Welcome, Guest
Username: Password: Remember me

TOPIC:

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20374

  • Hazel
  • Hazel's Avatar
  • Offline
  • Platinum Member
  • Platinum Member
  • Posts: 414
  • Karma: 39
  • Thank you received: 1699
follow up to last weeks BMJ, incomprehensible apologists from Gilead respond:

www.statnews.com/pharmalot/2016/08/03/gi...-back-report-pricing
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
The following user(s) said Thank You: coral, Ariel, Gaj, A.L., fitz

Please Log in or Create an account to join the conversation.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20376

Government.....
That is the subject I teach.
Yet, I've been reminded this is not the place to share my personal feelings in that arena....
They (governments) could solve this issue, but WE CAN't EVEN GET BASIC ZIKA FUNDS THROUGH OUR TOTALLY FUCKED UP CONGRESS!
pardon my language.
m
This email address is being protected from spambots. You need JavaScript enabled to view it.
forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
The following user(s) said Thank You: Paul-Jarman-facebook, A.L., Greedfighter, fitz

Please Log in or Create an account to join the conversation.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20378

  • coral
  • coral's Avatar
  • Offline
  • Platinum Member
  • Platinum Member
  • Posts: 605
  • Karma: 38
  • Thank you received: 1811
Thanks Hazel. Interesting article with Gilead trying to defend the indefensible. I'm not sure how they can use the risk factor of the initial investment and lack of government funding as justification for their current and ongoing outrageous pricing model. I understand Gilead's need to fund research and be a profitable business but not with such an obscene profit margin at the expense of so many lives.
G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24
The following user(s) said Thank You: mgalbrai, Ariel, Gaj, Hazel

Please Log in or Create an account to join the conversation.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20379

  • Gaj
  • Gaj's Avatar
  • Offline
  • Moderator
  • Moderator
  • Optimist :-)
  • Posts: 1436
  • Karma: 32
  • Thank you received: 3082
In the case of lack of government funding they just lie. :angry:

[UPDATE: We should note Appendix 2 on page 24 of this report lists National Institutes of Health grants to Pharmassset and its former chief executive before the sale to Gilead].


Edit: can't seem to create a linky in a quote so 'this report' is freepdfhosting.com/e8476beb4e.pdf
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
The following user(s) said Thank You: coral, Vororo, mgalbrai, Ariel, Hazel, Fara, fitz

Please Log in or Create an account to join the conversation.

Last edit: by Gaj.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20380

The corporations have gone wild with unbridled greed, I place blame with the political finance laws. They can legally bribe the politicians, so of course our government says nothing to reign them in. In USA we are totally screwed, there are almost no regulations on business anymore.
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
The following user(s) said Thank You: mgalbrai, Ariel, fitz

Please Log in or Create an account to join the conversation.

Last edit: by Greedfighter.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20390

  • Hazel
  • Hazel's Avatar
  • Offline
  • Platinum Member
  • Platinum Member
  • Posts: 414
  • Karma: 39
  • Thank you received: 1699
Very surprised my comment survived moderation on that article. Earlier there were only ones supporting the price.
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
The following user(s) said Thank You: A.L., fitz

Please Log in or Create an account to join the conversation.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20392

Greedfighter wrote: In USA we are totally screwed, there are almost no regulations on business anymore.


You obviously didn't get the memo, it's not called regulation anymore it's red tape and should be removed according to many politicians ! The USA isn't the only country suffering from this condition.
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
The following user(s) said Thank You: mgalbrai, Gaj, A.L.

Please Log in or Create an account to join the conversation.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20398

  • DrJames
  • DrJames's Avatar Topic Author
  • Offline
  • Platinum Member
  • Platinum Member
  • Posts: 1980
  • Karma: 111
  • Thank you received: 7261
Those who cannot remember the past are condemned to repeat it

- George Santayana

Across the course of history there have been some bad things happen. People in power, and alive at the time have put in place "red tape" to try to prevent future generations having the same issues. Over time memory fades and the voices for change gather momentum.

Take BREXIT for example. As imperfect as the European Union might be the 70 year period of relative peace and prosperity that follows WWII has no parallel in history. Prior to that European countries were routinely at war with each other.

Take Donald Trump as another example, his nationalism and plan for a wall to keep Mexicans out - the parallels to Hitler pre WWII should be evident to any student of history.

Take the whys and wherefores of the US housing meltdown: www.huffingtonpost.com/robert-weissman/d...he-fina_b_82639.html

Here's a great article from the Harvard Business Review: hbr.org/2009/07/shareholders-first-not-so-fast

In the 1950s and 1960s, the stakeholder was king. CEOs saw their role as one of balancing the interests of the various groups that touched their companies—customers, employees, suppliers, shareholders, and the community at large. This reflected the executives’ sophisticated understanding not only of their role as stewards of the valuable resources entrusted to them but also of their own enlightened self-interest: Each of these groups was essential for organizational success. What was true then is even more so today, in an age of knowledge work, outsourcing, global supply chains, and activist interest groups.
YMMV
The following user(s) said Thank You: coral, Vororo, re_roll, A.L.

Please Log in or Create an account to join the conversation.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20400

  • beaches
  • beaches's Avatar
  • Offline
  • Platinum Member
  • Platinum Member
  • The life you save will be your own. START TREATMENT
  • Posts: 760
  • Karma: 25
  • Thank you received: 2254
These days it's not about the stakeholder at all.
It's about that small gentleman's club (and the occasional token lady.... still!) getting their obscene bonuses.
Bastards.
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
The following user(s) said Thank You: Ariel, Gaj, A.L., fitz

Please Log in or Create an account to join the conversation.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20403

  • Gaj
  • Gaj's Avatar
  • Offline
  • Moderator
  • Moderator
  • Optimist :-)
  • Posts: 1436
  • Karma: 32
  • Thank you received: 3082

In the 1950s and 1960s, the stakeholder was king. CEOs saw their role as one of balancing the interests of the various groups that touched their companies—customers, employees, suppliers, shareholders, and the community at large.


Another interesting comparison is the monetary rewards of then versus now. I wonder if their performance has increased commensurately?

The ratio of CEO-to-worker pay has increased 1,000 percent since 1950, according to data from Bloomberg. Today Fortune 500 CEOs make 204 times regular workers on average, Bloomberg found. The ratio is up from 120-to-1 in 2000, 42-to-1 in 1980 and 20-to-1 in 1950.


www.huffingtonpost.com/2013/04/30/ceo-to...ratio_n_3184623.html
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
The following user(s) said Thank You: beaches, A.L., fitz

Please Log in or Create an account to join the conversation.

Last edit: by Gaj.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20404

  • re_roll
  • re_roll's Avatar
  • Offline
  • Premium Member
  • Premium Member
  • Posts: 130
  • Karma: 5
  • Thank you received: 365

James-Freeman-facebook wrote:
Take the whys and wherefores of the US housing meltdown


If one gets the chance, see the movie "The Big Short"....a great flick.
contracted Gen 1a in the 70's, dx in 2007...ast 27 to 35...alt 43 to 96...vl 1.2 mil to 8.6 mil.
biopsy F-2 (2012)..pre tx results 1/23/16 ast 32, alt 46, vl 3.1 mil
tx started 2/11/16.... lab results 2/24/16 ast 18, alt 18, vl <15 IU/ml
28 days later.............lab results 3/9/16 ast 21, alt 21, vl UND
56 days later.............lab results 4/6/16 ast 20, alt 22, vl UND
139 days later...........lab results 6/29/16 ast 28, alt 30, vl UND...EOT
SVR24
The following user(s) said Thank You: fitz

Please Log in or Create an account to join the conversation.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20405

  • A.L.
  • A.L.'s Avatar
  • Offline
  • Senior Member
  • Senior Member
  • Posts: 67
  • Karma: -13
  • Thank you received: 29
And yet, many of us here have bought drugs legitimately, from companies with licences tied to Gilead, for much lower prices than the Western RRP.

Why are people only criticising from one side when we have done so well with Gilead's own cut-price drugs? I've mentioned this many times, but no-one seems able to accept that they got very good deals from the company they are attacking.

Yes, they are greedy, but they also allow this wide open back door that anyone with half a brain, thanks to the work of this site, has been able to make use of.

So please keep your arguments balanced, especially when you start praising other companies that pirate the drugs and have made relatively little investment into research apart from getting the manufacture right. They are the real bottom-feeders (but all the same, I have some respect for their criminal professionalism in delivering even cheaper drugs to the market.)

It's a complex issue that doesn't yield much to the logic of dedicated witch hunters and other overly idealistic commentators.
G4, F4, cirrhosis.

Thank you to Gilead, Michael Sofia, and the terrific folk at FixHepC for making this adventure possible.

YEAR..... ALT..... AST..... GGT... FERRITIN........................................
2009....... 210..... 215..... 953..... 1400........... (Bad health, stupidity)
2015....... 60....... 45....... 150..... 360............. (Improved diet and health, FixHepC treatment)
2016....... 20....... 24....... 25....... 156............. (SVR 12)

Please Log in or Create an account to join the conversation.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20407

  • fitz
  • fitz's Avatar
  • Offline
  • Platinum Member
  • Platinum Member
  • Cured with generic DAAs. Hep C kills. Treat now!
  • Posts: 501
  • Karma: 23
  • Thank you received: 1816
The 'housing' meltdown in the US started when it became apparent that the biggest mortgage insurer (MBIA) couldn't possibly cover its bets. This ultimately sent investors running for the exits, and the entire house of cards, and the economy along with it came crashing down.

Something similar is happening now with insurers underpinning the Affordable Care Act (Obamacare). They are literally running for the exits. Whatever happens from here forward is likely not going to be pretty.
Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!
The following user(s) said Thank You: Meg

Please Log in or Create an account to join the conversation.

Last edit: by fitz.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20409

  • Gaj
  • Gaj's Avatar
  • Offline
  • Moderator
  • Moderator
  • Optimist :-)
  • Posts: 1436
  • Karma: 32
  • Thank you received: 3082
Hi A.L.,

Of course the problem with your argument is that it is not "Gilead's own cut price drugs" that people here are using but mostly Indian and a few Bangladeshi manufactured drugs enabled by the fact that India didn't and Bangladesh isn't required to recognise a Gilead patent.

Gilead only provided a licence to some of the manufacturers after it realised it was unlikely to achieve the patent control it had applied for in an attempt to harvest some income from the situation. The fact that they have subsequently acquired patent in India is irrelevant to why we can access these medications.

And they certainly don't "allow this wide open back door" as you state. In fact they attempted to apply rules of supply such as "bottle return before prescription refill" to their licencees to prevent this occurring. Thankfully they have not been very successful in doing that.

Nor have Gilead invested a great deal into research in this case, instead they took a gamble on other's investments in that area. How much that was truly a gamble can probably be gauged by the 11 billion they overpaid for an asset that the market valued at 7 billion at the time. You could possibly call it an astute or more correctly clever investment but it is one which they have used to price gouge the sick around the world ever since.

By the way, your use of belittlements such as "dedicated witch hunters" in what appears to be a thinly veiled attempt to inflame participants of this discussion does nothing to inform your argument or your audience.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
The following user(s) said Thank You: Vororo, beaches, Greedfighter, fitz

Please Log in or Create an account to join the conversation.

Last edit: by Gaj.

Pharmasset Development Costs vs Gileads Profits 6 years 3 months ago #20410

Anything, ANYTHING the government does, they do poorly, and with great inefficiency.
This email address is being protected from spambots. You need JavaScript enabled to view it.

Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
The following user(s) said Thank You: Meg, fitz

Please Log in or Create an account to join the conversation.

Time to create page: 0.075 seconds

Copyright © 2015-2020 FixHepC

Back to Top