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HCC and DAAs - Treat the HCC first for better SVR rates

TOPIC: HCC and DAAs - Treat the HCC first for better SVR rates

HCC and DAAs - Treat the HCC first for better SVR rates 2 years 3 months ago #23944

  • DrJames
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This recent journal article observes that patient with HCC are 6 times more likely to fail HCV treatment than patients without liver cancer

On the good news side, it also observes that HCV treatment after curative therapies for HCC resulted in excellent SVR.

www.journal-of-hepatology.eu/article/S01...(17)30053-3/fulltext

I would speculate that the accelerated uncontrolled cellular division present in HCC and the fact that cancer cells ignore the body's apoptosis (literally f*** off and die) signals is why treatment is more effective if you kill of these cells first.
YMMV
Last Edit: 2 years 3 months ago by DrJames.
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HCC and DAAs - Treat the HCC first for better SVR rates 2 years 3 months ago #23946

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Doc - I love the anology: the cancer cells ignore the body's apoptosis literally saying" f_ck off and die! Very well described,thank you.
Contracted HCV 1980's
Geno Type 1a
F3 ( doc says once treated I'll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count - 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!
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HCC and DAAs - Treat the HCC first for better SVR rates 2 years 3 months ago #23964

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Sven wrote:
Doc - I love the anology: the cancer cells ignore the body's apoptosis literally saying" f_ck off and die! Very well described,thank you.

Good analogy too for some big companies as well - thinking of my mobile phone service provider and no one else thanks.

Heading would have been less confronting if the word 'active' was in it!

J.
GT3a 1990 Failed Inter 1998, comb in 2000. HCC 2012
Started 24/52 Sof/Dac 27th October 2015.
1. Bloods 2 October 2015: AST - 165 (20-40), ALT - 265 (5-40), GGT 189 (5-50)
2, Bloods 20 November 2015: ALT etc normal; VL 19
3. Bloods 8 January 2016: AST - 40, ALT - 59, GGT 48 VL RNA UND
4. EOT 12 April 2016 - blood tests: all is well, CT scan: okay
5. AFP 11 June 2016: 4 ref< 11
6. VL July 2016: DET
7. Oct16 start treat - June17 UND
8. Jun 18, lfts okay, platelets a bit low.
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