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100% - Dare to Dream The Impossible Dream 6 years 10 months ago #8462

  • DrJames
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The combination of Sofosbuvir and Daclatasvir provided pangenotyic treatment of HVC by inhibiting NS5B and NS5A.

Simeprevir inhibits the NS3A/4 components: en.wikipedia.org/wiki/Simeprevir

If you've been wondering if inhibiting NS3A/4 + NS5A + NS5B might work really well consider the IMPACT study that was reported at the AASLD November 2015 meeting - 100% might well be here:

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Before you get too excited there is no generic Simeprevir currently available and the cheapest price you might find it is for $7500 USD for 3x28 in Egypt, but it does look very promising.

Note that Simeprevir is not active against GT3 and you don't want the Q80K mutation

www.ncbi.nlm.nih.gov/pubmed/22326470

www.ncbi.nlm.nih.gov/pubmed/19852962

www.ncbi.nlm.nih.gov/pubmed/26392483
YMMV
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