TOPIC:

Just had my results 14 weeks EOT
Negative for Hep C
Thanks Dr Freeman

Good for you!!!!!

Good news Donna another one cured

I can't wait to start. I want to get my fibroscan and have doctor prescribe so I can get in on the studies. I have had most tests done. Thankfully the two listed on this site are good and affordable. I have type 3A. My scan is in one month. It is cheaper for me to go to Canada to get this as I do not need doctor appointments for it. I hope to see updates on your progress.

Hi Gypsy, This is an exciting time for you, you must be full of anticipation. Good that you do not have to wait long until you get your fibroscan, you're fortunate to be able to access that technology. As a longtime HCV+ve person who endured multiple old liver punch biopsies, I was relieved when the far more comfortable fibroscanning became available.
I am looking forward to reading your progress reports over the next weeks and months. You are on your way!

Hi Gypsy,

Good to see that you are heading towards your start date. I know what you mean about not wanting to wait. Once I heard about the treatment and how quickly, easily and cheaply I could access it I couldn't wait to just do it. Good luck and I'm looking forward to hearing about how you are travelling.

I got my Rx through Dr . Freeman and they were shipped and are now in New York (customs I suppose). Fibroscan is this next week. Looking forward to results. Going to Canada which is at least a 7 hr trip or longer. Cant wait to get started.

Yay!!Yahoo!! Congratulations!

Hi James Feemann

Treatment of GT3 in Denmark:

I have a question for you regarding genotype 3
Have the Danish health authorities paid the following treatment:
Sofosbuvir 400 mg & Velpatasvir 100 mg or
Sofosbuvir 400 mg & Daclatasvir 60 mg.

Are there any studies whether there are differences in the effect of the two types of treatment?

greeting
Gert

Hello Gert,

Yes, there are studies. You want page 18 of the EASL Guidelines (see PDF) that reports the major studies used for the guidelines and provides references for them you can then look up.

SOF+VEL: ASTRAL-3

Short version: slides.hcvonline.org/uploads/194/astral3.pdf
Long version: www.nejm.org/doi/full/10.1056/NEJMoa1512612#t=article

SOF+DCV: ALLY-3 and ALLY-3+

Short version: slides.hcvonline.org/uploads/164/ally3.pdf
Long vesion: www.ncbi.nlm.nih.gov/pmc/articles/PMC4409820/

ALLY-3+ www.ncbi.nlm.nih.gov/pubmed/26822022

There is another bigger SOF+DCV trial here: fixhepc.com/forum/gt3/369-gt3-high-svr-r...ith-daclatasvir.html which includes a PDF of the results. It does not have a funky name AFIK.



You may notice that the results for SOF+DCV vary a bit and include similar optimistic numbers to SOF+VEL

Now this table is interesting (and you won't easily find it). It comes from Abbvie who were talking about how good G/P is (previously called ABT-493/ABT-530). GS-9857 is Voxilaprevir in case you're wondering.



In theory Velpatasvir should be better - It has an EC50 of 20 vs 530 for daclatasvir, but only about 25% gets absorbed so that robs it of part of the 26.5x theoretical edge, dropping it to say 7x, but then the dose is 100 mg vs 60 mg so that pushes it up to about 10x.

Now resistance comes in 10x, 100x and 1000x strengths so 10x is just enough to probably make a real difference for a few patients.

I have no doubt that 16 weeks SOF+DCV works better in GT3 patients than 12 weeks, so that is a factor.

I am genotype 3A and have been generic epclusa only a little over a week. My fibroscan looked normal. The first few days I felt kind of off but take it at night now and am noticing improvement in energy off and on.

Hi I'm genotype 3 have been positive for 18 years, no scarring shown on fibroscan, no past treatment, and am about to start sofosbuvir and daclatasvir.

MWILLIAMS wrote: Hi I'm genotype 3 have been positive for 18 years, no scarring shown on fibroscan, no past treatment, and am about to start sofosbuvir and daclatasvir.

Welcome MWILLIAMS, that's a good treatment. Chances are good it will cure you.

Thanks. I've been waiting a long time for a cure and now that I have the treatment I'm a bit anxious to take it