Home Forums Main Forum Experts Corner Drug Interactions & Information Which DAA regimen should include ribavirin?

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  • #1762
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    A patient posted this in another thread. It is a key thing to understand.

    [video]https://www.youtube.com/watch?v=vCcpES8O6P0[/video]


    YMMV

    #1763
    Avatar phototweakmax
    • Guardian Angel
    • ★★★★★
    @tweakmax

    Doc freeman may be right abt sof + dac + sime combo

    Janssen doing a trial on it

    #1767
    miko3
    • Topics: 5
    • Replies: 82
    • Total: 87
    • Guardian Angel
    • ★★★★★
    @miko3

    Dr James.Some suggested regimes call for a 7 day lead in with sof alone,before adding any extra DAA’s.This is not mentioned in the excellent video clip.Do you have an opinion on this or is it irrelevant?


    Gen 1b 40yrs,tx naive, f3/f4.VL too high to quantify.
    Started tx 12Oct.sof and riba India via greg.Dac from Mesochem.
    4wk result virus not detected,all liver functions in normal ranges.
    Only SE intermittent insomnia.Feel great and grateful otherwise

    #1768
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello Miko, yes I have an opinion. I think it’s a bad idea based on the mechanisms of resistance. If you think of killing Hep C as being like killing all the enemy soldiers in an area you don’t start half hearted, you go in with overwhelming force and kill everyone before (selected resistance) provides an opportunity for the enemy to regroup.

    On the more evidence based front patients taking Harvoni (before it even had that name) in the ion-1 trial took the Sof+Led combination from day 1. Why vary from that proven approach?


    YMMV

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