Yes this could be a problem for both the Sofosbuvir and the Daclatasvir, both of which would be expected to be at higher levels in your blood stream due to Kratom inhibiting their metabolism. This might be helpful for you as 8 weeks treatment with Sof+Dac for GT1 is borderline - you should take 12 weeks, but is not to be recommended.
www.dovepress.com/pharmacokinetics-of-mi...ulltext-article-DDDT
Kratom has the potential herb–drug interaction on cytochrome P450 (CYP) enzyme activity. This was shown in one study, with potent inhibitory effect for CYP3A4 and CYP2D6, moderate effect for CYP1A2, and weak effect for CYP2C19,22 whereas in another study, mitragynine and 7-hydroxymitragynine also showed the inhibitory effect on P-glycoprotein.23 However, there were a few reports of Kratom-related fatalities.
Daclatasvir is metabolised by CYPD3A4 so if you inhibit it with Kratom you will run high levels of Daclatasvir in your blood.
www.medscape.com/viewarticle/842315
Sofosbuvir, like many drugs, is partially cleared via the p-glycoprotein transporter (P-GP) system.
So Kratom is also expected to elevate your Sofosbuvir levels and it can be cardiotoxic in high doses.
Advice
You should seriously consider not taking Kratom for the duration of treatment.
You should also seriously consider getting another 4 weeks treatment.
