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Voxilaprevir - A new Protease Inhibitor

TOPIC: Voxilaprevir - A new Protease Inhibitor

Voxilaprevir - A new Protease Inhibitor 5 years 6 months ago #22506

  • vitrus
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8 weeks of vox is quite enough, but 12 weeks is significantly better for everyone.

We are going to get lots of data on retreatment this November.
www.digitaljournal.com/pr/3091534

New treatments of 2016-2017 (More hope for GT3 patients!)
congress-ph.ru/common/htdocs/upload/fm/g.../2016/prez/1-3-2.pdf
(Note that the bullets denoting the drugs' mechanisms of action are misplaced in this presentation)
Gen 1b
VL pre treatment 29000 ME/ml
AST 32 ALT 94, F0
Started treatment 13 January 2017
Generic sofosbuvir/velpatasvir (Incepta)
VL 9 days into treatment <300 (undetected)
AST 13.8 ALT 22
Side effects: mild dehydration, not a problem at all if I drink water at night, nothing to worry about
Diet and gastric ph are very important with velpatasvir. One must think what and when to eat to keep gastric pH low. Side effects disappeared 2 weeks after, unless I ate anything < 4hrs before the pill. SVR60.
Last Edit: 5 years 6 months ago by vitrus.
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Voxilaprevir - A new Protease Inhibitor 5 years 6 months ago #22507

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Hi all, I've moved these Voxilaprevir posts from the Beacon Sofosvel release thread to this one.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 6 months ago #22699

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Chinese factories started selling vox API, but it's not clear if it would be easy for a company to make working pills or capsules from it. No data on voxilaprevir solubility and permeability yet.
Gen 1b
VL pre treatment 29000 ME/ml
AST 32 ALT 94, F0
Started treatment 13 January 2017
Generic sofosbuvir/velpatasvir (Incepta)
VL 9 days into treatment <300 (undetected)
AST 13.8 ALT 22
Side effects: mild dehydration, not a problem at all if I drink water at night, nothing to worry about
Diet and gastric ph are very important with velpatasvir. One must think what and when to eat to keep gastric pH low. Side effects disappeared 2 weeks after, unless I ate anything < 4hrs before the pill. SVR60.
Last Edit: 5 years 6 months ago by vitrus.
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 6 months ago #22705

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Awesome! I looked at mesochem and couldn't find it though. Come on Beacon!
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 6 months ago #22706

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Basic data is starting to emerge

www.chemspider.com/Chemical-Structure.44209500.html
YMMV
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 6 months ago #22708

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Masfik, I am ready. Get Beacon onboard. :cheer:
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 6 months ago #22718

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Voxilaprevir works for retreatment of non-ns5a daa treatment relapsers either.
www.oncologynurseadvisor.com/aasld-2016/...ures/article/571437/
One way is retreating with sof/vel/riba@24, another one - sof/vel@12, yet another one - sof/vel/vox@12. Each has different effectiveness in different cohorts.

NS3 RAVs resulting from treatment generally mostly disappear by themselves in about more than 1 year. Ns5b sof-related RAVs - in about less than 1 year.
However, acquired NS5A RAVs persist, requiring retreatment with drugs having considerably different resistance profile/mechanism of action/high bareer to resistance.
Results from 3-year follow-up study.

www.natap.org/2016/AASLD/AASLD_61.htm

All presentations from AASLD 2016 - the long-awaited data on retreatment.
www.natap.org/2016/AASLD/AASLD.htm
Gen 1b
VL pre treatment 29000 ME/ml
AST 32 ALT 94, F0
Started treatment 13 January 2017
Generic sofosbuvir/velpatasvir (Incepta)
VL 9 days into treatment <300 (undetected)
AST 13.8 ALT 22
Side effects: mild dehydration, not a problem at all if I drink water at night, nothing to worry about
Diet and gastric ph are very important with velpatasvir. One must think what and when to eat to keep gastric pH low. Side effects disappeared 2 weeks after, unless I ate anything < 4hrs before the pill. SVR60.
Last Edit: 5 years 6 months ago by vitrus.
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 5 months ago #22921

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GENO 2B
TREATED WITH iNTERFERON/RIBA IN 1995 Failed
Treated With Soif/Riba 2015/16 Failed
I have followed all trials on Sof/Vel/Vox and it seems to be my best option out there.
Not sure where to source the meds especially the Vox.
Am going to speak to GP2U tomorrow.
dw
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 5 months ago #22927

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I inquired with masfik about Vox and he sent me a response that said, "We are working on it." :cheer:
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 5 months ago #22928

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Awesome news Splitdog! Beacon it seems doesn't let any grass grow beneath their feet. Good for them!
Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!
Last Edit: 5 years 5 months ago by fitz.
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 5 months ago #23034

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Found data on voxilaprevir pharmacokinetics!
regist2.virology-education.com/2016/17HIVHEPPK/40_Kirby.pdf
Reference AUC and Cmax profiles!
TODO: share with all researchers, the data was hard-to-find. (To be done by someone).
Gen 1b
VL pre treatment 29000 ME/ml
AST 32 ALT 94, F0
Started treatment 13 January 2017
Generic sofosbuvir/velpatasvir (Incepta)
VL 9 days into treatment <300 (undetected)
AST 13.8 ALT 22
Side effects: mild dehydration, not a problem at all if I drink water at night, nothing to worry about
Diet and gastric ph are very important with velpatasvir. One must think what and when to eat to keep gastric pH low. Side effects disappeared 2 weeks after, unless I ate anything < 4hrs before the pill. SVR60.
Last Edit: 5 years 5 months ago by vitrus.
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 5 months ago #23042

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Gilead filed for FDA approval. The approval is expected in several months.
The market is about 18 million people.
www.gilead.com/news/press-releases/2016/...patasvirvoxilaprevir
P.S. Likely to be approved either in July or October, 2017 depending on designation.
Gen 1b
VL pre treatment 29000 ME/ml
AST 32 ALT 94, F0
Started treatment 13 January 2017
Generic sofosbuvir/velpatasvir (Incepta)
VL 9 days into treatment <300 (undetected)
AST 13.8 ALT 22
Side effects: mild dehydration, not a problem at all if I drink water at night, nothing to worry about
Diet and gastric ph are very important with velpatasvir. One must think what and when to eat to keep gastric pH low. Side effects disappeared 2 weeks after, unless I ate anything < 4hrs before the pill. SVR60.
Last Edit: 5 years 5 months ago by vitrus.
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 4 months ago #23399

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Come on, Voxy!!! :cheer:
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 2 months ago #23793

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A Voxilaprevir intermediate is now available in China. :cheer:
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 2 months ago #23794

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Haha, so actually available in China even before Gilead goes to market...Awesome :cheer: :+1:

I bet that's because Gilead is sourcing the API's from China.
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
Last Edit: 5 years 2 months ago by Greedfighter.
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