emo Which DAA regimen should include ribavirin?

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6 years 8 months ago #688

A patient posted this in another thread. It is a key thing to understand.


YMMV
Last Edit: 6 years 8 months ago by DrJames.
The following user(s) said Thank You: miko3, WILSON1, padera

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6 years 8 months ago #689

Doc freeman may be right abt sof + dac + sime combo

Janssen doing a trial on it

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6 years 8 months ago #694

Dr James.Some suggested regimes call for a 7 day lead in with sof alone,before adding any extra DAA's.This is not mentioned in the excellent video clip.Do you have an opinion on this or is it irrelevant?


Gen 1b 40yrs,tx naive, f3/f4.VL too high to quantify.
Started tx 12Oct.sof and riba India via greg.Dac from Mesochem.
4wk result virus not detected,all liver functions in normal ranges.
Only SE intermittent insomnia.Feel great and grateful otherwise

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6 years 8 months ago #695

Hello Miko, yes I have an opinion. I think it's a bad idea based on the mechanisms of resistance. If you think of killing Hep C as being like killing all the enemy soldiers in an area you don't start half hearted, you go in with overwhelming force and kill everyone before (selected resistance) provides an opportunity for the enemy to regroup.

On the more evidence based front patients taking Harvoni (before it even had that name) in the ion-1 trial took the Sof+Led combination from day 1. Why vary from that proven approach?


YMMV
Last Edit: 6 years 8 months ago by DrJames.

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