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TOPIC: Low blood cell counts?

Low blood cell counts? 1 month 3 weeks ago #25359

  • erica
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Ok this is very different from my first tests before starting tx. Everything that was high a month ago is now in range. So that's awesome. Ferritin was 988 and is now 31, which is CRAZY. But here are the things that WERE in range 4 weeks ago that are now OUT of range.

White blood cell count 3.5 (range 3.8 - 10)
Red blood cell count 3.79 (range 3.8 - 5.1)
Absolute neutrophils 1001 (range 1500 - 7800)

And this is just called "ABNORMAL" in my test result:
HCV RNA Quant <15 iu (detected)
HCV RNA Quant <1.18 log (detected)

In my quick internet search, it looks like it's possible that some DAAs can cause red and white blood cell counts to show as low, but not necessarily mean what they normally mean when low. Don't know if that's true or not. I don't feel bad or anything. It's just a strange test result to me. And the HCV RNA tests show the virus is there, just too low to be detected in a Quant test. So that's good. I prefer exact numbers, but whatever. Compared to 8 million I'm good with that for now. :)

Anyone else get low red and white blood cell counts mid tx? Is this common?
Gt 4ACD
No treatment of any kind until FixHepC. <3
Tx started Monday, Sept 18, 2017!!!
Pre-tx: Ferritin 988, AFP 30.2, AST 109, ALT 148, VL 8864293
4wk: Ferritin 31, AST 23, ALT 17, VL <1.18 Log (detected)
8wk: Ferritin 8, AST 18, ALT 20, VL <1.18 Log (UNDETECTED!!!)
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Low blood cell counts? 1 month 3 weeks ago #25360

Hi Erica,

Those blood results are all fine and barely out of range. You have been having phlebotomy so it would be unusual if your red cell count was not a little low and your white cells are fine.

You are still detected, as in <15 detected at the 4 week mark which is ok, but not as good as <15 undetected.

This HCV result does have some predictive value about SVR. We found (in a study of n=448) that 23% of patients are still detected at 4 weeks, but these form 44% of the failures. The VA found similarly in a study of n=4365 - for them the 22% still detected formed 50% of the failures. Failure rates are low, but in rough terms a circa 97% pre treatment success rate currently looks like about 93% for you. It's worth noting that 75% of patients still detected at End Of Treatment still SVR.

The consideration at this time is if adding an extra 4 weeks treatment is worth it for the insurance value. At best it adds 3% or so versus a basline of over 90% so on a "% cure per $ spent" basis it is a bad investment but some people see the value in it.

Nothing to panic about, just something to consider. For patients with GT1 there are lots of retreatement option. There are less for GT3 and it responds slower (which is why we suggest 16 weeks Sof/Dac for it).

I'm happy to have a chat with you in person about it via video if you'd like.
YMMV
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Low blood cell counts? 1 month 3 weeks ago #25361

  • erica
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Thanks Doc. Yeah, I'll make an appointment. That sounds like a good idea. :)
Gt 4ACD
No treatment of any kind until FixHepC. <3
Tx started Monday, Sept 18, 2017!!!
Pre-tx: Ferritin 988, AFP 30.2, AST 109, ALT 148, VL 8864293
4wk: Ferritin 31, AST 23, ALT 17, VL <1.18 Log (detected)
8wk: Ferritin 8, AST 18, ALT 20, VL <1.18 Log (UNDETECTED!!!)
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Low blood cell counts? 1 month 3 weeks ago #25364

  • Greedfighter
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Great results Erica! You're on track to a cure.

Listen and follow all advice given by Dr. Freeman ;) :+1: Just saying....I think you already know that you are in good hands.
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs, VL UND, AST 27, ALT 20
EOT labs, VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24, VL UND, 10/8/16
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Low blood cell counts? 1 month 3 weeks ago #25365

  • erica
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Thank you, Greedfighter! Yes, I definitely do what the Doc says. I trust him with my life. He's quite amazing.
Gt 4ACD
No treatment of any kind until FixHepC. <3
Tx started Monday, Sept 18, 2017!!!
Pre-tx: Ferritin 988, AFP 30.2, AST 109, ALT 148, VL 8864293
4wk: Ferritin 31, AST 23, ALT 17, VL <1.18 Log (detected)
8wk: Ferritin 8, AST 18, ALT 20, VL <1.18 Log (UNDETECTED!!!)
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The following user(s) said Thank You: James-Freeman-facebook, coral, Gaj

Low blood cell counts? 1 week 10 hours ago #25531

Am aceiași problema și eu .La mine in prima săptămâna analizele de sânge a fost ok alt si ast a scăzut numai la 4 săptămâni celule roși mărite,celulele albe scazute(neutrofilele) iar trombocitelor 240
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Low blood cell counts? 6 days 13 hours ago #25534

  • Mnem
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Hi Nelu-Covaci-fb, Minunat să citești postarea ta, sper că rezultatele testului de sânge sunt mai bune acum.
G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!
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Low blood cell counts? 6 days 9 hours ago #25536

Care sunt numerele pentru eritrocite și celule albe?
YMMV
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