For me,I began taking in the morning but then I changed to nights. I didn't take with food particularly, just with water in the morning, also at night. Dac/sof does did not rely on taking with food on an empty stomach. Dac/sof seems to be absorbed differently to led/sof. I think you do need to be aware of the food contraindications however. These are documented on this site. My dac/sof was Mesochem. I did not ever experience nausea.
It works X