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TOPIC: Declatisvir and Solvadi with or without food

Declatisvir and Solvadi with or without food 5 years 6 months ago #14386

Juen
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Hi all, and to anyone experienced with taking sol/dec.

I was wondering if the solvadi and declatisvir is best taken with food .

I am taking compounding chemist meds from Kingswood Pharmacy-generics.

It seems the online researched drug companies info says with or without food is fine.

But some other forum threads on fix hep c , say to take them on an empty stomach- to get best results/absorption uptake.

I have for a 4 days been taking the meds with a medium glass of milky yogurt! -then having dinner /food an hour later.

*And no nausea etc side effects so far.

I thought to take these pills with something rather than nothing may be a good compromise i.e - to line the stomach -to maybe avoid nausea..but also not take too much food -to aid with better absorption /drug uptake.

Thank you all!
Juen

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Declatisvir and Solvadi with or without food 5 years 6 months ago #14387

pat1
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Hi Juen
For me,I began taking in the morning but then I changed to nights. I didn't take with food particularly, just with water in the morning, also at night. Dac/sof does did not rely on taking with food on an empty stomach. Dac/sof seems to be absorbed differently to led/sof. I think you do need to be aware of the food contraindications however. These are documented on this site. My dac/sof was Mesochem. I did not ever experience nausea.
It works X

gt 1a VL 6m
F2/3 FibroScan - 9KPa in 2011 and 7KPa in 2015
sof/dac 10 December for 12 weeks
pre tx alt 85 ast 51
4 wk alt 34 ast 31 UND <35
8 wk alt 29 ast 32 UND <15
12wk alt 25 ast 25 EOT 3.3.16
SVR24 UND KPa5.3 F0 in normal range
I am well
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Last Edit: 5 years 6 months ago by pat1.

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Declatisvir and Solvadi with or without food 5 years 6 months ago #14388

Gaj Offline Moderator Optimist :-) Posts: 1436 Thank you received: 3082 Karma: 32	Hi Juen, I take my Sof/Dac when I first wake in the morning then have my morning walk (45mins) to pick up milk and a paper before breakfast. While I suspect it maximises absorption, for me it means I don't forget to take them as they are first task for the day. I haven't had any issues with nausea with the Sof/dac. (Riba is different and I take those with my food)
	G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND Last Edit: 5 years 6 months ago by Gaj. The administrator has disabled public write access. The following user(s) said Thank You: Juen

Declatisvir and Solvadi with or without food 5 years 3 weeks ago #21610

Donna Offline Senior Member Posts: 71 Thank you received: 215 Karma: 3	I've been taking mine after food in the afternoon, the food was the advice of my liver nurse! What is the recommendation? It seems a good idea to have food before taking medications? Hope I've been doing the right thing....day 15 today
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Declatisvir and Solvadi with or without food 5 years 3 weeks ago #21616

beaches
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I think it depends on the meds. I had mine just before bed. That worked for me, only forgot once and got up super early because I remembered in my sleep

Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby

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Declatisvir and Solvadi with or without food 5 years 3 weeks ago #21619

Gaj
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Hi Donna,

With or without food is fine for Sofosbuvir and Daclatasvir. As I noted previously taking without food just suited my routine best and I didn't notice any problems taking them on an empty stomach. Others have felt they were better off taking with food. The only caution is in the Daclatasvir instruction sheet around taking it with a large, very high fat meal which may reduce adsorption a bit.

Effect of Food on Oral Absorption

In healthy subjects, administration of a daclatasvir 60 mg tablet after a high-fat, high-caloric meal (approximately 951 total kcal, 492 kcal from fat, 312 kcal from carbohydrates, 144 kcal from protein) decreased daclatasvir Cmax and AUC(0-inf) by 28% and 23%, respectively, compared with fasted conditions. A food effect was not observed with administration of a daclatasvir 60 mg tablet after a low-fat, low-caloric meal (approximately 277 total kcal, 41 kcal from fat, 190 kcal from carbohydrates, 44 kcal from protein) compared with fasted conditions [see Dosage and Administration (2)].

packageinserts.bms.com/pi/pi_daklinza.pdf

So as long as you don't make a habit of taking them with a Large Big Mac, thick shake and Sunday meal you will be fine either way.

G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND

Last Edit: 5 years 3 weeks ago by Gaj.

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