Welcome, Guest
Username: Password: Remember me

TOPIC: Swollen Mouth Allergic Reaction? Sovaldi/ Daclinza Combo?

Swollen Mouth Allergic Reaction? Sovaldi/ Daclinza Combo? 2 years 1 month ago #19115

  • Happylady
  • Happylady's Avatar
  • Offline
  • New Member
  • G2B since 2005. never Had Treatment. 23/09/2014 Viral Load 3mil
  • Posts: 3
  • Thank you received: 3
  • Karma: 0
Hi Everyone. I started treatment of Sovaldi and Daclinza 3 days ago. After my second dose of meds my teeth began to really hurt and I realised that my mouth and gums are really swollen. They are puffy. Has anyone else had this problem? The pain is pretty bad and feels like I have a really bad cavity except I dont have any cavities. My cheeks are quite swollen. Looks like I have been punched in face except there are no bruises. I have stopped taking the meds today as im scared its an allergic reaction?. Should I reduce the dose? I read the Sovaldi insert and it says that swollen gums can be a side effect of this medication. No other side effects except for sore muscles. I was so excited to start treatment now not sure how to proceed? Any similar experiences appreciated. Sorry for not putting my iALP AST info on profile Ive tried and cant figure out how to add to profile. Thanks Happy lady
The administrator has disabled public write access.
The following user(s) said Thank You: Hazel

Swollen Mouth Allergic Reaction? Sovaldi/ Daclinza Combo? 2 years 1 month ago #19116

  • pat1
  • pat1's Avatar
  • Offline
  • Platinum Member
  • Posts: 340
  • Thank you received: 978
  • Karma: 15
Hi Happy Lady
I'm sorry to read that you are experiencing a possible reaction since taking Solvaldi and Daclinza. Do you have a doctor monitoring you while on treatment? Did you buy your meds through Redemption? I suggest that before changing your dose you would require the appropriate medical advice. I hope someone comes along to help you very soon. #flower
To add info to your signature go to the Profile tab and use the edit function to add more details. This information will assist others on the forum to help with your post.
gt 1a VL 6m
F2/3 FibroScan - 9KPa in 2011 and 7KPa in 2015
sof/dac 10 December for 12 weeks
pre tx alt 85 ast 51
4 wk alt 34 ast 31 UND <35
8 wk alt 29 ast 32 UND <15
12wk alt 25 ast 25 EOT 3.3.16
SVR24 UND KPa5.3 F0 in normal range
I am well
.forever grateful to fixhepc
Last Edit: 2 years 1 month ago by pat1.
The administrator has disabled public write access.
The following user(s) said Thank You: LondonGirl, Gaj, Hazel

Swollen Mouth Allergic Reaction? Sovaldi/ Daclinza Combo? 2 years 1 month ago #19117

  • LondonGirl
  • LondonGirl's Avatar
  • Offline
  • Platinum Member
  • Posts: 1366
  • Thank you received: 2130
  • Karma: 17
Hi Happy Lady,

Really hope you get some professional advise soon. Yes, it would be extremely helpful if you could fill out your profile section.

Meanwhile, Suggest you make sure you're drinking enough good quality water.

LG
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
The administrator has disabled public write access.
The following user(s) said Thank You: pat1

Swollen Mouth Allergic Reaction? Sovaldi/ Daclinza Combo? 2 years 1 month ago #19119

  • klhilde
  • klhilde's Avatar
  • Offline
  • Elite Member
  • Posts: 253
  • Thank you received: 503
  • Karma: 6
I'm not sure where you sourced your treatment, but if it's from MonkMed, I'd get on the phone with Tim and arrange a talk with one of their doctors. If not, and you can't see your local specialist or GP, then I'd get an online appointment with Dr. Freeman at GP2U.

All that said, ........... be clear that I am NOT a doctor, and you should treat everything I'm about to say as speculation ........
I've come to the suspicion that Hep C creates an environment which leaves people susceptible to bacterial overgrowth ... usually Candida Albicans. I suspect some of the symptoms associated with the Hep are really Candida symptoms. It would explain things like the gastric issues we see on treatment, among many others. If you have a Candida overgrowth it can also be in your mouth. You might want to talk to the doctor about that. In any case, a quick treatment with Nystatin will wipe out most of it, but you would need to use some as a rinse for your mouth. Nystatin is not absorbed into the body so can only reach what's in your intestinal tract. For anything more advanced you would need an absorbable drug, typically fluconazole (which is hard on the liver.)

Maybe Dr. Freeman will pop in here and give you some advise.
Last Edit: 2 years 1 month ago by klhilde.
The administrator has disabled public write access.
The following user(s) said Thank You: pat1, MonkMed

Swollen Mouth Allergic Reaction? Sovaldi/ Daclinza Combo? 2 years 1 month ago #19121

  • GT2
  • GT2's Avatar
  • Offline
  • Elite Member
  • Posts: 295
  • Thank you received: 969
  • Karma: 9
Hi Happylady

I’m sorry to hear about your side effects to Sovaldi + Daclinza.

I was diagnosed with genotype 2 and just finished taking 12 weeks of generic Sofosbuvir + generic Daclatasvir.

After about 4 weeks, I started getting pain in my back molars (like I had cavities), and they became sensitive to cold. One of them would throb at night and would wake me up. I read somewhere that we all should have dental check-ups before DAA treatment. For me, however, that was too late. So, I started brushing my teeth after every meal with a soft brush and then rinsed with Listerine Total Care. After about a week or so the pain went away. I continued brushing my teeth 3 times a day (became a habit) and, for the last month, only rinsing with Listerine at night & had no further problems.

I also read that you have been diagnosed with a pituitary tumour. If you are having concurrent treatment, your side effects may be magnified by the SOF + DCV reacting with the other medication that you are taking.

This is how to add a signature to your profile:

Scroll to the top of any forum screen, click on the 'Profile' tab.

- Then click the 'edit' button on the right of the grey bar at the top of your profile.

- Enter your password in the required field, repeat to confirm, then click the 'Save' button.

- Click on the profile information tab and scroll down to signature panel and add what you want. There are also other fields in the profile page that you can edit if you want.

- Click on 'Save' when finished. That will take you back to your user account page. Click 'Save' again.

I hope that this helps.

Cheers
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected :cheer: :) , FBG 11.9 :huh:
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
:) (Accu-Chek Mobile & Omron Auto BP Monitor) :)
The administrator has disabled public write access.
The following user(s) said Thank You: pat1

Swollen Mouth Allergic Reaction? Sovaldi/ Daclinza Combo? 2 years 1 month ago #19122

  • pat1
  • pat1's Avatar
  • Offline
  • Platinum Member
  • Posts: 340
  • Thank you received: 978
  • Karma: 15
I sent a PM to you Happylady
I am not a medico either #flower
gt 1a VL 6m
F2/3 FibroScan - 9KPa in 2011 and 7KPa in 2015
sof/dac 10 December for 12 weeks
pre tx alt 85 ast 51
4 wk alt 34 ast 31 UND <35
8 wk alt 29 ast 32 UND <15
12wk alt 25 ast 25 EOT 3.3.16
SVR24 UND KPa5.3 F0 in normal range
I am well
.forever grateful to fixhepc
Last Edit: 2 years 1 month ago by pat1.
The administrator has disabled public write access.

Swollen Mouth Allergic Reaction? Sovaldi/ Daclinza Combo? 2 years 1 month ago #19125

  • Gaj
  • Gaj's Avatar
  • Offline
  • Moderator
  • Optimist :-)
  • Posts: 1436
  • Thank you received: 3084
  • Karma: 31
Welcome Happylady,

Not a doctor either but I would suggest seeing or talking with one as you say there is noticeable swelling of your mouth or gums and the insert recommends that course in case it is an allergy. Don't try a reduced dose without expert advice. It may also be a candida infection and if so the doctor will tell you straight away and recommend something for it allowing you to restart treatment. :)
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 2 years 1 month ago by Gaj.
The administrator has disabled public write access.
The following user(s) said Thank You: pat1

Swollen Mouth Allergic Reaction? Sovaldi/ Daclinza Combo? 2 years 1 month ago #19128

  • LondonGirl
  • LondonGirl's Avatar
  • Offline
  • Platinum Member
  • Posts: 1366
  • Thank you received: 2130
  • Karma: 17
but if it's from MonkMed, I'd get on the phone with Tim and arrange a talk with one of their doctors.

I believe, you can still contact MonkMed and pay a very affordable fee for a consultation with a Dr whether you are a patient already or not. MonkMed have been telemed Drs for travelers for some time prior to teaming up with Dr F and FixHepC . You can contact This email address is being protected from spambots. You need JavaScript enabled to view it. and ask if you can get an appointment. Dr Debasis is excellent if Dr Freeman isn't around or you can't see your consultant. Missing doses can't be good and recommend you seek advise if you haven't already.
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
The administrator has disabled public write access.
The following user(s) said Thank You: pat1, Gaj, MonkMed

Swollen Mouth Allergic Reaction? Sovaldi/ Daclinza Combo? 2 years 1 month ago #19148

  • Sven
  • Sven's Avatar
  • Offline
  • Elite Member
  • Posts: 293
  • Thank you received: 1065
  • Karma: 18
Where did you procure the meds? I would connect with them right away, they'll be able to steer you in the right direction. I hope it is a great source like GP2U.
Post a message back so we know how to move forward.
Contracted HCV 1980's
Geno Type 1a
F3 ( doc says once treated I'll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count - 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!
The administrator has disabled public write access.

Swollen Mouth Allergic Reaction? Sovaldi/ Daclinza Combo? 2 years 1 month ago #19149

  • fretboard
  • fretboard's Avatar
  • Offline
  • Elite Member
  • Defender-Against Big Pharma!
  • Posts: 175
  • Thank you received: 340
  • Karma: 3
Hey Happylady,
You did right by stopping the meds. My guess is its an allergic reaction to the Dac. Please, see a doctor soon so you can get a proper consult. good luck

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

www.webmd.com/drugs/2/drug-169307/daklin...details#side-effects
G1a dx'd in 1992, Biopsy F2 VL 8mill +. Tried tx with Interferon/Riba, back in 2008 didn't last long it felt horribly ugly!! I stopped tx, after 5 weeks!!
Started tx 6/1/16 with Harvoni.
12 Month Labs= UND
The administrator has disabled public write access.
The following user(s) said Thank You: LondonGirl, fitz

Swollen Mouth Allergic Reaction? Sovaldi/ Daclinza Combo? 2 years 1 month ago #19179

  • DrJames
  • DrJames's Avatar
  • Offline
  • Platinum Member
  • Posts: 1628
  • Thank you received: 6135
  • Karma: 95
Hello Happylady,

Yes it could be an drug reaction. If so stopping the drugs should see it go away and stopping them immediately was sensible.

If it does not go away then it must be something else and must be looked into. Even if it does go away it's still possible it is, say, something you ate. I have a friend who gets that reaction from strawberries.

Assuming it goes away we get to the interesting part. To restart, or not to restart. Provided you did not get hives, wheezing, swollen tongue/throat or problems with breathing this should be safe enough.

If you restart the meds once things are settled and get the same reaction there is no doubt it's the meds.....

I noticed you used the words Sovaldi and Daklinza so presume it's originator medication, not that that matters. More important would be if that indicates you are GT3.
YMMV
The administrator has disabled public write access.
The following user(s) said Thank You: GT2, fitz
Time to create page: 0.138 seconds

Copyright © 2015-2017 FixHepC

Back to Top