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TOPIC: Transmitting the virus after SVR12?

Transmitting the virus after SVR12? 1 year 2 weeks ago #20119

  • Peach
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James-Freeman-facebook wrote:
Being a pragmatist what we want is cessation of disease progression and symptoms. The evidence to date suggests we do get that, however it's been known since 2004 that you can still find traces of HCV at SVR. That's the reason it gets called SVR rather than cure,

www.ncbi.nlm.nih.gov/pubmed/15140984

For practical purposes SVR is cure - at least for Interferon because we have long term follow up showing SVR is durable and the virus does not come back.

www.sciencedirect.com/science/article/pii/S1413867010700702
www.medscape.com/viewarticle/782532

I spotted this in another thread here on the forum.

Does this mean there's a risk of transmitting the virus to others post SVR12 (+) until there is a way to eliminate these traces through future medical advances?

If I am lucky enough to clear this time around I understand that I should be able to move on with my life and that, for all intents and purposes, the virus is gone and I can start to regain my health.

I certainly won't be offering my razor and toothbrush around to share with everyone, but it does make me sad to think that every time I get a cut or something I could be putting others at risk. The psychological burden of that is really difficult for me to handle.

Also, what about sexual transmission in this case? Is there any cause for concern that the trace RNA could infect my long-term partner? Does this mean we'll have to use a condom indefinitely (for example, risk from microscopic cuts or periods)?

Is there any way one can be tested for trace RNA after achieving SVR? How long do they hang around for? The research papers seem to give conflicting results :dry:


More articles:
www.jci.org/articles/view/73104
www.ncbi.nlm.nih.gov/pubmed/21040725
www.ncbi.nlm.nih.gov/pmc/articles/PMC4608821/
genotype 1a
viral load 160,000
age 29, F0, treatment naive, il28bcc
unable to function due to chronic fatigue, joint/muscle pain, low immune system, depression, anxiety, skin issues, brain fog (etc) : (
12 weeks daclatasvir/sofosbuvir started 11 march 2016 through pbs

week 4 - alt 12
week 12 - viral load undetected
svr12 - NOT DETECTED!
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Transmitting the virus after SVR12? 1 year 2 weeks ago #20121

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Hi Peach,

That's a very good question.
The "traces of HCV" after SVR made someone working in the medical system tell me that I will never get rid of HCV, no matter what treatment I will take (with interferon or without it)...

I am interested as well in finding out the answers to your question.

Cheers
RHF
In fiecare an HCV ucide peste 500000 oameni.Medicamentele generice pentru hepatita C functioneaza. Nu deveni statistica! Cauta pe Google “medicamente generice pentru hepatita C”.
HCV kills more than 500000 people every year. HCV generic drugs work. Don't become a statistic.
By sharing this Youtube video you might save someone’s life!
My TX: HEPCVIR-L[generic Harvoni]-India
SVR52 achieved
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Transmitting the virus after SVR12? 1 year 2 weeks ago #20138

With an HCV viral load, ie pre treatment, sexual transmission with straight sex is extremely unlikely to cause infection. Anal sex is slightly more risky as blood blood contact can occur. Vaginas, penises and mouths have a relatively thick layer of cells that make blood blood contact rare and damage to the defences of both partners needs to be present at the same time.

At SVR there is zero chance of causing infection.
YMMV
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Transmitting the virus after SVR12? 1 year 2 weeks ago #20141

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Hi Peach
I almost certainly contracted HCV in 1975(I got Hep B then) but wasn't diagnosed until 2004.
My partner at the time never got Hep B.
My husband does not have HCV, nor do our children (born in 1990 and 1993)
We unknowingly took risks.
We used the same nail clippers very regularly ;)
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
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Transmitting the virus after SVR12? 1 year 2 weeks ago #20142

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rohcvfighter wrote:
Hi Peach,

That's a very good question.
The "traces of HCV" after SVR made someone working in the medical system tell me that I will never get rid of HCV, no matter what treatment I will take (with interferon or without it)...

I am interested as well in finding out the answers to your question.

Cheers
RHF

Sounds really positive; did they explain how they arrived at this conclusion? Did they means the antibodies?


Jeff
GT3a 1990 Failed Inter 1998, comb in 2000. HCC 2012
Started 24/52 Sof/Dac 27th October 2015.
1. Bloods 2 October 2015: AST - 165 (20-40), ALT - 265 (5-40), GGT 189 (5-50)
2, Bloods 20 November 2015: ALT etc normal; VL 19
3. Bloods 8 January 2016: AST - 40, ALT - 59, GGT 48 VL RNA UND
4. EOT 12 April 2016 - blood tests: all is well, CT scan: okay
5. AFP 16 May 2016: 4 ref <11
6. AFP 11 June 2016: 4 ref< 11
7. VL 4th July 2016: DET
8. ultrasound 12th July 2016 - OK
9. Oct16 start treat - June UND
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Transmitting the virus after SVR12? 1 year 2 weeks ago #20148

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Hi Jeff,

I was getting such opinions from medical staff NOT being specialized in liver diseases.
However, they looked at me like I was a poor and naive person, so any explanation would have been too much for my non-educated brain in medical sciences..... But, in my naivity I continue to hope that the generics killed already the HCV bastards ;-).

P.s. please let's not start a debate about such questionable remarks / advices originating from certain medical staff.... I am pretty sure many of us would have so much to tell :)
In fiecare an HCV ucide peste 500000 oameni.Medicamentele generice pentru hepatita C functioneaza. Nu deveni statistica! Cauta pe Google “medicamente generice pentru hepatita C”.
HCV kills more than 500000 people every year. HCV generic drugs work. Don't become a statistic.
By sharing this Youtube video you might save someone’s life!
My TX: HEPCVIR-L[generic Harvoni]-India
SVR52 achieved
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Transmitting the virus after SVR12? 1 year 2 weeks ago #20152

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I fathered two daughters even with a vl of 1.9 million. My wife is hcv free. With svr12, I am sure the chances of spreading=zero
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Transmitting the virus after SVR12? 1 year 2 weeks ago #20165

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Thank you Dr Freeman for your reply in this topic
I asked this question myself of my public hospitals specialist and my treatment GP when I reached SVR12
I have been assured there is zero way a non active, undetected virus can be transmitted, as there's nothing to transmit; this is what I was told.
I have two children and no vertical transmission ever occurred.
I too have shared nail clippers etc as others here mention and nobody else has contracted hcv in my immediate family, and neither do I have it either now Thankyou to the generic medicines.
Sure, there will be a marker to say we once had contact with the virus but it's gone. (I am immunised for HepB and a marker shows that tells the doctor I have been immunised maybe HepC will just look like that now, seems logical)

Anyway That's my Drs explanation as well as I can relay it and it is just what dr J said here earlier
So don't worry it will be fine.
Love from Ariel #love
Gen 1a
Peg/inf/riba 2012(!?!) stopped at Week 43 due to potassium level ext. low plus other issues (relapse at week 4 post tx, VL120,000) many secondary niggles eg. adenomas.
pre sof/led VL 240,000 Fibrosc F0
Day 25 VL <30
Day 32 UND
Week 10 UND
EOT UND ALT 11 AST 17 GGT 19
SVR4 UND ALT 10 AST 16 GGT 13
SVR8 UND ALT <9 AST 16 GGT 15
SVR12 UND ALT 14 AST 19 GGT 12 Bili 5
EOT +18 ALT13 AST 20 GGT 9 Bili 5
EOT +21 ALT 11 AST 15
Cured at SVR12
Dysplasia Adenoma removed Aug '16
SVR24 UND ALT 11 AST16
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Transmitting the virus after SVR12? 1 year 2 weeks ago #20199

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James-Freeman-facebook wrote:
At SVR there is zero chance of causing infection.

Thanks for clearing this up for me Dr Freeman, it's music to my ears! #love :silly:


And thanks everyone for your comforting replies. Sorry for being a worry wart, I've been in a state of extreme anxiety lately at 8 weeks EOT and seem to be getting worked up about things,.. perhaps not thinking clearly? Just wanting to cover all my bases.

Anyway, onwards and upwards!
genotype 1a
viral load 160,000
age 29, F0, treatment naive, il28bcc
unable to function due to chronic fatigue, joint/muscle pain, low immune system, depression, anxiety, skin issues, brain fog (etc) : (
12 weeks daclatasvir/sofosbuvir started 11 march 2016 through pbs

week 4 - alt 12
week 12 - viral load undetected
svr12 - NOT DETECTED!
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