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TOPIC: HARVONI FATIGUE

HARVONI FATIGUE 3 years 6 months ago #15225

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my muscles are still sore.

Are you taking any other medications?
YMMV
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HARVONI FATIGUE 3 years 6 months ago #15226

James-Freeman-facebook wrote:
my muscles are still sore.

Are you taking any other medications?

Hi Dr James,
Below are the meds that I'm on.
During treatment, I didn't take any Simvastatin or Pantoprazole.

Ezetimibe 10mg mane, Simvastatin 5mg mane, Clopidogrel 75mg/Aspirin 100mg mane, Olmesartan 40mg/Amlodipine 10mg mane, Pantoprazole 20mg
AUSTRALIAN
HCV Genotype 1a
2003 Relapsed Peg Interferon / Ribavirin
Pre treatment VL 2,000,000
ALT 65, AST 42, ALP 111, GGT 56
Bridging F3-4
Treatment -24 weeks - Sof , Led with 12 weeks Riba.
4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14
12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20
24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14
EOT 6th April 2016
SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20
Last Edit: 3 years 6 months ago by Michael-Henry-facebook. Reason: Add a space
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HARVONI FATIGUE 3 years 6 months ago #15270

Hi Michael

If I recall correctly you did a 24 week course of meds? so maybe due to that it may take your body a little longer to get firing on all 6 cylinders again. As for the sore muscles I can tell you that magnesium works small wonders. I used to do a lot of competitive swimming and running - on the days when I had a hard core training session I would take a couple of mag tablets a couple of hours before bed and found the next day that the muscle pain was more bearable.

P.S really like your avatar pic :cheer:
SVR 24
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HARVONI FATIGUE 3 years 6 months ago #15272

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Both ezetimbe and simvastatin can cause myopathy and myalgia (sore muscles). Getting your CK (creatine kinase) enzyme checked via a blood test would be a good idea. If it is elevated consider stopping one.
YMMV
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HARVONI FATIGUE 3 years 6 months ago #15274

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I must be one of the lucky ones. :cheer: I have more energy, brain is sharper and I'm feeling braver. Swimming faster, feeling stronger. Definitely firing on more cylinders. Today is the last day of week 6 so all this might change. Felt a bit tired this week but maybe that's because I didn't have my customary Nana nap on any of the weekend days and was quite busy. 3 Yoga classes a week is helping me for sure and I do supported inversions most days.
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
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HARVONI FATIGUE 3 years 6 months ago #15290

beaches wrote:
I must be one of the lucky ones. :cheer: I have more energy, brain is sharper and I'm feeling braver. Swimming faster, feeling stronger. Definitely firing on more cylinders. Today is the last day of week 6 so all this might change. Felt a bit tired this week but maybe that's because I didn't have my customary Nana nap on any of the weekend days and was quite busy. 3 Yoga classes a week is helping me for sure and I do supported inversions most days.


Great to hear you are rocking it Beaches - I cant believe you are at end of the 6 week mark...seems like only a couple of weeks ago you signed up here and posted that funny Harvoni pic. :woohoo:
SVR 24
Last Edit: 3 years 6 months ago by Tina-Hill-facebook.
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HARVONI FATIGUE 3 years 6 months ago #15308

James-Freeman-facebook wrote:
Both ezetimbe and simvastatin can cause myopathy and myalgia (sore muscles). Getting your CK (creatine kinase) enzyme checked via a blood test would be a good idea. If it is elevated consider stopping one.

Thanks Dr James,
I will get a CK enzyme blood test done & if elevated, I will stop the Ezetimbe .
I was thinking about going off all meds for a month & see how I feel.
But as all these meds I was prescribed after I had my stroke 3 years ago.
AUSTRALIAN
HCV Genotype 1a
2003 Relapsed Peg Interferon / Ribavirin
Pre treatment VL 2,000,000
ALT 65, AST 42, ALP 111, GGT 56
Bridging F3-4
Treatment -24 weeks - Sof , Led with 12 weeks Riba.
4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14
12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20
24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14
EOT 6th April 2016
SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20
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HARVONI FATIGUE 3 years 6 months ago #15311

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But as all these meds I was prescribed after I had my stroke 3 years ago.

The statin at low dose should be continued for it's anti-stroke effects. Keeping you blood pressure under control and using antiplatelet therapy like aspirin also helps.
YMMV
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HARVONI FATIGUE 3 years 6 months ago #15775

James-Freeman-facebook wrote:
Both ezetimbe and simvastatin can cause myopathy and myalgia (sore muscles). Getting your CK (creatine kinase) enzyme checked via a blood test would be a good idea. If it is elevated consider stopping one.

Dr James, below are the blood tests I had yesterday.
The good news is that my muscle aches & pains are getting less.
My wife & I just returned from a 7 day self drive holiday in NZ, where I did lots of walking tracks.
To my surprise my muscles started to ache but I just kept on pushing on & the pain got less.
Maybe being post Tx 4weeks, my liver is starting to recover from having the hepC virus for 45 years.

Monday 9/5/16
Fasting Blood Test
S&N Pathology

Hepatitis C Virus RNA Qualitative

FBC

EUC

LFT

CK

Vitamin D

Anaemia

Vitamin B12

Lipids

Cholesterol (fasting)
AUSTRALIAN
HCV Genotype 1a
2003 Relapsed Peg Interferon / Ribavirin
Pre treatment VL 2,000,000
ALT 65, AST 42, ALP 111, GGT 56
Bridging F3-4
Treatment -24 weeks - Sof , Led with 12 weeks Riba.
4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14
12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20
24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14
EOT 6th April 2016
SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20
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HARVONI FATIGUE 3 years 6 months ago #15776

Tina-Hill-facebook wrote:
Hi Michael

If I recall correctly you did a 24 week course of meds? so maybe due to that it may take your body a little longer to get firing on all 6 cylinders again. As for the sore muscles I can tell you that magnesium works small wonders. I used to do a lot of competitive swimming and running - on the days when I had a hard core training session I would take a couple of mag tablets a couple of hours before bed and found the next day that the muscle pain was more bearable.

P.S really like your avatar pic :cheer:

Sorry for the delayed reply Tina .
5 weeks after treatment & my muscle aches & pains have been getting better.
I'm starting to feel more alive :-)
AUSTRALIAN
HCV Genotype 1a
2003 Relapsed Peg Interferon / Ribavirin
Pre treatment VL 2,000,000
ALT 65, AST 42, ALP 111, GGT 56
Bridging F3-4
Treatment -24 weeks - Sof , Led with 12 weeks Riba.
4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14
12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20
24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14
EOT 6th April 2016
SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20
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HARVONI FATIGUE 3 years 6 months ago #15781

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Great to read that you had a fun road trip in NZ and that you're more limber now too with less pain
I'm happy for you Michael-Henry
Happies from Ariel #flower
Gen 1a
Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas.
pre sof/led VL 240,000 Fibsc F0
Day 25 <30
Day 32 UND
Week 10 UND
EOT UND ALT11AST17GGT19
SVR4 UND ALT10 AST16 GGT13
SVR8 UND ALT <9 AST16 GGT15
SVR12 UND ALT14 AST19 GGT12 Bili 5
EOT +18 ALT13 AST20 GGT9 Bili 5
EOT +21 ALT11AST15
Cured SVR12
Dysplasia Adenomas RemvdAug '16
SVR24 UND ALT11AST16
ColonoscopyClear Nov17
LumpectomyClear ‘18
LithotripsyCytoscopyBiopsy 4/18
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HARVONI FATIGUE 3 years 6 months ago #15789

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Gotta say I am 3 weeks post treatment and feel better all the time. Much more energy, less joint pain.
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs, VL UND, AST 27, ALT 20
EOT labs, VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24, VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
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HARVONI FATIGUE 3 years 2 months ago #21267

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3 weeks into ledipasvir and sofosbuvir ( Hepcinat LP )

I'm experiencing increased
Fatigue
Irritability
Indigestion
Intermittent muscle, oral, and liver pains
coughing due to excess mucus production
headaches
stiff & crackly joints

all are welcome.

This means the medication is working and is killing the virus.

I can put up with it for another 9 ( hopefully ) weeks...

49 years hosting this virus is plenty.
Last Edit: 3 years 2 months ago by claudel.
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HARVONI FATIGUE 3 years 2 months ago #21305

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Hi Claudel I am four weeks after EOT today but can recognize some of those sides while on generic harvoni. One of the things that helped me a lot to keep them at bay was to drink 64 ounces (2 litters) of fluids a day and avoid heavy foods (we usually know what they are! :silly: ). But keeping well hydrated seemed to do the trick for me specially for headaches! Best of luck, it might be that like me and others you also get to experience a sort of " high" from the DAAs and enjoy a great surge of energy for few weeks. It happened to me during weeks 3, 4 and 5! #flower #flower
Blood transfusion in 1992 - Diagnosed in 2007
Tx naive -G1b - F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs - Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 - ALT 10 - GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 - ALT 8 - GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)

SVR 4 Virus UND (September 7th)
AST 13 - ALT 5

SVR 14 Virus UND (November 12th)
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HARVONI FATIGUE 3 years 2 months ago #21306

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Hi Meg

None of the sides are anything more than annoying to me at this point ( 58 more pills to go... )

I'm having way less distress than I did with interferon/ribavarin.

I got an energy boost right when I started taking it that lasted a week or so before I started getting a variety of extra symptoms.

I've been drinking lots of water and avoiding foods I've found to be problematic in the past.

At the moment indigestion is the worst of it for me and I don't want to take anything for it that might interfere with the antivirals.

I can tolerate it, I'm almost 1/3 done.

I'm just going to take it easy until I take all the medicine.

Thanks...
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