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Twinvir SVR - Results look good 6 years 10 months ago #15933

DrJames
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Of all the generic Harvoni copies Twinvir has been on the market for the longest so it should come as no surprise that the SVR12 results for it are the first to arrive.

And what do they say? Well, I just had a look and the news is good.

First let me mention that making ledipasvir bioavailable is not trivial and that Incepta use the same processes used by Gilead - in other words they have done their homework. I should also mention that like Harvoni, Twinvir is not 100% effective and patients can, will and do fail taking the new DAAs, but....

Our current results indicate Twinvir delivers the same clinical results as Harvoni so if this is your chosen medication chances are SVR will be yours.

YMMV

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Twinvir SVR - Results look good 6 years 10 months ago #15939

tweakmax Offline Elite Member Posts: 256 Karma: 2 Thank you received: 301	So prof gane is right? Important that the ledipasvir is of good quality and twinvir is of good quality The following user(s) said Thank You: Thurl

Twinvir SVR - Results look good 6 years 10 months ago #15942

DrJames
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Hi TM,

Professor Ed Gane was curing people of Hep C before many people on the forum here even knew they had it!

What he has been trying to say in lay language is that Ledipasvir is a BCS class II medication with high permeability but poor solubility.

70% of all medications are BCS class II so the science and technology required to make them bioavailable (ie dissolve and get into the body) are well known. Really well known. Pharmacists were doing it before Gilead the company even existed.

We tested some of the very first Twinvir against Gilead medication from ION-1 and found it equivalent. While it is possible to make a bad generic Incepta do not.

YMMV

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Twinvir SVR - Results look good 6 years 10 months ago #16029

Greedfighter Offline Platinum Member Posts: 610 Karma: 21 Thank you received: 1733	Look, a Twinvir video that includes info on how to buy it! Gt 1a, F0, VL 6.5 million, AST 59, ALT 62 Started Twinvir 1/15/16 6 wk. labs VL UND, AST 27, ALT 20 EOT labs VL UND, AST 23, ALT 19 SVR 16, VL UND, AST 28, ALT 17 SVR 24 , VL UND, 10/8/16 SVR 125, VL UND, 9/22/18 SVR 230, VL UND, 10/3/20 The following user(s) said Thank You: coral, mgalbrai, Meg, GT2

Twinvir SVR - Results look good 6 years 10 months ago #16032

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Wow! Thanks for posting. What a great little video for promoting low cost medication and the broader message. :+1:

G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24

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