Blood tests show ALT 47 (from 0-55), but AST 38 (5-34), and GGT 46 (9-36). VL result not ready yet, 7 more days to wait. I am worried because my impression was that after two weeks, all ALT, AST and GGT should be in the normal range... Could this be an indicator that the treatment doesn't work with me?
Everyone is different. Some people respond faster than others. I took Twinvir also; I got tested at 6 weeks and was undetected for the virus, and enzymes in normal range. Most people don't get tested until 4 weeks of treatment. You have nothing to worry about. Hopefully after 4 weeks you are either undetected for the virus or close to it.
It was a different lab, still ALT was 52 (5-31), AST 35 (5-32), GGT 49 (5-36). Didn't make the test for HVB, but I made a test and vaccination few years ago and generally the liver tests were not bad or changing dramatically lately, I don't think it can be a co-infection.
I do hope it will work, having a low VL (2650), I expected to have better tests results in W2, that's why I was a bit scared...
Elena it is waaaaaay to early to start saying that! Seriously. It is imperative that you keep an attitude that says"I'm trying my best, I'm with the best people possible and what will happen is what will happen". I say this because we all felt issues of doubt, because your viral load is so low there is not much lower you can go, so it may go slower.
You are in the company of the best HCV doctor world wide, if you don't do it the 1st time the next go round will hit it out of the park.... BUT you got it this time, let it work.
In good health to you
Contracted HCV 1980's
Geno Type 1a
F3 ( doc says once treated I'll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016
Viral count - 3,471,080
4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)
8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)
We do normally see a good drop of ALT/AST. In you we have not seen that, which raises the question if it is not HCV (and if we do a viral load I expect you to be undetected) what is the cause?
Although it is rare with Sofosbuvir/Daclatasvir with drugs like Viekira and Zepatier it is very common to see liver functions get worse on treatment. This is a reaction to the drugs so it is possible that Twinvir itself is causing it.
Anyway it is nothing to panic about, but does need looking into further, probably after you finish the Twinvir.
ALT, AST and GGT still a little bit higher than normal, but this is something I will take care of after the treatment.
I am now thinking about the duration of the treatment: as my VL before treatment was very low - 2500, and I was naive patient, I am thinking to stop the treatment after 8 weeks instead of 12, any advice/thoughts/information on this?
Congratulations on your great results.
You will benefit from medical advice on this but my personal view is to continue for the whole treatment. Relapse occurs in a small percentage of people and a few extra weeks (i.e. the full treatment) will give you the very best chance of being cured forever as well as peace of mind in the weeks following cessation of treatment.
Best wishes for the remainder of your treatment.
G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24
Too many lives go into the making of just one. - Montale
Thank you received: 223
G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!