The U.S. Food and Drug Administration (FDA) has approved Epclusa® (sofosbuvir 400 mg/velpatasvir 100 mg), an all-oral, pan-genotypic, single tablet regimen for the treatment of adults with genotype 1-6 chronic hepatitis C virus (HCV) infection.
Good news Gaj.
Wonder what Gileads price tag will be on it?
GT1a; Got it some time in the 70's; Diagnosed @1976
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA "NOT DETECTED"
AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24!
The life you save will be your own. START TREATMENT
Thank you received: 2254
So, greediad has a presence on twitter.......
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND
12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
First born, right arm, left arm and one leg,(I'm terminally right-handed) both thumbs and big toes, life savings, or one testicle or a breast...
My bet: It will be closer to $1000 a pill than $500 or $2000.
Gilead's Mission Statement:
"Your life for your life's savings".
Preferably the latter, but....
Brought to you by pure, democratic capitalism, where the monkey's run the circus and everyone gets in free but the middle class....
This is exciting the news we were hoping for, phew! A drug that appears to
I have been lobbying, yes Gilead is all over Twitter and so are many hep activists!
Anyway here's the pipeline so far on this drug
The Business Wire link quotes Gilead’s CEO as saying:
“Today’s approval represents a significant advance for patients with HCV genotypes 2 and 3, who previously required more complex and costly regimens,” said John Milligan, Ph.D., President and Chief Executive Officer of Gilead. “As the first and only pan-genotypic cure for hepatitis C, Epclusa has the potential to eliminate the need for genotype testing, which can be a barrier to treatment in certain resource-constrained settings. We look forward to making Epclusa available to patients around the world as quickly as possible.” See:
Therefore, Epclusa (SOF + VEL) is the second pan-genotypic cure … the first to be FDA approved … only because Gilead (SOF) and Bristol-Myres Squibb (DCV) didn’t want to work together and share profits. It’s all about trying to corner the market with a one pill cure all. In other words, it’s all about maximising profits, NOT about maximising the number of HCV sufferers being cured.
Epclusa may be an advancement for difficult to cure GT3s, however, it is NOT a significant advancement for GT2s who have a very high clearance rate taking Generic SOF + DCV on this forum. All you need is Darvoni for approximately USD700 + shipping & handling for a 12 week treatment. See:
Yes GT2, keep pounding that drum! I've been pounding it for months now and I can't understand why journalists have to be so lazy as to not do a little research and instead simply accept a company's press release as gospel.
Velpatasvir may be slightly better, and it is definitely good to have alternatives for the few who need it, but Gilead's repeated statements that this is the first pan-genotypic solution are a form of deception. I wish some writer for some major news outlet would have the balls to say so.
Another one cures all DAA to hit the market shame the USD $74000 price tag means that the majority of the worlds 150 million HCV population will have a shit show in hell to get a hold of this pill. Just as well there are generic's out there right now that do the same thing for approx $1300 USD for a 12 week treatment.
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716