Hello Miko, yes I have an opinion. I think it's a bad idea based on the mechanisms of resistance. If you think of killing Hep C as being like killing all the enemy soldiers in an area you don't start half hearted, you go in with overwhelming force and kill everyone before (selected resistance) provides an opportunity for the enemy to regroup.
On the more evidence based front patients taking Harvoni (before it even had that name) in the ion-1 trial took the Sof+Led combination from day 1. Why vary from that proven approach?