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Dr James with COVID-19 research. 2 years 5 months ago #28942

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Hi friends,

This very important pre print article www.biorxiv.org/content/10.1101/2020.06.15.153411v1.full

shows great results in lab testing for hep C drugs like daclatasvir for treating COVID-19.

Have a look in the acknowledgments for Dr James Freeman and Dr Andrew Hill and expect more news published over the next few weeks.
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
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Dr James with COVID-19 research. 2 years 5 months ago #28943

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Thanks for posting it Hazel
YMMV
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Dr James with COVID-19 research. 2 years 5 months ago #28945

Good to see your name up in lights Doc
TLDR
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Last edit: by jimmy42. Reason: spelling

Dr James with COVID-19 research. 2 years 5 months ago #28947

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Hey Jimmy42,

Long time big fella! How is life treating you?

There should be a bit of interesting news vis a vis HCV medication vs COVID-19 in the near future.
YMMV
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Dr James with COVID-19 research. 2 years 5 months ago #28949

www.biorxiv.org/content/10.1101/2020.06.25.169946v1

Sounds V messy for the brain too,
USA govt is lost in the woods as usual can't see any trees, lucky I'm not in USA, feel sorry for those ppl there,
What have they offered so far ,,, Hydroxychloroquine,,, Remesdevir,,, Bleach,,

"These results provide evidence for the neuroinvasive capacity of SARS-CoV2, and an unexpected consequence of direct infection of neurons by SARS-CoV2."
TLDR
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Dr James with COVID-19 research. 2 years 4 months ago #28965

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HCV has a direct neuroinvasive effect as well, as many of us will attest after getting our wits back post treatment.

This SARS-CoV-2 thing is really looking like much more than a simple Coronavirus, almost like a hybrid of different pathogens which are quite nasty on their own.

Once again, Jimmy, the "bleach" nonsense is a media fabrication. Please stop repeating it.
Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!
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Dr James with COVID-19 research. 2 years 4 months ago #28967

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Today is a big day! Tony Fauci headlines for the research and trials Dr James has been the pivotal coordinator of all this:

publicaddress.net/hardnews/more-on-the-r...tis-c-drugs/?fbclid=

www.ft.com/content/ce38f292-b952-42c6-aaab-c8bdbe964c92?fbclid=

covid19.aids2020.org/2020/07/09/breaking...covid-19-conference/
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
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Dr James with COVID-19 research. 2 years 4 months ago #28971

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Seriously, this is a big deal.

Dr James and a small group of clinicians and researchers have set up this network of trials, following on from the just-released Iran data - which!!!!!
has also been selected as one of five clinical highlights selected by Anthony Fauci from the IAS virtual COVID-19 workshop that will take place directly after AIDS2020.

And now appears in many articles worldwide such as the esteemed MedPage here

www.medpagetoday.com/infectiousdisease/covid19/87520?fbclid=
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
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Dr James with COVID-19 research. 2 years 4 months ago #28974

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Hi Hazel, getting this work selected and labeled by Anthony Fauci as potential treatment for Covid-19 sure is a big deal, huge kudos to Dr James for his contributions to this work. If the larger trials in Brazil, Egypt and South Africa confirm the results of the small Iranian trial results, Dr James will have every right to put under his Facebook profile "saved the world" :cheer:
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Last edit: by Mar.

Dr James with COVID-19 research. 2 years 4 months ago #28975

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This is really exciting stuff. Thanks Doc!
Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!
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Dr James with COVID-19 research. 2 years 4 months ago #28978

Thank you! Dr. James cured my hepc. I see my doc on Thurs. for Covid-19. I'll see what my doc says if I am positive. Been pretty sick. She remembers Dr. James.

Either way, thank you all.

Lilyfield
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Dr James with COVID-19 research. 2 years 4 months ago #28979

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Hi Lilyfield, sorry to hear that. I'm not a doctor but have read that Dr James recommends 'Indomethacin' to people who are suspected of having Covid-19 (at least until you see your doctor). It's an NSAID (similar to Aspirin) with 3 very important benefits if given early on. The first and most important is that it's a blood thinner (will reduce the chances of Covid-19 most serious complication, blood clots). It should not be taken however if you're already taking another blood thinner. Second, it's an anti-inflammatory (will reduce the immune system over reaction). Third, it's a fever reducer. There is evidence that it also inhibits virus replication.

Indomethacin is very cheap and in many countries it's an OTC drug (requires a prescription in the US though). More potent medications will be given of course if the disease is not mild, but early on, or until you see a doctor, it seems like an excellent medication to take especially that it has the same side effects profile as Aspirin.
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Dr James with COVID-19 research. 2 years 3 months ago #28988

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The data about Indometacin comes from several sources.

It was first observed to work for SARS in Italy and that's described here: fixrx.com/coronavirus-indomethacin-to-the-rescue/

The Chinese repeated that study in SARS-CoV-2 www.biorxiv.org/content/10.1101/2020.04.01.017624v1

In NYC Dr Jonathan Leibowitz tried it out on patients:

medicalupdateonline.com/2020/05/indomethacincovid19/

And reported on it in the medical literature here:

www.bmj.com/content/368/bmj.m1185/rr-3
YMMV
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Dr James with COVID-19 research. 2 years 3 months ago #28998

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Journal published author, Dr James in this groundbreaking study into the use of the hep C antivirals for COVID-19.
Lots more to come on this over the next 8 weeks or so.

academic.oup.com/jac/advance-article/doi.../jac/dkaa331/5889946?
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
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