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Sofosburvir + Daclatasvir Worried about KRATOM usage 3 years 7 months ago #27913

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Hi Christoffer, welcome to the forum, and congratulations on starting treatment with Epclusa, it's a really great drug :+1: . Regarding the use of Kratom with Epclusa, a previous answer in this thread by Dr James Freeman, FixHepC's founder, states that Kratom should be avoided when treated with Daclatasvir medication, and that "it should be ok, but..." (so maybe best avoided) when treated with Epclusa medication. He also said "I do tell my patients you can’t get problems from drugs you are not taking...". So it's probably wise to avoid it during treatment to eliminate any doubt. It's also worth noting that the patient in this thread also said "I felt so much better after finishing Epclusa I never bothered with kratom again".
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Sofosburvir + Daclatasvir Worried about KRATOM usage 3 years 7 months ago #27914

Christoffer, stop the kratom now. Dr. James mentioned that kratom might increase levels of one of the active ingredients of Epclusa to toxic levels:

It (kratom) is a potent inhibitor of a number of cytochromes including the CYP3A4 one that metabolised daclatasvir so would be expected to cause daclatasvir toxicity or increased side effects.


Better not to use any herbal supplements while taking Epclusa unless approved by your treating physician.
The following user(s) said Thank You: hanknassi, Mar

Sofosburvir + Daclatasvir Worried about KRATOM usage 1 month 3 weeks ago #29803

Cheap Harvoni - onlinecheappills.com/harvoni.html I took harvoni for 3 months, missing only 1 dose which I made up quickly. No side effects at all. Tiredness was equal to tiredness prior to taking. I received my 2 month blood test after treatment & I AM CURED!!
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Sofosburvir + Daclatasvir Worried about KRATOM usage 1 month 3 weeks ago #29804

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Hi valesolove, all the best with your treatment. Yes, the combination of Sofosbuvir + Daclatasvir is very effective. The majority of patients however experience mild side effects, so you're one of the few people who experienced strong side effects unfortunately. Drinking a lot of fluids is a sure way to minimize side effects during treatment, so you may want to try that.
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