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HCV Viral Load and Speed of Decline Do Not Predict Cure 8 years 1 month ago #12353
Direct-acting antiviral regimens containing sofosbuvir (Sovaldi) and the drugs in Viekira Pak were highly effective regardless of how soon HCV viral load became undetectable after starting treatment, according to research presented at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI). Furthermore, even having low-level detectable HCV RNA at the end of treatment does not preclude a cure, the investigators for a related study concluded. www.hivandhepatitis.com/hcv-basic-scienc...erferon-free-therapy YMMV The following user(s) said Thank You: LondonGirl, Ariel, Gaj, Tina-Hill-facebook, isaing4, Hazel, dacngvn, cowboyjavajoe | |
HCV Viral Load and Speed of Decline Do Not Predict Cure 8 years 1 month ago #12355
| Hello Dr F, I have read much patient experience regarding this, have a friend on VPak detectable EOT and told he'd failed only to go on to clear at 3 months post tx - Interesting. Is there 'any' sort of pattern appearing? GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC The following user(s) said Thank You: Tina-Hill-facebook, isaing4 |
HCV Viral Load and Speed of Decline Do Not Predict Cure 8 years 1 month ago #12370
| Love this article Yes LG I too wonder whether the current EOT and SVR 4 result for Redemption are mirroring what we read in the conclusion of this study, time will tell. Its reassuring for me to have read this as I am still detected <12 upon the EOT (Abbott Real Time Assay). I am hopeful that I too will follow the trend as suggested by the author. If that is not the case at my EOT + 4week VL then I will retreat using a alternative DAA regime with an extended tx period from my first round. Interesting ride ahead awaits me. SVR 24 The following user(s) said Thank You: LondonGirl, isaing4 |
HCV Viral Load and Speed of Decline Do Not Predict Cure 8 years 1 month ago #12377
yes no panic Treatment naive F 3/4 Genotype 1 a & b V/L 17 MILLION Started Harvoni 11th Dec 2015 for 12 weeks 4 weeks VL UND 6 WEEKS ALT 32, AST 34 EOT 03/03 2016 ! UND ALT 34, AST 26 04.04.2016 SVR 4 26.05.2016 SVR 12 16.08.2016 SVR 24 The following user(s) said Thank You: LondonGirl, Tina-Hill-facebook | |
HCV Viral Load and Speed of Decline Do Not Predict Cure 8 years 1 month ago #12380
Yes if you see the US forums there are many examples of this kind of pattern where detected EOT and at 4 weeks EOT but got SVR 12 Even for the doctors these are new drugs and their experiences are limited. The article is a year old but glad its here just reduces the anxiety and panic. Treatment naive F 3/4 Genotype 1 a & b V/L 17 MILLION Started Harvoni 11th Dec 2015 for 12 weeks 4 weeks VL UND 6 WEEKS ALT 32, AST 34 EOT 03/03 2016 ! UND ALT 34, AST 26 04.04.2016 SVR 4 26.05.2016 SVR 12 16.08.2016 SVR 24 The following user(s) said Thank You: LondonGirl, isaing4 | |
HCV Viral Load and Speed of Decline Do Not Predict Cure 8 years 1 month ago #12495
| GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC The following user(s) said Thank You: Tina-Hill-facebook |
HCV Viral Load and Speed of Decline Do Not Predict Cure 8 years 1 month ago #12499
forums.hepmag.com/ Many many stories like this there Treatment naive F 3/4 Genotype 1 a & b V/L 17 MILLION Started Harvoni 11th Dec 2015 for 12 weeks 4 weeks VL UND 6 WEEKS ALT 32, AST 34 EOT 03/03 2016 ! UND ALT 34, AST 26 04.04.2016 SVR 4 26.05.2016 SVR 12 16.08.2016 SVR 24 The following user(s) said Thank You: Tina-Hill-facebook | |
HCV Viral Load and Speed of Decline Do Not Predict Cure 8 years 1 month ago #12505
| Had a chat with my friend previously mentioned, he said he was Detected 15 at EOT , then a few weeks post EOT VL rose to 50, but at week 12 post tx he was UND. GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC The following user(s) said Thank You: Tina-Hill-facebook |
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