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TOPIC: Mavyret 18th day

Mavyret 18th day 4 days 16 hours ago #27299

  • tototo
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Hello,
Thank you in advance for your help. I am on day 18th of mavyret and very concerned with side effects:
I dont' feel like myself since i started treatment. There was one day after the first week that i felt lots of energy and a very clear mind, which was so nice to feel , but have not experienced another such day.
I have been taking the pills religiously at 2pm but today switched to 6 pm.
I made this change because this is what happens:
I wake up in the morning feeling normal everyday. Around two hours later it starts feeling foggy and just with a cloud over my head. I take medication with food at 2pm and around 5 I feel very tired.
Have been going to bed at 8:30 fall asleep and wake up at midnight, two, or 3am, and can't go back to sleep for a couple of hours..
I have a running nose like I would have a flu and sneeze like I do have it.
I changed the schedule hoping that by the time I start feeling tired is about 9pm, I sleep through it and wake up refreshed.
Let's see how it goes...
Started treatment October 25th
1A
Fibrosis 1 to 2 F
VL 1980000

No other medication being taken

Dr wanted me to take first blood test on November 1st, seven days into treatment but I suspect it is too early, and since he does not want to to run other tests not until I am done with treatment I taking the tests on November 12th.
I just hope that nothing really bed is going on and that I regret not taking the tests 7 days into treatment.

I am so worried.
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Mavyret 18th day 3 days 13 hours ago #27302

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Hello tototo,

Sorry to hear you seem to be having a bit of a hard time with the medication. While it's unusual it does happen. You may find increasing your fluid intake and trying some vitamin B12 help matters.

Usually, we see thing settle down during the course of treatment as the virus is removed.

It does sound like side effects related to the Maviret, so it might be best to take it just before bed, that way you will (hopefully) sleep through them (and the tiredness you get 3 hours after will be hidden during sleep).
YMMV
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Mavyret 18th day 3 days 13 hours ago #27304

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Hi Dr James, Thank you for your advice. I am already taking B12 sublingual, do you think I should take a B12 shot?
I am also taking vitamin A because I am concerned with a side effect related to blurred vision. I read complaints about it which don't subside after treatment. Do you know of patients taking Maviret that had s vision problems?
Can you please advise when it would be the best time to take the first test for viral load?
I am thinking this Monday, 22 days after treatment.
Should I wait for three weeks to be complete in order to take the test?
I am having insomnia can you recommend a relaxer - I asked my Dr but he says I should not take anything to help me sleep.
He says diazepam is processed by the liver therefore I should not take it.

May I ask another question?
I use oregano oil topically. Do you think this oil can jeopardize treatment?

Thank you for your help. And sorry for so many questions.

C

Thank you
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Mavyret 18th day 2 days 17 hours ago #27308

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Doing the test at 28 days shows undetected in most 80% of patients taking Sofosbuvir.

Maviret has a protease inhibitor which gives aslightly faster response so 22 days is fine.

Oral B12 and IM work the same.

Routine sleepers like temazepam and diazepam are 100% fine.

Topical medications are fine.
YMMV
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Mavyret 18th day 18 hours 8 minutes ago #27316

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Thank you Dr James!
Feeling much better, a little light headed, but well.
I did adjust medication and now taking it before bed.
Will do VL and other tests on Nov 16th , 22 days into treatment.

The main issue now is lack of apetite.
Will post test results.
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Mavyret 18th day 13 hours 48 minutes ago #27319

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I'll look forward to seeing your results!
YMMV
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