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TOPIC: Australian PBS listing in March!

Australian PBS listing in March! 4 years 4 weeks ago #5634

DrJames Offline Platinum Member Posts: 1901 Thank you received: 6998 Karma: 108	The Turnbull government will spend more than $1 billion to make breakthrough hepatitis C cures available to all as part of an ambitious new plan to eradicate the deadly disease within a generation. www.smh.com.au/federal-politics/politica...20151219-glrib0.html
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Australian PBS listing in March! 4 years 4 weeks ago #5636

Joy Offline Elite Member Posts: 218 Thank you received: 265 Karma: 0	WOW O WOW O WOW ABSOLUTELY FABULOUS NEWS!
	NSW Australia. Genotype 1b 30+ years, F0-F1, VL 91,000 Feb 2015 (740,000 in 2010), Tx naive. Ordered Sof/Dac from Buyers Club 21 Sept, received 14 Oct. Virus UNDETECTED at 3 weeks AND 12 weeks (EOT) AND SVR4 AND SVR12 AND SVR24. A thousand thankyous to Dr James and the amazing FixHepC team. The administrator has disabled public write access.

Australian PBS listing in March! 4 years 4 weeks ago #5638

Jaz Offline Premium Member Posts: 83 Thank you received: 82 Karma: 0	Wow!!
	3a F0 TX Naive Started Tx 12/12/2015 Kingswood Sof/Dac Pre Tx - ALT 71 AST 40 V/L 9 million Day 11 - ALT 12 AST 15 4 week - LFTs normal - detected (same sample sent for v/l showed undetected) :/ 6 week - UND 12 week EOT - UND SVR4 SVR12 The administrator has disabled public write access.

Australian PBS listing in March! 4 years 4 weeks ago #5639

poodle Offline Premium Member Posts: 109 Thank you received: 188 Karma: 2	Its happening how many people will they treat year by year ?
	Geno1a 35years fibrosis 2 or 3 different results from different hospitals ?? 24weeks mesochem sof/led as unsure of fibrosis status. currently UND. No bad side effects Have svr12 ... waiting for svr 24 I now have SVR 36 weeks. The administrator has disabled public write access.

Australian PBS listing in March! 4 years 4 weeks ago #5640

Joy Offline Elite Member Posts: 218 Thank you received: 265 Karma: 0	Hmmm - only a billion $? That means less than $5000 per patient. Does that mean they didn't deal with Gilead??? "The move will make Australia one of the first countries in the world to publicly subsidise the drugs for their entire population, no matter what a patient's condition is or how they contracted the disease." BRAVO!
	NSW Australia. Genotype 1b 30+ years, F0-F1, VL 91,000 Feb 2015 (740,000 in 2010), Tx naive. Ordered Sof/Dac from Buyers Club 21 Sept, received 14 Oct. Virus UNDETECTED at 3 weeks AND 12 weeks (EOT) AND SVR4 AND SVR12 AND SVR24. A thousand thankyous to Dr James and the amazing FixHepC team. The administrator has disabled public write access.

Australian PBS listing in March! 4 years 4 weeks ago #5641

Jaz Offline Premium Member Posts: 83 Thank you received: 82 Karma: 0	So many questions! Or does it mean they will only treat 11,111 people initially? Is this going to be over a long time? 1,000,000,000 / $90,000 = 11,111 ?
	3a F0 TX Naive Started Tx 12/12/2015 Kingswood Sof/Dac Pre Tx - ALT 71 AST 40 V/L 9 million Day 11 - ALT 12 AST 15 4 week - LFTs normal - detected (same sample sent for v/l showed undetected) :/ 6 week - UND 12 week EOT - UND SVR4 SVR12 Last Edit: 4 years 4 weeks ago by Jaz. The administrator has disabled public write access.

Australian PBS listing in March! 4 years 4 weeks ago #5642

sonix
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That's marvellous news! And no mention of triaging patients. I was sure they would limit availability or stall some more. Still, I have no regrets on starting now.

No mention of Viekira Pak which is TGA approved and PBAC recommended. Said to held up because of pricing negotiations but I wonder if safety is also a concern as it is reportedly potentially lethal for patients with significant liver damage.
http://www.fda.gov/Drugs/DrugSafety/ucm468634.htm

M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
SVR4 at 7Apr16 ALT 22 AST 22
SVR12 at 9Jun16 ALT 23 AST 25
Melbourne, Australia

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Australian PBS listing in March! 4 years 4 weeks ago #5643

mgalbrai Offline Moderator Posts: 1327 Thank you received: 2694 Karma: 26	In the U.S., insurers reportedly pay $56,000 for a 12 week tx of Harvoni. Maybe the government of Oz ragged them down even lower. Do you have FOIs down there? Might be interesting to see what price they got. Mike
	This email address is being protected from spambots. You need JavaScript enabled to view it. forums.delphiforums.com/generichcvtx G 1a F-1 Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil 11/17/15 4 wk lab ALT 17 AST 16 <15 11/18/15 Started Harvoni 12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND 1/14/16 Fin. Tx 7/07/16 UND SVR 24 The administrator has disabled public write access.

Australian PBS listing in March! 4 years 4 weeks ago #5644

Enkel Offline Platinum Member Posts: 329 Thank you received: 165 Karma: 0	Maybe a deal with Gilead to take Sovaldi/Harvoni at lower prices like in Egypt. Or maybe generics?
	Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety. Started Twinvir 12/12/15. Two weeks ALT 17 at 2 weeks Viral Load UND at 2 weeks ALT 13.5 at 7 weeks EOT ALT 10.5 at 15 weeks EOT ALT 13 at 27 weeks EOT, VL UND, Cured The administrator has disabled public write access.

Australian PBS listing in March! 4 years 4 weeks ago #5645

sonix Offline Elite Member Music is life Posts: 165 Thank you received: 359 Karma: 2	Just noticed the time on the SMH article, 10 minutes from now. Great prescience Dr James!
	M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15. SVR4 at 7Apr16 ALT 22 AST 22 SVR12 at 9Jun16 ALT 23 AST 25 Melbourne, Australia The administrator has disabled public write access.

Australian PBS listing in March! 4 years 4 weeks ago #5646

poodle Offline Premium Member Posts: 109 Thank you received: 188 Karma: 2	In the SMH it did quote Malcolm as saying "within a generation" to eradicate from the population. .. is that another way saying its going to take a while to treat everyone?
	Geno1a 35years fibrosis 2 or 3 different results from different hospitals ?? 24weeks mesochem sof/led as unsure of fibrosis status. currently UND. No bad side effects Have svr12 ... waiting for svr 24 I now have SVR 36 weeks. The administrator has disabled public write access.

Australian PBS listing in March! 4 years 4 weeks ago #5652

Nonna
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The cost of the medication was to decrease the more people treated. Gilead were assured of there profit and when they got it the price is reduced. So the price is on a downward scale not fixed per course of treatment. This is what I was told when they were negotiating earlier.

Just awesome news. All those gastros calling patients back in March April for treatment seem to have had a pretty good idea of the upcoming approval.

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Australian PBS listing in March! 4 years 4 weeks ago #5653

Vororo
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James-Freeman-facebook wrote:

The Turnbull government will spend more than $1 billion to make breakthrough hepatitis C cures available to all as part of an ambitious new plan to eradicate the deadly disease within a generation.

www.smh.com.au/federal-politics/politica...20151219-glrib0.html

This is great news for Australians... And crucially, the article states:

"The move will make Australia one of the first countries in the world to publicly subsidise the drugs for their entire population, no matter what a patient's condition is or how they contracted the disease."

A quick calculation - let's suppose the govt will pay Gilead 50 000 per patient: 230 000 * 50 000 = 11 500 000 000 (11.5 BIllion). Therefore, assuming a spend of 1 Billion per year, it will take 11.5 years.

Of course, not all of this money goes to Gilead, so add a few more years. And of course prices will come down so subtract a few years (and/or dollars).

Conclusion?

1. The Australian Govt will finally cover everyone who is really sick. Great News!!

2. Its reasonable to suppose there will be prioritisation of patients in the first few years, which is completely fair, given the cost.

3. For everyone else who wants treatment now, they will still need to look to generics, e.g. with fixHepC

But Wait A Minute!

Who wants to bet on whether the Australian Government will source from Gilead or from the generics?

If its from Gilead, guess what kind of "voluntary" anti-generic deal Gilead will try to slip in ???

Oh, shit... Now is the time for everyone in Australia to do some very heavy lobbying !!! .

We live in dangerous times.

Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
Week4: AST 47, ALT 58. VL < 15 (unquantifiable).
Week12 (EOT): AST 30, ALT 26, VL UND
Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND
Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND
Ever grateful to Dr James.

Relapsed somewhere after all that... Bummer!

Jan 2018: VL 63 000 (still GT3).

Last Edit: 4 years 4 weeks ago by Vororo.

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Australian PBS listing in March! 4 years 4 weeks ago #5654

mgalbrai
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Until everyone who is sick and wants to be treated sooner rather than later, can access treatment, the Buyer's Club is THE place. A billion dollars is a start and a great thing.
It is still just a start.
M

This email address is being protected from spambots. You need JavaScript enabled to view it.
forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24

Last Edit: 4 years 4 weeks ago by mgalbrai. Reason: Addition

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Australian PBS listing in March! 4 years 4 weeks ago #5657

Felix Offline New Member Posts: 5 Thank you received: 13 Karma: 1	Congratulations, James. This is fantastic news. Unlikely that this would have happened without you.
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