emo New trial study of genotype 3s

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6 years 7 months ago #2892

From a presentation at the latest AASLD conference:


www.hcplive.com/conference-coverage/aasl...gimen-for-genotype-3

The following user(s) said Thank You: Jolie, Paul-Jarman-facebook, Chejai, Hit The Road Jack

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6 years 7 months ago #2909

So, the new ALLY 3+ is different to ALLY 3 because of the sign (+) that stands for Riba addition to the double DAA tx ?

From the article:

"Hepatitis C’s genotype 3 can be hard to cure, but researchers presenting a study at the Liver Meeting (AASLD) in San Francisco, CA, said they have found a regimen that works. Vincent LeRoy, MD, of the Centre Hospitalier Universitaire de Grenoble, La Tronche France, and colleagues at other institutions reported on a trial known as ALLY-3+.

Fifty patients with HCV-GT-3 were treated and most had already had other treatments.
The patients got daclatasvir (Daklinza/Bristol-Myers-Squibb) sofosbuvir (Sovaldi/Gilead) and ribavirin (Rebetol/Merck).

One arm of the group got the combo for 12 weeks and showed SVR4 rate of 88%.
A second group took the drugs for 16 weeks and their SVR4 rate was 96%.

There were no virologic breakthroughs.

In an abstract presented at the meeting, the team concluded that the combination therapy “Achieved high SVR4 rates” in patients with HCV GT3 with compensated advanced fibrosis or cirrhosis “and was generally safe and well tolerated.”


Geno 3, Fibro 8.7 pKA, tx experinced in 2005 - Peg/Riba, relapsed.
Started tx 1/12/2015 with Indian Sofo & Chinese Dac.
5 weeks result all normal, ALT 18 - down from ALT 73 at the start of tx.
5 weeks HCV PCR RNA - UND. - down from 2 ML
9 weeks HCV PCR RNA - UND.
Last Edit: 6 years 7 months ago by Jolie.
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6 years 7 months ago #2958

The extra 4 weeks makes a difference then ?


Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV

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6 years 7 months ago #2967

That's what the trial appears to be saying.

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6 years 6 months ago #5506

Oh, so now I see that was what Dr James was referring to in my appointment last week. I'm G3a, F0-F1, he's prescribed the Sof/Dac but said instead of the usual 12 weeks I should do 16 weeks because the SVR4 had higher rate of success in recent research.

Thanks for that article.


QLD Australia ☀️
G3a HCV 35 yrs Tx naive
Started Sof/Dac 13/01/16

Dec '15
AST 70
ALT 89
GGT 124
Fibroscore 8.5
F1-F2
13 Feb'16 VL UND #woohoo!
AST 24
ALT 26
GGT 50H

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