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TOPIC: generic daklinza in 100 countries?

generic daklinza in 100 countries? 5 years 11 months ago #3486

  • 2b
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Don't know if this is new news or not, but it was dated today in this article,

www.bloomberg.com/news/articles/2015-11-...py-hepatitis-c-pills
GT 2b; since 80's, no prior tx, sofosbuvir and daclatasvir compounded from API's at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. " I feel GOOD!! I knew that I WOULD!"
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generic daklinza in 100 countries? 5 years 11 months ago #3489

  • coral
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Hi 2b,

At face value it looks as if Bristol-Myer are trying to take a more reasonable, broad and humane approach to the treatment of Hep C. I imagine there must be some hurdles to jump to do any collaborating with Gillead. Good to see the increasing media focus on Hep C and the broader distribution.

Coral
G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24...
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generic daklinza in 100 countries? 5 years 11 months ago #3492

  • Gaj
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Yes, looks like it is news, and good at that.

This will allow manufacture of a combination Sofosbuvir/Daclatasvir single pill similar to Harvoni or Twinvir (Sofobuvir/Ledipasvir) which hasn't been available till now. So single pill treatments available to cover all genotypes soon now I believe.

Only for developing countries but will simplify treatment in those areas and presumably cheaper as Dac is much less expensive than Led.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 5 years 11 months ago by Gaj.
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generic daklinza in 100 countries? 5 years 11 months ago #3497

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Yes this is news.
Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
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generic daklinza in 100 countries? 5 years 11 months ago #3500

  • LondonGirl
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Hi 2b, Yes just read this on Twitter, has to be a positive :)
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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