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TOPIC: Treatment intensification for retreatment - add Sofosbuvir

Treatment intensification for retreatment - add Sofosbuvir 2 years 2 weeks ago #25072

  • DrJames
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Here is some data about adding sofosbuvir to salvage patients who failed either Zepatier, or Viekira.

www.aidsmap.com/Treatment-intensificatio...atment/page/3014995/
YMMV
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Treatment intensification for retreatment - add Sofosbuvir 2 years 2 weeks ago #25073

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I think I heard that Zepatier and Sof works great for type 3's. If I'm not mistaken, they achieved 100% of failed prior responder type 3's.
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
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Treatment intensification for retreatment - add Sofosbuvir 2 years 2 weeks ago #25077

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Hi Splitdog,

Here is the EC50 in GT3 for all the drugs. ABT-493/ABT-530 are Maviret (G/P) and GS-9857 is Voxilaprevir.


YMMV
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Treatment intensification for retreatment - add Sofosbuvir 2 years 2 weeks ago #25079

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What is the "pM" and "nM"?
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
Last Edit: 2 years 2 weeks ago by splitdog.
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Treatment intensification for retreatment - add Sofosbuvir 2 years 2 weeks ago #25081

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Hi Splitdog,

pM (pico Moles) and nM (nano Moles) are units of concentration. The smaller the number the stronger the drug, because you only need a sniff of it to work.
YMMV
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