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TOPIC: The Impact Of DAAs on ALT

The Impact Of DAAs on ALT 2 years 7 months ago #12259

  • DrJames
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Guess when the patient started taking DAAs :)


YMMV
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The Impact Of DAAs on ALT 2 years 7 months ago #12320

  • mgalbrai
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BOOM!
I was diagnosed because of high enzymes. My ALT was 225. It had always been the same since I started getting annual physicals at age 50: 45 +/-.
My PCP said that wasn't uncommon in people who liked to drink alcohol-regularly, like all the time.
So, after the 225 wake up call, I quit drinking. A month later, the ALT was 125. Another month: 90. Another two months: 50. The next year's physical: 38.
So, my liver enzymes came down, but very slowly due to HCV.
Knock out the bug...
BOOM!
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G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
Last Edit: 2 years 7 months ago by mgalbrai.
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The Impact Of DAAs on ALT 2 years 7 months ago #12394

  • sabrecat
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"BOOM!"

my ALTs have hovered in the 100's then the 200's for many years; then the big drop with sof/dac.

little wonder it's hard to figure out day to day whether I feel better, not as good as I should, or I have just got older. Been under the weather that long it is taking months to get used to what feeling good feels like.

Maybe it is the suddenness of the change?

yours


J.
GT3a 1990 Failed Inter 1998, comb in 2000. HCC 2012
Started 24/52 Sof/Dac 27th October 2015.
1. Bloods 2 October 2015: AST - 165 (20-40), ALT - 265 (5-40), GGT 189 (5-50)
2, Bloods 20 November 2015: ALT etc normal; VL 19
3. Bloods 8 January 2016: AST - 40, ALT - 59, GGT 48 VL RNA UND
4. EOT 12 April 2016 - blood tests: all is well, CT scan: okay
5. AFP 11 June 2016: 4 ref< 11
6. VL July 2016: DET
7. Oct16 start treat - June17 UND
8. Jun 18, lfts okay, platelets a bit low.
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The Impact Of DAAs on ALT 2 years 7 months ago #12397

  • mgalbrai
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It definitely is not a "magical journey" into the vigor and optimism of my younger years feeling.
But, if I get a good night's sleep, I generally feel as good or better than I have felt in years. No illness so far this school year either. That's simply incredible for me. The past decade, it seemed like I had, or was getting over, a cold or sinusitis the whole time.
Some nights I sleep great. Some nights its like my mind won't "shut off" and the sleep sucks.
Probably age or, as my mother would say, something I ate....
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G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
Last Edit: 2 years 7 months ago by mgalbrai.
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