Welcome, Guest
Username: Password: Remember me

TOPIC: New trial study of genotype 3s

New trial study of genotype 3s 4 years 2 days ago #2892

  • Alsdad
  • Alsdad's Avatar
  • Offline
  • Moderator
  • Posts: 335
  • Thank you received: 294
  • Karma: 5
From a presentation at the latest AASLD conference:


www.hcplive.com/conference-coverage/aasl...gimen-for-genotype-3
The administrator has disabled public write access.
The following user(s) said Thank You: Jolie, Paul-Jarman-facebook, Chejai, Hit The Road Jack

New trial study of genotype 3s 4 years 2 days ago #2909

  • Jolie
  • Jolie's Avatar
  • Offline
  • Premium Member
  • Posts: 131
  • Thank you received: 111
  • Karma: 2
So, the new ALLY 3+ is different to ALLY 3 because of the sign (+) that stands for Riba addition to the double DAA tx ?

From the article:

"Hepatitis C’s genotype 3 can be hard to cure, but researchers presenting a study at the Liver Meeting (AASLD) in San Francisco, CA, said they have found a regimen that works. Vincent LeRoy, MD, of the Centre Hospitalier Universitaire de Grenoble, La Tronche France, and colleagues at other institutions reported on a trial known as ALLY-3+.

Fifty patients with HCV-GT-3 were treated and most had already had other treatments.
The patients got daclatasvir (Daklinza/Bristol-Myers-Squibb) sofosbuvir (Sovaldi/Gilead) and ribavirin (Rebetol/Merck).

One arm of the group got the combo for 12 weeks and showed SVR4 rate of 88%.
A second group took the drugs for 16 weeks and their SVR4 rate was 96%.

There were no virologic breakthroughs.

In an abstract presented at the meeting, the team concluded that the combination therapy “Achieved high SVR4 rates” in patients with HCV GT3 with compensated advanced fibrosis or cirrhosis “and was generally safe and well tolerated.”
Geno 3, Fibro 8.7 pKA, tx experinced in 2005 - Peg/Riba, relapsed.
Started tx 1/12/2015 with Indian Sofo & Chinese Dac.
5 weeks result all normal, ALT 18 - down from ALT 73 at the start of tx.
5 weeks HCV PCR RNA - UND. - down from 2 ML
9 weeks HCV PCR RNA - UND.
Last Edit: 4 years 2 days ago by Jolie.
The administrator has disabled public write access.
The following user(s) said Thank You: Chejai

New trial study of genotype 3s 4 years 1 day ago #2958

  • Paul-Jarman-facebook
  • Paul-Jarman-facebook's Avatar
  • Offline
  • Moderator
  • The gypsy woman told my mother Before I was born
  • Posts: 383
  • Thank you received: 659
  • Karma: 9
The extra 4 weeks makes a difference then ?
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
The administrator has disabled public write access.

New trial study of genotype 3s 4 years 1 day ago #2967

  • Alsdad
  • Alsdad's Avatar
  • Offline
  • Moderator
  • Posts: 335
  • Thank you received: 294
  • Karma: 5
That's what the trial appears to be saying.
The administrator has disabled public write access.

New trial study of genotype 3s 3 years 10 months ago #5506

  • Chejai
  • Chejai's Avatar
  • Offline
  • Elite Member
  • G3a 35yrsHCV
  • Posts: 272
  • Thank you received: 289
  • Karma: 1
Oh, so now I see that was what Dr James was referring to in my appointment last week. I'm G3a, F0-F1, he's prescribed the Sof/Dac but said instead of the usual 12 weeks I should do 16 weeks because the SVR4 had higher rate of success in recent research.

Thanks for that article.
QLD Australia ☀️
G3a HCV 35 yrs Tx naive
Started Sof/Dac 13/01/16

Dec '15
AST 70
ALT 89
GGT 124
Fibroscore 8.5
F1-F2
13 Feb'16 VL UND #woohoo!
AST 24
ALT 26
GGT 50H
The administrator has disabled public write access.
Time to create page: 0.123 seconds

Copyright © 2015-2019 FixHepC

Back to Top