TOPIC:

Hi there all
Wasn't gonna engage with this thread but replying to Price
Weed was not a drug that I needed or interested me during DAA tx
It helped a lot when a kind breast cancer survivor friend gave me some ONCE during peginf when I was toilet hugging that was in 2012. Fortunately with a healthy lifestyle I am F0.
My anxiety and PTSD are not induced by marijuana use, I had a poor experience with peginf and won't devulge too much on a public forum because I respect others may be triggered by the details of how it went and the ongoing legacies, but thanks very much for thinking of me. I use doctors medicine. I also see a psych and she is super fab. You know the best thing? I'm open about my anxiety I acknowledge it and communicate and seek ongoing support. If I didn't do these things I would be stupid. I'm about living a happy useful life and rebuilding the damage that was done.


EDIT: post number #15345 had my name plonked in the middle of it with asterisks. It has been removed by the writer since! Hence the unusual look of this thread now. Thankyou for your understanding new members who might be reading. Kind regards from Ariel.

PS I don't do C2H6O or C5H12O either
No booze here thanks
Splashes of H2O from Ariel

Marinol is used for nausea. That's a synthetic cannabinoid.

Interferon activates CB1 and studies have shown that PTSD is associated with an increase in CB1 receptors in the brain.

I find it interesting that so many different illnesses are associated with receptor imbalances.

I'll take some splashes, I should be drinking more water

P.

It's not about the receptors but the signaling (or lack of) from the receptors.

But it is about the receptors in the context of the study linked in the OP. The issue is that HCV causes development of extra CB1 receptors in the liver. These extra receptors are responding to THC resulting in increased levels of steatosis and associated fibrosis. In fact part of the feedback loop that appears to be operating is that fibrosis causes increased CB1 expression which in turn causes more fibrosis due to THC exposure. Thus it is definitely not a process that is dynamic and in equilibrium. The take home message from the study seems to be that it would probably be advisable to avoid the use of marijuana if you have HCV rather than that you should try to ameliorate the situation by regulating glucose levels. The latter is a different argument.

Your other links about studies into the harmful effects of marijuana use all cite daily, heavy or high potency users. They are valid in that context but less so with regard to the contributors to this thread who from my reading don't appear to be heavy 'stoners', at least these days. Instead mostly they appear to be people investigating and discussing the above issue in the context of their health and/or the use of social vices in a manner that will be least damaging to their livers both pre and post HCV treatment. Everything we do in life is subject to a risk/benefit analysis whether we recognise it or not.

Gaj wrote:

It's not about the receptors but the signaling (or lack of) from the receptors.

Your other links about studies into the harmful effects of marijuana use all cite daily, heavy or high potency users. They are valid in that context but less so with regard to the contributors to this thread who from my reading don't appear to be heavy 'stoners', at least these days. Instead mostly they appear to be people investigating and discussing the above issue in the context of their health and/or the use of social vices in a manner that will be least damaging to their livers both pre and post HCV treatment. Everything we do in life is subject to a risk/benefit analysis whether we recognise it or not.

(I wasn't even going to be in this thread, but accept any kind intentions)

Thank you Gaj.
And this is where I personally got kinda stumped at the lengthy post naming myself and linking my anxiety (which I believe is best managed with my GP and psych and myself and my integrity) peppered with multiple citations about heavy use of marijuana when I have never profiled as such a person. To use this for a few months occasionally when in and out of hospital because of interferon does not concern me in the slightest. I was thankful for the relief albeit rather late in that tx and I was really past it by then anyway and yes that was...4 years ago. I must say, as a School teacher I would have lost my job and been deregistered if I used that during my 24+ years of service. But then I was diagnosed with HepC...oh and that interferon I wasn't wanting to think about again.... I think this thread is really not about me. I think my stress or whatever you wish to call it is as I said, best managed by my medicos and self, and definitely NOT the product of a occasional relief from loo hugging. Yes water is good. Surfing is good. Sport is excellent. I am a sport junkie. I have drunk enough to get a camel across the Simpson. I leave this thread with that.

Being named in it out of the blue has not pleased me at all. It is quite scary actually, after all if I did try to go back to teaching now and my real identity could be traced I would be stuffed over an incident during peginf in despair. I was not in the thread. I'm interested in being well. Thanks, Ariel.

Ariel, so you are a spinner and a stoner, wow that's a long bow hey lol.

I very rarely smoke these days but do appreciate a pigeon (small pinch into a cone) when I go fishing with the boys. We have the most amazingly fucked up times on these outings and will balance that risk, given that I will be dead for a very long time. I think we would have more chance of drowning from falling out of the boat than doing any long term damage to our livers, lungs or brains. Em

Yup.
I can see me now, Head of a Department hiding behind the shelter sheds with the Year 9s wearing my twinset, pearls and mid length skirt. Then taking a Final year applied theory and composition class for a double. Not.
Yeah Em far out eh! Left field anyone?
PS those fishing trips sound like great bloke bonding time, I love fishing I sold my tinnie around three years ago not, much point having it now the billy lids are adults and Dads upstairs.
Re the THC and my apparent serious issues which I don't have...... What did Dr Suess say?

PS I thought pigeons were those thousands of birds that drove me nuts in St Marks Square when I took the fam to Venice

Then taking a Final year applied theory and composition class for a double.

Hey, not a problem! Just set them this:

"Discuss the Grateful Dead's reference to 'graceful instruments' in New Potato Caboose in the context of Handel's Theodora and then create a short bridge transitioning from the 11/07/'67 Soldiers Field, Chicago version of the first into a Catalonian folk Cobla rendition of the latter using the flabiol (tabor pipe), tambori, tenora and tible."



(.......with thanks for the inspiration to the Music Dept., University of California, Santa Cruz who apparently do employ 'behind the shelter shed' types.)

Fantastic! Gawd I am in the thread (must be salt water on the brain syndrome)
During my Masters I actually did write a piece which compared the bards of the middle ages who would musically tell the "news" as they traveled through Europe with the beat movement of the 1960's and their social commentary. Am I allowed behind the shelter shed for that?

'Course you are......bring that big fiddle of yours, stay up wind of the smoke and we can work through the Jerry Garcia/David Grisman song book. Seeing we're healing our livers enough to be 'Old and in the Way' we may as well do it with some good tunes.

Old And In The Way is one of my favourite all-time albums. I still have a vinyl copy, slightly worn from playing.
Old And In The Gray is also a fantastic album, released in 2002 featuring the surviving members from the original.
Here they are performing the Townes van Zandt classic (slightly dodgy video) -

I had the pleasure of working with Pete Rowan several years ago.

I want GD's "Box Of Rain" to be played at my funeral.
"Such a long long time to be gone
and a short time to be there"
GD trivia - Box Of Rain was the last song GD played before Jerry Garcia left this mortal coil.

Thanks sonix, Old & in the Grey ordered. Somehow I'd missed that.

BOR: such a beautifully poignant song.

I did a terrible job explaining things. What I meant to say is that the same receptors(CB1) that are activated by marijuana are also activated by stress (and by interferon)...and chronic activation of the receptors reduces the number of receptors and that can cause stress intolerance.

I did NOT mean to imply anything else and I'm very sorry if it sounded that way. The last thing I wanted to do was upset anybody.

P