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TOPIC: SVR can lead to normal life expectancy for cirrhotic patients

SVR can lead to normal life expectancy for cirrhotic patients 5 years 6 months ago #16957

  • Gaj
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Survival of patients with HCV cirrhosis and sustained virologic response is similar to the general population—S Bruno et al.

Treated hepatitis C virus (HCV) cirrhotic patients can have normal life expectancy
The fact that a sustained virologic response (SVR) is associated with an improved outcome of chronic HCV infection, has been demon- strated in several studies by comparing patients with and without SVR. The study by Bruno et al., however, is the first to demonstrate that patients with compensated cirrhosis who achieve SVR will have a life expectancy similar to that of the sex- and age- matched general population. Patients were enrolled in historical prospective cohort studies from tertiary referral centers from Northern and Southern Italy. They were representative of the Italian general population, allowing for adequate comparison of patients long-term 10- and 20-year survival with national data. Intriguing observations of a trend to worse survival was observed in patients with compen- sated cirrhosis Child-Pugh class A6 as compared to A5. The incidence of hepatocellular carcinoma (HCC) during follow-up after SVR was also not negligible, underscoring the need for early treatment initiation, hereby preventing cirrhosis development as the main HCC determinant.

www.journal-of-hepatology.eu/article/S0168-8278(16)30080-0/pdf

But note the cautions regarding increased risks associated with more advanced compensated cirrhosis which indicate that early treatment is advisable.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 5 years 6 months ago by Gaj.
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SVR can lead to normal life expectancy for cirrhotic patients 5 years 6 months ago #16958

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Looks like excellent news to me. I have been wondering that- is it an extender or more of an equalizer.
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
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SVR can lead to normal life expectancy for cirrhotic patients 5 years 6 months ago #16959

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Thanks for posting that Gaj.

Cindi x
J the young dragon slayer is:
HepC 1a since birth
Male aged 15
VL 2000000
Started Twinvir/ 10-11-15-then Sof/led.
NO sides so far !
after one week VL : 37
after 4 wks VL : UND !
EOT 2/2/16 UND.!
4 wks. post tx results....pending....
7/3/16 VL result : 4 week post tx: SVR !
12 weeks SVR !
24 wks SVR yeeaa!!
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SVR can lead to normal life expectancy for cirrhotic patients 5 years 6 months ago #16973

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Excellent news indeed!
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SVR can lead to normal life expectancy for cirrhotic patients 5 years 6 months ago #16976

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How wonderful
Ty for posting the link Gaj
Treatment and prognosis options read as very encouraging
hurrah :+1: #flower :)
gt 1a VL 6m
F2/3 FibroScan - 9KPa in 2011 and 7KPa in 2015
sof/dac 10 December for 12 weeks
pre tx alt 85 ast 51
4 wk alt 34 ast 31 UND <35
8 wk alt 29 ast 32 UND <15
12wk alt 25 ast 25 EOT 3.3.16
SVR24 UND KPa5.3 F0 in normal range
I am well
.forever grateful to fixhepc
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