Sof/Dac has been used in about 1 million Egyptian GT4 patients so there is no doubt it works well. We still have 100% SVR for it in GT2 and last time I looked that was 44/44 so it's pretty solid there. With GT5 and GT6 we also have 100% but the numbers are pretty small - about a dozen patients all up.
At the moment there is no generic Vosevi coming soon that I'm aware of. There have never been generics of AbbVie stuff however that may well change over the course of the next year.