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TOPIC: Post Treatment GT 3a

Post Treatment GT 3a 5 years 6 months ago #14157

Hi

I'm GT3a 6 weeks into 12 week tx. I've read some info that refers to 3a & relapse due to GT 3a being a bit tricky to clear.


Are there any GT3a's out there who were on 12wk but are now considering upping the anti and extending another 4 or so weeks as a safe guard.?

Also, how are the guys that have finished treatment feeling?
The only real side I've experienced during treatment is I a feel a little more fatigued than usual. Nothing to write home about thou, totally able to function, work etc. feel fortunate for that.

I'm not sure how to enter my stats so I've
Included some below.

No idea when I contracted. Tx Naive

Commenced treatment 25/2/16
F0
VL 62700. 4wks UND
Alt. 36. 18
Tx naive. GT3a
Female
Diagnosed 1996

Start 25/2/16
VL 62700
F0
hb 141
ALT 36
ALP 81

4 week test
VL UND
ALT 18
ALP 70

Additional 4 weeks Tx
Start 19.5.16
Last Edit: 5 years 6 months ago by Hit The Road Jack. Reason: Additional query
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Post Treatment GT 3a 5 years 6 months ago #14162

  • Gaj
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Hi HTRJ,

Your stats indicate a 97% chance of SVR which is pretty good. (G3 chances drop quickly compared to others as fibrosis increases and with prior Tx which is why I'm on the highest Tx level). I'll leave it to others with more experience of your situation to comment about extending treatment.

You may also want to consider Dr James post here though I'm not sure if it is case specific or applicable to all G3s. fixhepc.com/forum/gt3/861-alt-ast-ratio.html#14152


......to add your stats to your profile scroll to the top of this page and click on the Profile tab. Within there click on the Edit button on the right hand side and then enter your user password twice which will allow you to edit various fields including your signature panel right at the bottom of the Profile Information tab. Don't forget to Save after editing. :)
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 5 years 6 months ago by Gaj.
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Post Treatment GT 3a 5 years 6 months ago #14165

Thanks for getting back to me Gaj,
I'll have a look at Dr Freemans link. Also thanks for qik Stats entering lesson :) I'll see if I've done it correctly.

I have chatted to Dr Freeman he said an additional 4 wks wouldn't hurt for peace of mind.
I'd believe and do anything Dr James said :)
(I was more wondering if anyone else was thinking about extending)
He also said he would see what comes out of
The Liver conference . I believe this is held in Spain this year and starts on the 13 April. I read
Something about this on Dear Greg Jefferies blog. He was on his way to the conference.
Tx naive. GT3a
Female
Diagnosed 1996

Start 25/2/16
VL 62700
F0
hb 141
ALT 36
ALP 81

4 week test
VL UND
ALT 18
ALP 70

Additional 4 weeks Tx
Start 19.5.16
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Post Treatment GT 3a 5 years 6 months ago #14166

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Without knowing your full history, and based on what's in your signature you should be ok on 12 but the odds of SVR are improved significantly by longer treatment. If extending out to 16-18-24 weeks would not overburden your finances it is worth doing with GT3.
YMMV
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Post Treatment GT 3a 5 years 6 months ago #14167

thank you Dr James.
Tx naive. GT3a
Female
Diagnosed 1996

Start 25/2/16
VL 62700
F0
hb 141
ALT 36
ALP 81

4 week test
VL UND
ALT 18
ALP 70

Additional 4 weeks Tx
Start 19.5.16
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Post Treatment GT 3a 5 years 6 months ago #14175

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Hi there HTRJ -

I have a friend who is GT 3 and extending his treatment, he hasn't decided for how long, but has ordered a further 12 weeks meds. He was UND at 4 weeks and his bloods weren't as good as yours , VL higher and says he thinks he's had it 40 years+ - So this is his take on it. ie Hit it the hardest you can first time treating.

I believe some of us GT1as who have carried the virus a long time may well be a bit tricky too. My own VL was slow to come down and I am extending tx for 12 weeks. (Sofo/DAC)

I send you my very best wishes for success, you certainly have a great chance of this :)
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
Last Edit: 5 years 6 months ago by LondonGirl.
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Post Treatment GT 3a 5 years 6 months ago #14178

Hi Londongirl,

Thanks for responding.

I was originally diagnosed '96..routine tests due to unexplained fatigue. & weight loss...in hindsight the weight loss was prob due to the relationship issues I was having at the time...Anyway, I'm off track...

I will take these posts on board and go for broke....feel so lucky to have the option to extend .
Tx naive. GT3a
Female
Diagnosed 1996

Start 25/2/16
VL 62700
F0
hb 141
ALT 36
ALP 81

4 week test
VL UND
ALT 18
ALP 70

Additional 4 weeks Tx
Start 19.5.16
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Post Treatment GT 3a 5 years 6 months ago #14183

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Hi HTRJ,

I am also a slower to respond 1a and I am doing an additonal 12 weeks of Sof/Dac following 12 weeks of Sof/Led. It is likely that technically a full 24 weeks is over treatment for me but I can't deny the peace of mind factor. I am a bit conscious of the fact that I'll need to go cold turkey in a couple of weeks. B)

Wishing you all the best with your treatment.
Coral
G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24...
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Post Treatment GT 3a 5 years 6 months ago #14187

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HTRJ - I also lost alot of weight pre treatment, was positively skeletal, had fatigue, memory loss and inflamed joints, so it may not have been just stress in your case. Thankfully I've put some back on, but could do with a bit more. Yes, we are lucky to have the option to extend indeed :)

Hi Coral, how are you feeling after all those weeks of meds? I feel better on the Sofo/Dac I must say, currently rather zippy :cheer:
Yes, we get used to the comfort of the drugs I think B) Be kind to yourself #flower
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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Post Treatment GT 3a 5 years 6 months ago #14212

  • coral
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Hi LG,

I haven't really noticed very much difference between the Harvoni and now the Sof/Dac apart from the weird period of dry hair that I had on the former but who knows as it may have been caused by something else. I have been lucky with few side effects and even though I was a bit slower to respond I think I could really notice how much better I felt by 12 weeks. We are lucky to be able to do another 12 weeks but know I definately have to stop then!

Great that you are feeling better LG. Wishing you continued zippyness! :cheer:
G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24...
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Post Treatment GT 3a 5 years 6 months ago #14270

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Hi HTRJ,
I am G3a with similar stats to yours. I'm 11 weeks into treatment. From what I read, mostly here, I thought 12 weeks would be fine. I hadn't heard that people were going longer. I'm tx naïve, had fairly low VL & went UND @ 4 weeks. Your note + Dr. James' response makes me think twice though. I have the funds but I don't think I could get the next batch before EOT in 5 days. Not to mention I have a 6 day trip planned & set to leave on the day tx is done. What a drag to second guess this.
If I'd seen this a week or so ago I guess I'd probably buy more. Maybe do 4 more weèks.
Cheers
3a for 35 years
Dx 1996, tx naive, ALT 46 AST 38 VL 140K
Started Sof/Dac 1/23/16
Kingswood generics AUS
2/19/16 4wk lab HCV Undetected ALT 14 AST 19
EOT 6/1/2016
TX was 18 wks (w/some 1/2 doses & 1 skip dose after 11 wks
while waiting for +6 wks to arrive)
SVR4 6/30/16
SVR12
SVR24 Redeemed
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Post Treatment GT 3a 5 years 6 months ago #14411

Hi Mtgoat

I was just reading your post and was going to copy & paste info from Dr Freeman for you re: halving daily dose whilst u were waiting for a new order to be delivered...but I can see you found the relevant posts!!!..I hope it times well for you I.e ordering/trip away/delivery...

I've also been away..just got back which means, although I'm still 5 wks away from EOT I'll be actively looking at ordering more..just not sure whether to order an additional 4 - 8 or 12 weeks supply ... Even thou it appears it can't do any harm going full throttle I still feel a little lost on making the decision...

What did or at you thinking to do?
Tx naive. GT3a
Female
Diagnosed 1996

Start 25/2/16
VL 62700
F0
hb 141
ALT 36
ALP 81

4 week test
VL UND
ALT 18
ALP 70

Additional 4 weeks Tx
Start 19.5.16
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Post Treatment GT 3a 5 years 6 months ago #14417

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Hi Hit The Road,
Thanks for your well wishes. Timing for 1/2 doses will work out fine for my timeline. They estimated through a "Fibrosure" (blood tests) that I am F1-F2. So, even though I think 12 weeks was enough, I figure if I go another 4 weeks that's a little extra insurance. But I ordered 6 more weeks worth. I might take it all but right now I feel like 16 weeks should do it. I didn't even consider going another 12. I just think that would be overkill. For one thing, I'm a pretty small person & I figure my dosing is on the heavy side already because of it.
Cheers
3a for 35 years
Dx 1996, tx naive, ALT 46 AST 38 VL 140K
Started Sof/Dac 1/23/16
Kingswood generics AUS
2/19/16 4wk lab HCV Undetected ALT 14 AST 19
EOT 6/1/2016
TX was 18 wks (w/some 1/2 doses & 1 skip dose after 11 wks
while waiting for +6 wks to arrive)
SVR4 6/30/16
SVR12
SVR24 Redeemed
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