I have just read through the new EASL guidelines and found that the Sof/Dac combo is no longer being recommended for G3. In his blog Greg Jeffrys claims that the real world results for this treatment were not as good as the trial results with SVR obtained in 80% of cases after 12 weeks and 90% after 24 weeks.
Well it worked for me so I'm not complaining but would anyone like to comment?
G3a. Probably infected 40 years ago.
Diagnosed July 2015
7/7/2015: ALP 69, ALT 209, WBC 5.8, VL 40,000. Fibroscan 9.5 Kpa.
Commenced treatment Sof/Dac (Natco Pharma) 24 wks in Feb 16
VL UND @ 4 wks, 12 wks
PHEW! Thank you so much Dr James, Monkmeds and all at Fixhepc
Vindecat de HCV cu med. generice. Cured with generics HCV drugs.
Thank you received: 1594
Perhaps a little bit off-topic, but I think it is the first time when we may see a clear message in the Easl journal that generics provide similar results as original compounds:
Licensed generic drugs and drugs agreed with the Medicines Patent Pool have been shown to generate similar results to the original compounds. The presence of the drug at the appropriate dosage must be verified by the provider and guaranteed
to the prescriber and patient. Indeed, effective and safe generics are a crucial resource in resource-limited countries.
In fiecare an HCV ucide peste 500000 oameni.Medicamentele generice pentru hepatita C functioneaza. Nu deveni statistica! Cauta pe Google “medicamente generice pentru hepatita C”.
HCV kills more than 500000 people every year. HCV generic drugs work. Don't become a statistic.
By sharing this Youtube video you might save someone’s life!
My TX: HEPCVIR-L[generic Harvoni]-India
Sof Dac did not get me over the line first time around though it made me feel better while taking it.
Adding the dreaded Ribavirin second time round made the difference - I hope still SVR as the next blood test is in June. Have to add my liver had seen better days as well.
GT3a 1990 Failed Inter 1998, comb in 2000. HCC 2012
Started 24/52 Sof/Dac 27th October 2015.
1. Bloods 2 October 2015: AST - 165 (20-40), ALT - 265 (5-40), GGT 189 (5-50)
2, Bloods 20 November 2015: ALT etc normal; VL 19
3. Bloods 8 January 2016: AST - 40, ALT - 59, GGT 48 VL RNA UND
4. EOT 12 April 2016 - blood tests: all is well, CT scan: okay
5. AFP 11 June 2016: 4 ref< 11
6. VL July 2016: DET
7. Oct16 start treat - June17 UND
8. Jun 18, lfts okay, platelets a bit low.
I had 12 wks of Sof/Doc for GT3, and it seemed to work: SVR at 16 wks. But about 18 months later I found that I had relapsed, so I was probably in the wrong end of the 90% at 24 wks category. Because I felt absolutely fine after 1 year, I did not bother getting a final VL test. With hindsight, this was a mistake.
With all the success stories here, it now seems like overkill to do a lot of testing while on treatment, but doing 12, 24 and 48 week post-tx tests would still be wise...
Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
Week4: AST 47, ALT 58. VL < 15 (unquantifiable).
Week12 (EOT): AST 30, ALT 26, VL UND
Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND
Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND
Ever grateful to Dr James.