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TOPIC: Ledipasvir-sofosbuvir safe, effective for older HCV patients

Ledipasvir-sofosbuvir safe, effective for older HCV patients 2 years 10 months ago #13947

  • Tommy
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www.pharmacist.com/ledipasvir-sofosbuvir...e-older-hcv-patients

A new study has found that a ledipasvir–sofosbuvir combination is safe and effective for older individuals with genotype 1 hepatitis C virus (HCV) infection.
A new study has found that a ledipasvirā€“sofosbuvir combination is safe and effective for older individuals with genotype 1 hepatitis C virus (HCV) infection. Researchers analyzed sustained virological response at 12 weeks and monitored adverse events, comparing a sample of nearly 2,300 patients aged 65 years and older with a group younger than 65 years. At 12 weeks, 97% of the younger patients and 98% of those aged 65 years and older achieved sustained virological response. The most common adverse events were headache and fatigue. The findings are published in Hepatology.

Reuters Health (03/22/16) Janeczko, Lorraine

www.medscape.com/viewarticle/860594
Genotype 1A
ALT 473
AST 226
Virus Load 3,119,030
Results as of May-2016
5 week viral load/undetected as of 12/02/2016
Liver Biopsy Results from Feb 2013
Portal/Periportal chronic inflammation and mild interface hepatitis (Grade 2)
Focal Lobular chronic inflammation (Grade 1)
Portal/Periportal fibrosis (stage 1-2 trichrome and reticulin stains utilized)
Negative Iron stains.
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Ledipasvir-sofosbuvir safe, effective for older HCV patients 2 years 10 months ago #13952

Hi Tommy,
I'm 67 years old & today I just finished 168 days of Sofosbuvir / Ledisbovir , plus 84 days Ribavirin.
I struggled with the Ribavirin side effects but just managed to stay on the full dose of 1200mg.
The last 4 weeks of treatment I suffered a lot of joint & muscle pain.
Also feeling fatigued most days.
Now it's a wait for SVR 4 & SVR 12 & SVR 24
AUSTRALIAN
HCV Genotype 1a
2003 Relapsed Peg Interferon / Ribavirin
Pre treatment VL 2,000,000
ALT 65, AST 42, ALP 111, GGT 56
Bridging F3-4
Treatment -24 weeks - Sof , Led with 12 weeks Riba.
4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14
12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20
24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14
EOT 6th April 2016
SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20
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