Anybody who has been correctly diagnosed as having liver cirrhosis will not find that it is gone right after achieving SVR with a 12 or 12 week treatment of the new DAAs. Or should I say, I have never heard of that happening. The liver is an organ that can regenerate itself. Some people who have had cirrhosis have reported that their level of fibrosis did improve some over time, but they were talking about years, not months. I have heard of others who were not cirrhotic that their liver fibrosis improved a lot over time, as measured by fibroscan.

dt

Yes, it won't just disappear, but there is good reason to be optimistic about fibrosis regression...

SVR After Therapy Reduced Inflammation, Fibrosis in HCV Patients

“The observations of the present study strongly suggest that fibrosis regression, including resolution of cirrhosis, will occur in the vast majority of patients who will achieve SVR with these future therapies.”

At SVR the processes driving fibrosis should stop so things should not get worse and over time there is evidence things improve for many patients.

Hi Em,

Do you have the liver fibrosis score for any of these people from before and after their treatments, as shown by fibroscan or biopsy? Liver function tests alone are not enough to tell us about the extent of liver scarring that there is. I am not prepared to believe that a shrivelled, lumpy cirrhotic liver can regress back to the state of a nice soft elastic unscarred liver in 12 weeks. I would love to be proved wrong about this.

dt

Oh, ok.

I'll tell you where I'm coming from. I think that there is a really good thing happening over there where you are. That message needs to get out and is getting out. But what is most likely to discredit it is if the messengers over-egg the pudding. I've seen some claims which have made me cringe (not talking about you here) and I fear might have made others run for the hills. That's bad because there is so much of value being offered that is helpful, and that will be missed.

So, good news stories and positive thinking, great. I love fairy tales too, but they have their place.

dt

I couldn't agree more! During and after my last stint on ifn I felt like I'd been run over by a Mack truck and it took a long time to get out of that hole. I am excited too by people telling how they feel rejuvenated so quickly after starting treatment. Bring it on!
dt

Accessing these medications might not be as simple as seeing a doctor, going to a pharmacy, and then getting them - but it is entirely possible.

Patients are doing it and the results look good. The absolute proof of SVR24 is not yet available but only because generics have only been available for 6 months. Our testing indicates that the generics are good copies so the only real reason they won't demonstrate similar results is if the real active ingredient happened to be a small manufacturing by product contaminating the active.

This site, the forum, the chat part are just as much about social proof as they are about provisioning good quality information to people with a need to know.

A Google for

"dr james freeman" hepatitis c

www.google.com.au/#q=%22dr+james+freeman%22+hepatitis+c

Will turn up stuff dating back for the last 6 months.

After generic treatment bloods revealed virus not detected. I have F4 cirrhosis and still feel abdo pain have problems with digestion and ulcerative colitis.
I look after my liver and have done so for over a year.
I was wondering if there were a chance for my liver to improve or will it stay the same and possibly move from compensated cirrhosis to decompensated cirrhosis?

Would Milk Thistle help?

Hi I finished 24 weeks of LEDIPASVIR / SOFOSBUVIR on Nov 3rd 2016 and soon to have my 12 week post treatment blood tests. If I am still virus negative then, I am deemed to be cured.
I have chronic cirrhosis, with enlarged spleen and gall bladder so I still feel quite unwell.
In retrospect I think I am improving slowly and can do a few more physical tasks than prior to treatment.
The first improvement I was aware of, only a few weeks into treatment was the 'BRAIN-FOG" I had been trying to function with for DECADES!! had cleared a lot.
I certainly feel better in spirit and now think of myself having a future [ I am 65 ] rather than just struggling to get through the day!
Becoming more and more unwell over the last 20 to 30 years cost me nearly everything I loved. My partner of 10 years, my business of 35 years, even my ability to read a book, my perfect escape of a lifetime abandoned me.
I try and eat well, I still smoke ciggies, and am looking forward to, hopefully feeling a little better each day.
THANK YOU TO Dr JAMES FREEMAN and the FIX HEP C Organisation for this hope of a future, after decades of slowly but surely running out of steam, it means the world to me.

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