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TOPIC: Epclusa ... Gilead's Sofosbuvir/Valpatasvir

Epclusa ... Gilead's Sofosbuvir/Valpatasvir 5 years 4 months ago #16785

  • klhilde
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Epclusa, Gilead's Sofosbuvir/Valpatasvir combo, appears to be close to approval in Europe and the target decision date in the US is June 28.

finance.yahoo.com/news/european-chmp-ado...inion-112500863.html

Edit: Another report

www.fiercebiotech.com/biotech/new-gilead...ins-chmp-green-light

BTW ... Generic Valpatasvir is available from Mesochem. NOW.
Mesochem has Velptasvir, but Dr. Freeman has pointed out that it is not in a readily absorbable form and is therefore unsuitable for home compounding.
Last Edit: 5 years 3 months ago by klhilde.
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Epclusa ... Gilead's Sofosbuvir/Valpatasvir 5 years 3 months ago #19357

  • rohcvfighter
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Hi Everybody,

looking at the information available about Velpatasvir and Ledipasvir, we can see that both are NS5A inhibitors.

In my understanding, this means that they do action in similars ways in the replication process of the HCV virus .....

So, let's assume that one gets treated with Sofosbuvir+Ledipasvir and ...will unfortunately relapse. Does it make any sense to get treated again, but this time with Sofosbuvir+Velpatasvir?

P.S. perhaps it is a stupid question, but my logic got locked on this....

Cheers,
RHF
In fiecare an HCV ucide peste 500000 oameni.Medicamentele generice pentru hepatita C functioneaza. Nu deveni statistica! Cauta pe Google “medicamente generice pentru hepatita C”.
HCV kills more than 500000 people every year. HCV generic drugs work. Don't become a statistic.
By sharing this Youtube video you might save someone’s life!
My TX: HEPCVIR-L[generic Harvoni]-India
SVR52 achieved
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Epclusa ... Gilead's Sofosbuvir/Valpatasvir 5 years 3 months ago #19359

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I've read somewhere, that it's strong against RAVs, if I find the article, I will post.
No doubt real world results should show a truer picture?
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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Epclusa ... Gilead's Sofosbuvir/Valpatasvir 5 years 3 months ago #19365

  • mgalbrai
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Gilead's Epclusa® - European Commission Grants Marketing Authorization

hepatitiscnewdrugs.blogspot.com/2016/07/...-commission.html?m=1
This email address is being protected from spambots. You need JavaScript enabled to view it.
forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
Last Edit: 5 years 3 months ago by mgalbrai.
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Epclusa ... Gilead's Sofosbuvir/Valpatasvir 5 years 3 months ago #19412

  • DrJames
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Velpatasvir is more potent against certain RAVs

Look at it this way. RAVs are like tolerance to alcohol, so while enough beer might still make you drunk scotch will do the job faster!
YMMV
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