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100% - Dare to Dream The Impossible Dream 8 years 4 months ago #8462

  • DrJames
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The combination of Sofosbuvir and Daclatasvir provided pangenotyic treatment of HVC by inhibiting NS5B and NS5A.

Simeprevir inhibits the NS3A/4 components: en.wikipedia.org/wiki/Simeprevir

If you've been wondering if inhibiting NS3A/4 + NS5A + NS5B might work really well consider the IMPACT study that was reported at the AASLD November 2015 meeting - 100% might well be here:

This browser does not support PDFs. Please download the PDF to view it: Download PDF

Before you get too excited there is no generic Simeprevir currently available and the cheapest price you might find it is for $7500 USD for 3x28 in Egypt, but it does look very promising.

Note that Simeprevir is not active against GT3 and you don't want the Q80K mutation



The following user(s) said Thank You: Archer, Paul-Jarman-facebook, isaing4, MonkMed
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