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TOPIC: Genotype 3's info, updates corner

Genotype 3's info, updates corner 5 years 2 months ago #23987

Donna Offline Senior Member Posts: 71 Thank you received: 215 Karma: 3	Just had my results 14 weeks EOT Negative for Hep C Thanks Dr Freeman
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Genotype 3's info, updates corner 5 years 2 months ago #23988

splitdog
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Good for you!!!!!

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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James

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Genotype 3's info, updates corner 5 years 1 month ago #24002

Paul-Jarman-facebook Offline Moderator The gypsy woman told my mother Before I was born Posts: 383 Thank you received: 659 Karma: 9	Good news Donna another one cured
	Two time relapser. SVR 4 achieved 12/16 at last SVR 12 achieved 22/02/2017 The Bastard has been defeated GT 3 - about 28 yrs with HCV The administrator has disabled public write access. The following user(s) said Thank You: DrJames, Donna

Genotype 3's info, updates corner 5 years 3 weeks ago #24274

gypsy Offline Senior Member Posts: 57 Thank you received: 97 Karma: 2	I can't wait to start. I want to get my fibroscan and have doctor prescribe so I can get in on the studies. I have had most tests done. Thankfully the two listed on this site are good and affordable. I have type 3A. My scan is in one month. It is cheaper for me to go to Canada to get this as I do not need doctor appointments for it. I hope to see updates on your progress.
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Genotype 3's info, updates corner 5 years 3 weeks ago #24275

Mnem
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Too many lives go into the making of just one. - Montale
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Hi Gypsy, This is an exciting time for you, you must be full of anticipation. Good that you do not have to wait long until you get your fibroscan, you're fortunate to be able to access that technology. As a longtime HCV+ve person who endured multiple old liver punch biopsies, I was relieved when the far more comfortable fibroscanning became available.
I am looking forward to reading your progress reports over the next weeks and months. You are on your way!

G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!

Last Edit: 5 years 2 weeks ago by Mnem. Reason: spellings

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Genotype 3's info, updates corner 5 years 3 weeks ago #24284

coral
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Hi Gypsy,

Good to see that you are heading towards your start date. I know what you mean about not wanting to wait. Once I heard about the treatment and how quickly, easily and cheaply I could access it I couldn't wait to just do it. Good luck and I'm looking forward to hearing about how you are travelling.

G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24...

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Genotype 3's info, updates corner 4 years 11 months ago #24493

gypsy Offline Senior Member Posts: 57 Thank you received: 97 Karma: 2	I got my Rx through Dr . Freeman and they were shipped and are now in New York (customs I suppose). Fibroscan is this next week. Looking forward to results. Going to Canada which is at least a 7 hr trip or longer. Cant wait to get started.
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Genotype 3's info, updates corner 4 years 11 months ago #24494

gypsy Offline Senior Member Posts: 57 Thank you received: 97 Karma: 2	Yay!!Yahoo!! Congratulations!
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Genotype 3's info, updates corner 4 years 11 months ago #24503

Gert
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Born in Copenhagen, live in AArhus Denmark
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Hi James Feemann

Treatment of GT3 in Denmark:

I have a question for you regarding genotype 3
Have the Danish health authorities paid the following treatment:
Sofosbuvir 400 mg & Velpatasvir 100 mg or
Sofosbuvir 400 mg & Daclatasvir 60 mg.

Are there any studies whether there are differences in the effect of the two types of treatment?

greeting
Gert

Probably infected 30 years ago Genotype: 1a
Fibroscan 4,8 - 18 january 2017
Virus in the blood 18 January 2017 10.400000 / Alat 102
Started treatment January 19, 2017
Feb.15 - Alat 76 - virus: UNDETECTED
March 15 - Alat 34 - virus UNDETECTED
April 12 - Alat 40 Asat 34 - virus UNDETECTED / Taking the last pill
May 10 SVR4 - Alat 36 -virus UNDETECTED
July 5 SVR12 - Fibroscan 3,8 Alat 39 - virus UNDETECTED
Sep. 27 SVR24 - ALAT 24- virus UNDETECTED
Marts 14 - 2018 SVR48 - ALAT 26- virus UNDETECTED

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Genotype 3's info, updates corner 4 years 11 months ago #24506

DrJames
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Hello Gert,

Yes, there are studies. You want page 18 of the EASL Guidelines (see PDF) that reports the major studies used for the guidelines and provides references for them you can then look up.

SOF+VEL: ASTRAL-3

Short version: slides.hcvonline.org/uploads/194/astral3.pdf
Long version: www.nejm.org/doi/full/10.1056/NEJMoa1512612#t=article

SOF+DCV: ALLY-3 and ALLY-3+

Short version: slides.hcvonline.org/uploads/164/ally3.pdf
Long vesion: www.ncbi.nlm.nih.gov/pmc/articles/PMC4409820/

ALLY-3+ www.ncbi.nlm.nih.gov/pubmed/26822022

There is another bigger SOF+DCV trial here: fixhepc.com/forum/gt3/369-gt3-high-svr-r...ith-daclatasvir.html which includes a PDF of the results. It does not have a funky name AFIK.

You may notice that the results for SOF+DCV vary a bit and include similar optimistic numbers to SOF+VEL

Now this table is interesting (and you won't easily find it). It comes from Abbvie who were talking about how good G/P is (previously called ABT-493/ABT-530). GS-9857 is Voxilaprevir in case you're wondering.

In theory Velpatasvir should be better - It has an EC50 of 20 vs 530 for daclatasvir, but only about 25% gets absorbed so that robs it of part of the 26.5x theoretical edge, dropping it to say 7x, but then the dose is 100 mg vs 60 mg so that pushes it up to about 10x.

Now resistance comes in 10x, 100x and 1000x strengths so 10x is just enough to probably make a real difference for a few patients.

I have no doubt that 16 weeks SOF+DCV works better in GT3 patients than 12 weeks, so that is a factor.

Attachments:

...ort.pdf (4,214KB)

YMMV

Last Edit: 4 years 11 months ago by DrJames.

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Genotype 3's info, updates corner 4 years 11 months ago #24639

gypsy Offline Senior Member Posts: 57 Thank you received: 97 Karma: 2	I am genotype 3A and have been generic epclusa only a little over a week. My fibroscan looked normal. The first few days I felt kind of off but take it at night now and am noticing improvement in energy off and on.
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Genotype 3's info, updates corner 4 years 5 months ago #25480

MWILLIAMS Offline New Member Posts: 7 Thank you received: 12 Karma: 0	Hi I'm genotype 3 have been positive for 18 years, no scarring shown on fibroscan, no past treatment, and am about to start sofosbuvir and daclatasvir.
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Genotype 3's info, updates corner 4 years 5 months ago #25481

MWILLIAMS Offline New Member Posts: 7 Thank you received: 12 Karma: 0	MWILLIAMS wrote: Hi I'm genotype 3 have been positive for 18 years, no scarring shown on fibroscan, no past treatment, and am about to start sofosbuvir and daclatasvir.
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Genotype 3's info, updates corner 4 years 5 months ago #25482

DrJames Offline Platinum Member Posts: 1980 Thank you received: 7261 Karma: 111	Welcome MWILLIAMS, that's a good treatment. Chances are good it will cure you.
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Genotype 3's info, updates corner 4 years 5 months ago #25484

MWILLIAMS Offline New Member Posts: 7 Thank you received: 12 Karma: 0	Thanks. I've been waiting a long time for a cure and now that I have the treatment I'm a bit anxious to take it
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