emo viral load test

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6 years 6 months ago #5588

hello
my name is Jean Marc ,i leave in Thailand.I have hep c genotype 4 (not see much this genotype on forum..) for min 25 years
6 months ago ,I did a viral load and it was 1 700 000,it took about 2 weeks to get the result (I stay on a small island so it take 2 days of transport to send the blood to the lab).
2 months ago ,I travelled to Bangladesh and bought 3 months of twinvir treatment .
after one month of twinvir ,I went directly to a lab in Bangkok (BRIA) and they told me it will take about a week for the result .But only 3 days after i receive the result <15 witch I was happy,but surprised why it was so fast to have the result!?
Today,I want to asked for a new test (to a different place,again on my small island) and they told me it will take between 2 and 3 weeks .
So I worry about all these differents delays to get result for the viral load test
What should be a normal timing for this test
thank you

Last Edit: 6 years 6 months ago by jeanmarc.

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6 years 6 months ago #5590

Hi Jean Marc, it appears most of the virus is killed off in the first week of treatment, the remainder is cleaned out in the continuation of tx over the next few weeks. However just be sure tx is continued for some 3 months or 6 months depending on liver fibrosis and scaring stage.
Don't be too anxious, your results equate with what many are experiencing here, large log drop in first week and often undetectable at 4 weeks bloods. I had log 5 drop from 1.4million to 77 only in first week, this is quite normal for the DAAs.
good luck to you :)
jim


3 years cured, Sof/Dac, thanks Doc Freeman, hepc only a distant memory, go for it ppl
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6 years 6 months ago #5592

Hi Jean Marc and welcome,

Great to hear you have been able to get treatment. That's a great result after 4 weeks. You are well on your way to being undetected and probably are already given that test was a while ago.

I can't say for certain what is going on in regard to the different length of time it is taking to get results. But based on what I know about how VL testing works in Australia, I can make an educated guess.

VL testing in Australia is only done in a small number of pathology labs (think it's a somewhat complicated test and maybe requires someone with specific training to do it). I live in Tasmania and, as far as I know, no labs here do the test. I believe Royal Hobart Hospital send their VL blood tests to a lab in Melbourne on the Australian mainland and I think I read that the pathology lab Doc Freeman uses send theirs to Brisbane, also on the mainland. And I think in both cases the samples are only sent off one or two days a week. Because of this my results usually take from 10 - 14 days to come back. For people living on the mainland, especially in a city that has a lab that does the test themselves and doesn't have to send it away, it can probably be quicker.

It sounds like the same thing may be going on in Thailand. The first test was quick because you went to Bangkok. Maybe you also had the blood drawn on just the right day when they were running through a batch of samples soon after so it came back even quicker than expected. My guess is that on your island they have to send the samples to the Thai mainland (either Bangkok or some other large metropolitan centre) so the results take longer to come back. In other words, the time it takes to get results can depend on what lab you use, whether they do the test themselves or send the sample away, and how often the lab that can do the actual VL tests does them.

This is just speculation but it seems to fit with what I know about VL testing times in Australia. Hope this helps.


Huon Valley, Tasmania
Hep C+ since 1980s
Genotype 1b
F3/4
VL 480,000
Started Indian Sof and Riba, BMS Dac (comp access) 28 August 2015
UND at 4 weeks
Finished treatment 19 November 2015
12 February 2016 UND SVR12
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6 years 6 months ago #5594

thank you to all the people answering so quick to help !
I can,now, wait for my next result without too much paranoid :)
I hope i'll post the good new in a couple of weeks

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6 years 6 months ago #5608

Hi Jeanmarc, and welcome to the forum.

My viral load tests are done at a major testing lab in London (The Doctors Lab). If I have my blood drawn on a Tuesday at my clinic in Manchester, they have the result on Friday the same week. So, three days is a perfectly reasonable timescale for this test. The longer times that get quoted are to do with this particular test only being done one or two times a week in many labs, and the logistics with the physical blood sample, and maybe posting the results rather than emailing them.

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6 years 6 months ago #5665

Hello Jean Marc

At four week into treatment I had my viral load done and the nurse said results can take at least a week. I live in Sydney and had blood taken at a major hospital. She said viral load takes longer as its a more complicated test. It sounds like your cleared. Good luck to you.


GT2B Diagnosed 1989
Started Tx 6.Nov.2015
F3 Fibroscan 17: April.2015
Alt PreTx: 186 Ast PreTx: 157 VL PreTx: 733,000 27.10.2015
Alt Week 4: 14 Ast Week 4: 28 VL Week 4: UND 7.12.2015
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6 years 6 months ago #5765

jeanmarc wrote:

hello
my name is Jean Marc ,i leave in Thailand.I have hep c genotype 4 (not see much this genotype on forum..) for min 25 years
6 months ago ,I did a viral load and it was 1 700 000,it took about 2 weeks to get the result (I stay on a small island so it take 2 days of transport to send the blood to the lab).
2 months ago ,I travelled to Bangladesh and bought 3 months of twinvir treatment .
after one month of twinvir ,I went directly to a lab in Bangkok (BRIA) and they told me it will take about a week for the result .But only 3 days after i receive the result <15 witch I was happy,but surprised why it was so fast to have the result!?
Today,I want to asked for a new test (to a different place,again on my small island) and they told me it will take between 2 and 3 weeks .
So I worry about all these differents delays to get result for the viral load test
What should be a normal timing for this test
thank you

Hello Jean Marc,

There is another reason why the result time can be different each time. This is because there are several different tipes of RNA tests even among quantitative.

Look at this link (yes, in Russian, but "RNA" and "quantitative" in English.) for price list for commercial pathology clinic. You will see three different quantitative tests and then genotype and qualitative packages of tests.

www.invitro.ru/search/?q=HCV-RNA

The prices for three different quantitative tests alone are 2850, 9800,and 17 600 rubles (AU$55, $AU193, $AU346).
Qualitative 692 rubles $AU14.
Genotype 1045 rubles ($AU21)
Quantitative plus genotype 3500 rubles ($AU69).

These tests are of different kinds and accuracy, which is why the difference in prices. Probably the time takes is different too. I dont know if the tests are faster for more accuracy or what I am just reporting the differences.

So these are the facts.

Maybe an interesting question is how much did you pay for the tests. Were the quicker ones more expensive? Of course in your case is the question of distance to actual test place as well..

But good luck to you in getting a treatment.

(Found you can do translate on this page if it helps here )


G4, F4, cirrhosis.

Thank you to Gilead, Michael Sofia, and the terrific folk at FixHepC for making this adventure possible.

YEAR..... ALT..... AST..... GGT... FERRITIN........................................
2009....... 210..... 215..... 953..... 1400........... (Bad health, stupidity)
2015....... 60....... 45....... 150..... 360............. (Improved diet and health, FixHepC treatment)
2016....... 20....... 24....... 25....... 156............. (SVR 12)
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6 years 5 months ago #6330

so ,this morning ,I received my result and it says < 12 . I suppose it is about the same result as 3 weeks ago (<15) but with a different test method (i suppose).A bit disappointed not having the no detected :(
Now ,I worry .I still have a month of treatment but what I will do if when I finish the treatment I'm still detected with again a <12 result ?Another problem could be that If I have to continue for some more time ,I will have an interruption of the treatment because I will have to order or to travel (both ways taking some time ) to get more twinvir tablets
any advise to anticipate ?
thank you

Last Edit: 6 years 5 months ago by jeanmarc.

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6 years 5 months ago #6349

Ask Doc James, It may mean negativ or UND

The dynamic range of the assay may extends from 12 to 100,000,000 IU/ml, So < 12 means UND

The result < 12 should be followed with a Detected or Undetected


Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
Last Edit: 6 years 5 months ago by Enkel.

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6 years 5 months ago #6362

my lab result after 5 weeks of twinvir


and after 8 weeks of twinvir

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Last Edit: 6 years 5 months ago by jeanmarc.

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6 years 5 months ago #6363

Please post the data part of your result.

The < 12 means we can't count it.

This would usually be followed by Undetected or Detected - it can be too low to count, but still detectable, or too low to count because it is undetectable.


YMMV

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6 years 5 months ago #6364

hello ,i just post at the same time
thank you

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6 years 5 months ago #6365

This assay has a result range of 15 to 100,000,000 IU/mL (1.18 log to 8.00 log IU/mL) for quantification of hepatitis C virus (HCV) RNA in serum.

An "Undetected" result indicates that the HCV is absent in the patient’s serum specimen.

A result of "<15 IU/mL (<1.18 log IU/mL)" indicates that HCV RNA is detected, but the HCV RNA level present cannot be quantified accurately below this lower limit of quantification of this assay. When clinically indicated, follow-up testing with this assay is recommended in 1 to 2 months. To assess response-guided therapy eligibility, an "Undetected" result is required, and a result of "<15 IU/mL mL (<1.18 log IU/mL)" should not be considered equivalent to an "Undetected" result.

A quantitative result expressed in IU/mL and log IU/mL indicates the degree of active HCV viral replication in the patient. Monitoring HCV RNA levels over time is important to assess disease progression and/or monitoring a patient's response to anti-HCV therapy.

A result of ">100,000,000 IU/mL (>8.00 log IU/mL)" indicates the presence of active HCV viral replication, and the HCV RNA level present cannot be quantified accurately above this upper limit of quantification of this assay.

Here is more than you could ever want to know: jcm.asm.org/content/51/2/571.full

The second test is using a different assay (not specified) and once again does not make note of Detected/Undetected status.


YMMV
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6 years 5 months ago #6368

Hi Jeanmarc,

I think your Lab have saved some money by doing only the quantitative. Ask them to clarify you


Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured

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6 years 5 months ago #6396

I had a chuckle at the " Sex :- " bit. I guess you're male.
Sorry. :)


M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
SVR4 at 7Apr16 ALT 22 AST 22
SVR12 at 9Jun16 ALT 23 AST 25
Melbourne, Australia

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