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Ledipasvir-sofosbuvir safe, effective for older HCV patients 8 years 4 weeks ago #13947
www.pharmacist.com/ledipasvir-sofosbuvir...e-older-hcv-patients A new study has found that a ledipasvir–sofosbuvir combination is safe and effective for older individuals with genotype 1 hepatitis C virus (HCV) infection. A new study has found that a ledipasvir–sofosbuvir combination is safe and effective for older individuals with genotype 1 hepatitis C virus (HCV) infection. Researchers analyzed sustained virological response at 12 weeks and monitored adverse events, comparing a sample of nearly 2,300 patients aged 65 years and older with a group younger than 65 years. At 12 weeks, 97% of the younger patients and 98% of those aged 65 years and older achieved sustained virological response. The most common adverse events were headache and fatigue. The findings are published in Hepatology. Reuters Health (03/22/16) Janeczko, Lorraine www.medscape.com/viewarticle/860594 Genotype 1A ALT 473 AST 226 Virus Load 3,119,030 Results as of May-2016 5 week viral load/undetected as of 12/02/2016 Liver Biopsy Results from Feb 2013 Portal/Periportal chronic inflammation and mild interface hepatitis (Grade 2) Focal Lobular chronic inflammation (Grade 1) Portal/Periportal fibrosis (stage 1-2 trichrome and reticulin stains utilized) Negative Iron stains. | |
Ledipasvir-sofosbuvir safe, effective for older HCV patients 8 years 4 weeks ago #13952
| Hi Tommy, I'm 67 years old & today I just finished 168 days of Sofosbuvir / Ledisbovir , plus 84 days Ribavirin. I struggled with the Ribavirin side effects but just managed to stay on the full dose of 1200mg. The last 4 weeks of treatment I suffered a lot of joint & muscle pain. Also feeling fatigued most days. Now it's a wait for SVR 4 & SVR 12 & SVR 24 AUSTRALIAN HCV Genotype 1a 2003 Relapsed Peg Interferon / Ribavirin Pre treatment VL 2,000,000 ALT 65, AST 42, ALP 111, GGT 56 Bridging F3-4 Treatment -24 weeks - Sof , Led with 12 weeks Riba. 4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14 12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20 24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14 EOT 6th April 2016 SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20 |
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