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TOPIC: Video of Hepatitis C Virus Life Cycle

Video of Hepatitis C Virus Life Cycle 6 years 4 months ago #6272

Vororo
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From the University of Lyon:

Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
Week4: AST 47, ALT 58. VL < 15 (unquantifiable).
Week12 (EOT): AST 30, ALT 26, VL UND
Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND
Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND
Ever grateful to Dr James.

Relapsed somewhere after all that... Bummer!

Jan 2018: VL 63 000 (still GT3).

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The following user(s) said Thank You: DrJames, Archer, Joy, poodle, pat1, Chejai, sabrecat, Gaj, Tina-Hill-facebook, Jimmy6429, sonix

Video of Hepatitis C Virus Life Cycle 6 years 4 months ago #6274

Joy Offline Elite Member Posts: 218 Thank you received: 265 Karma: 0	Thanks Vororo, it's a work of art. Almost meditative...
	NSW Australia. Genotype 1b 30+ years, F0-F1, VL 91,000 Feb 2015 (740,000 in 2010), Tx naive. Ordered Sof/Dac from Buyers Club 21 Sept, received 14 Oct. Virus UNDETECTED at 3 weeks AND 12 weeks (EOT) AND SVR4 AND SVR12 AND SVR24. A thousand thankyous to Dr James and the amazing FixHepC team. The administrator has disabled public write access.

Video of Hepatitis C Virus Life Cycle 6 years 4 months ago #6276

Gaj Offline Moderator Optimist :-) Posts: 1436 Thank you received: 3082 Karma: 32	Thanks Vororo, I thought I knew a little about the subject previously but this taught me far more.......now I just need to read up on the 99% I still don't get! Seriously though, a fascinating video that gave me a better understanding of the theory behind NS4B/NS5A inhibitors, et al. Thanks G <Edit> Joy, as I was watching I thought it should have some early Pink Floyd as backing music.
	G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND Last Edit: 6 years 4 months ago by Gaj. The administrator has disabled public write access. The following user(s) said Thank You: Joy

Video of Hepatitis C Virus Life Cycle 6 years 4 months ago #6278

pat1 Offline Platinum Member Posts: 340 Thank you received: 977 Karma: 15	Thankyou Vororo The video is just amazing - it gave me a visual insight into replication factorings that are so very complex I now 'think' I understand why the new DAA's are such a scientific revelation
	gt 1a VL 6m F2/3 FibroScan - 9KPa in 2011 and 7KPa in 2015 sof/dac 10 December for 12 weeks pre tx alt 85 ast 51 4 wk alt 34 ast 31 UND <35 8 wk alt 29 ast 32 UND <15 12wk alt 25 ast 25 EOT 3.3.16 SVR24 UND KPa5.3 F0 in normal range I am well .forever grateful to fixhepc The administrator has disabled public write access.

Video of Hepatitis C Virus Life Cycle 6 years 4 months ago #6286

poodle Offline Premium Member Posts: 109 Thank you received: 188 Karma: 2	Thanks for that. I really appreciated the calming music while watching the little fellas party.!
	Geno1a 35years fibrosis 2 or 3 different results from different hospitals ?? 24weeks mesochem sof/led as unsure of fibrosis status. currently UND. No bad side effects Have svr12 ... waiting for svr 24 I now have SVR 36 weeks. The administrator has disabled public write access.

Video of Hepatitis C Virus Life Cycle 6 years 4 months ago #6322

Joan Offline Senior Member Posts: 71 Thank you received: 95 Karma: 1	Thanks for that… I didn't understand much however its given me and insight as to how complex HCV is and the incredible research that has gone into the discovery of DAA's not only for HepC but for other life threatening diseases. Science is truly remarkable.
	GT2B Diagnosed 1989 Started Tx 6.Nov.2015 F3 Fibroscan 17: April.2015 Alt PreTx: 186 Ast PreTx: 157 VL PreTx: 733,000 27.10.2015 Alt Week 4: 14 Ast Week 4: 28 VL Week 4: UND 7.12.2015 The administrator has disabled public write access.

Video of Hepatitis C Virus Life Cycle 6 years 4 months ago #6327

Archer
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Brief is life...love is long..
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It shows how NS5B, an RNA-dependent RNA polymerase, has been identified as the core of the replication complex - which possibly explains why sofosbuvir is a constant DAA throughout the treatments - working in tandem with various other inhibitors possibly selected through trial results on the basis of genotype. Of course not being educated in this field - my hypothesis could be total horse s---t. The video is superbly designed and medical training has moved to a whole new level with current technology.

Fem. Gen 1a.18.4 kPa. IL28b - CT. Cirrhosis 4B/c. MELD 11. Portal Hypertension. Ascites. Varices. (Gr.3). post surgical Coma 2011- Tx denied. 15/09 - INR 1.2 platelets 58 (150-450) albumin 32 (35-50) bilirubin 40 (2-20) ALT 183 (0-45) AST 281(0-41) GGT 39(0-45). Liver lesions AFP 16 <8.

Last Edit: 6 years 4 months ago by Archer. Reason: removed section

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