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TOPIC: HCV Viral Load and Speed of Decline Do Not Predict Cure

HCV Viral Load and Speed of Decline Do Not Predict Cure 3 years 2 months ago #12353

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Direct-acting antiviral regimens containing sofosbuvir (Sovaldi) and the drugs in Viekira Pak were highly effective regardless of how soon HCV viral load became undetectable after starting treatment, according to research presented at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI). Furthermore, even having low-level detectable HCV RNA at the end of treatment does not preclude a cure, the investigators for a related study concluded.

www.hivandhepatitis.com/hcv-basic-scienc...erferon-free-therapy
YMMV
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HCV Viral Load and Speed of Decline Do Not Predict Cure 3 years 2 months ago #12355

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Hello Dr F, I have read much patient experience regarding this, have a friend on VPak detectable EOT and told he'd failed only to go on to clear at 3 months post tx - Interesting. Is there 'any' sort of pattern appearing?
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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HCV Viral Load and Speed of Decline Do Not Predict Cure 3 years 2 months ago #12370

Love this article

Yes LG I too wonder whether the current EOT and SVR 4 result for Redemption are mirroring what we read in the conclusion of this study, time will tell.

Its reassuring for me to have read this as I am still detected <12 upon the EOT (Abbott Real Time Assay). I am hopeful that I too will follow the trend as suggested by the author. If that is not the case at my EOT + 4week VL then I will retreat using a alternative DAA regime with an extended tx period from my first round.

Interesting ride ahead awaits me.
SVR 24
Last Edit: 3 years 2 months ago by Tina-Hill-facebook.
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HCV Viral Load and Speed of Decline Do Not Predict Cure 3 years 2 months ago #12377

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yes no panic :)
Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
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HCV Viral Load and Speed of Decline Do Not Predict Cure 3 years 2 months ago #12380

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LondonGirl wrote:
Hello Dr F, I have read much patient experience regarding this, have a friend on VPak detectable EOT and told he'd failed only to go on to clear at 3 months post tx - Interesting. Is there 'any' sort of pattern appearing?
Yes if you see the US forums there are many examples of this kind of pattern where detected EOT and at 4 weeks EOT but got SVR 12

Even for the doctors these are new drugs and their experiences are limited. The article is a year old but glad its here just reduces the anxiety and panic.
Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
Last Edit: 3 years 2 months ago by darbara.
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HCV Viral Load and Speed of Decline Do Not Predict Cure 3 years 2 months ago #12495

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GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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HCV Viral Load and Speed of Decline Do Not Predict Cure 3 years 2 months ago #12499

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forums.hepmag.com/
Many many stories like this there
Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
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HCV Viral Load and Speed of Decline Do Not Predict Cure 3 years 2 months ago #12505

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Had a chat with my friend previously mentioned, he said he was Detected 15 at EOT , then a few weeks post EOT VL rose to 50, but at week 12 post tx he was UND.
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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