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Taking oral medication for toenail fungus
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Taking oral medication for toenail fungus 7 years 1 month ago #22443

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I have picked up a toe nail fungus and oral medication has been recommended. I am now undetected and liver function is normal, Is it alright to take medications that are hard on the liver. What tests should I apply to making this decision?
Diagnosed in 2000, Genotype 1(b), no previous treatment,
Viral Load 90,700, ALT 86, AST 56 (as of Novemeber 15, 2015)
Fibroscan F0
Starting Redemption Sof/Led on February 2, 2016
Thanks to Greg Jeffries, Monkmed , FixHepC and Dr. Freeman

Feb. 29
Week 5 of tx
ALT 23
Undetected

May 26
4 EOT
ALT 25
AST 28

Didn't test for viral load. Will test is July at 12 weeks EOT

August 1
Liver enzymes in normal range
HCV UNDETECTED
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Taking oral medication for toenail fungus 7 years 1 month ago #22448

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The oral antifungals are all a bit toxic. That is because fungal cells are very like human cells and therefore very hard to target without some collateral damage.

That said, these drugs are generally safe and severe liver toxicity is very rare.

One option would be to try intensive topical treatment for a good 3 months plus and use oral treatment only if that fails
YMMV

Taking oral medication for toenail fungus 7 years 1 month ago #22449

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Thanks James. I will try that.
Diagnosed in 2000, Genotype 1(b), no previous treatment,
Viral Load 90,700, ALT 86, AST 56 (as of Novemeber 15, 2015)
Fibroscan F0
Starting Redemption Sof/Led on February 2, 2016
Thanks to Greg Jeffries, Monkmed , FixHepC and Dr. Freeman

Feb. 29
Week 5 of tx
ALT 23
Undetected

May 26
4 EOT
ALT 25
AST 28

Didn't test for viral load. Will test is July at 12 weeks EOT

August 1
Liver enzymes in normal range
HCV UNDETECTED
The following user(s) said Thank You: beaches

Taking oral medication for toenail fungus 7 years 1 month ago #22451

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I have just started using a generic version of loceryl and I'm still alive. Can't comment on its efficacy yet, apparently you have to apply it once a week for 6 to 12 months :ohmy:
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby

Taking oral medication for toenail fungus 7 years 1 month ago #22452

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Thanks. Are you taking the oral med? I don't think the topical poses much problem for the liver, but have been warned that oral medication may. I am going to try a tea tree application to see if that can help before hitting the heavy artillery. I'll keep you posted and thanks for the response.
Diagnosed in 2000, Genotype 1(b), no previous treatment,
Viral Load 90,700, ALT 86, AST 56 (as of Novemeber 15, 2015)
Fibroscan F0
Starting Redemption Sof/Led on February 2, 2016
Thanks to Greg Jeffries, Monkmed , FixHepC and Dr. Freeman

Feb. 29
Week 5 of tx
ALT 23
Undetected

May 26
4 EOT
ALT 25
AST 28

Didn't test for viral load. Will test is July at 12 weeks EOT

August 1
Liver enzymes in normal range
HCV UNDETECTED

Taking oral medication for toenail fungus 7 years 1 month ago #22453

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Thanks. Are you taking the oral med? I don't think the topical poses much problem for the liver, but have been warned that oral medication may. I am going to try a tea tree application to see if that can help before hitting the heavy artillery. I'll keep you posted and thanks for the response.
Diagnosed in 2000, Genotype 1(b), no previous treatment,
Viral Load 90,700, ALT 86, AST 56 (as of Novemeber 15, 2015)
Fibroscan F0
Starting Redemption Sof/Led on February 2, 2016
Thanks to Greg Jeffries, Monkmed , FixHepC and Dr. Freeman

Feb. 29
Week 5 of tx
ALT 23
Undetected

May 26
4 EOT
ALT 25
AST 28

Didn't test for viral load. Will test is July at 12 weeks EOT

August 1
Liver enzymes in normal range
HCV UNDETECTED

Taking oral medication for toenail fungus 7 years 1 month ago #22454

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Loceryl is a topical agent used once a week.

The application time depends on speed of nail growth.

What you expect to see is new health nail growing outwards. Once all the infected nail is gone (ie trimmed off) treat for a bit longer to be sure, but you can see it progressively growing out.
YMMV
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Taking oral medication for toenail fungus 7 years 1 month ago #22455

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I've tried tea tree and various similar things including Chinese herbal medicine but none of then worked for me. :(
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby

Taking oral medication for toenail fungus 7 years 1 month ago #22459

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I'm not anti herbal but things like Loceryl are designed for, and fit for, purpose.
YMMV
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Taking oral medication for toenail fungus 7 years 1 month ago #22464

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Tea tree oil has had great results with treating toe nail fungus. There are clinical trials on this. I too have toenail fungus and now that I'm cured of HCV I'm using tea tree oil.. Dab it on twice a day.. I've really reduced the area affected
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Taking oral medication for toenail fungus 7 years 1 month ago #22465

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I'm glad it's working for you. I never had any luck with it but now I'm inspired to give it another go. Maybe now that my immune system is no longer overworked I'll have more success.
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
The following user(s) said Thank You: cdmazoff

Taking oral medication for toenail fungus 7 years 1 month ago #22485

I've tried the shot, but this stuff works.
It takes as long as it takes for the nails to grow, but, with once daily tx, you will never have those nice, thick, yellow nails again.
Once clear, keep treating before bedtime. The shit is insidious but it can't stand the Nonyx.
The Kera makes them look nice until its gone.
m
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
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Taking oral medication for toenail fungus 7 years 3 weeks ago #22656

I am a chiropodistodiatrist of over 15 years of experience and I have not found Loceryl (amorolfine) to work except for the mildest of surface infections. I have known people to persevere for years without success.
Terbinafine on the other hand invariable works although it might take 8-12 month, in rare cases 18 months. If your GP worries about liver damage he can order liver function tests.
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Taking oral medication for toenail fungus 7 years 3 weeks ago #22661

Hey Zsuzsi, Lovely to see you here and giving advise. Hope you are well. LG
(Sent you a PM) x
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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