVIR-L[generic Harvoni]-India
SVR52 achieved
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My twinvir story 6 years 4 months ago #21555

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A Romanian guy named Vlad rusu told me. Are u on the hep c without borders fb group? There are quite a number of Romanian friends there.
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My twinvir story 6 years 4 months ago #21556

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He told me a lot of Romanians are type 1b hence using twinvir
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