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Video of Hepatitis C Virus Life Cycle 6 years 9 months ago #6272

  • Vororo
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From the University of Lyon:

Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
Week4: AST 47, ALT 58. VL < 15 (unquantifiable).
Week12 (EOT): AST 30, ALT 26, VL UND
Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND
Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND
Ever grateful to Dr James.

Relapsed somewhere after all that... Bummer!

Jan 2018: VL 63 000 (still GT3).
The following user(s) said Thank You: DrJames, Archer, Joy, poodle, pat1, Chejai, sabrecat, Gaj, Tina-Hill-facebook, Jimmy6429, sonix

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Video of Hepatitis C Virus Life Cycle 6 years 9 months ago #6274

  • Joy
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Thanks Vororo, it's a work of art.

Almost meditative...
NSW Australia. Genotype 1b 30+ years, F0-F1, VL 91,000 Feb 2015 (740,000 in 2010), Tx naive.
Ordered Sof/Dac from Buyers Club 21 Sept, received 14 Oct.
Virus UNDETECTED at 3 weeks AND 12 weeks (EOT) AND SVR4 AND SVR12 AND SVR24. :-)
A thousand thankyous to Dr James and the amazing FixHepC team.

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Video of Hepatitis C Virus Life Cycle 6 years 9 months ago #6276

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Thanks Vororo,

I thought I knew a little about the subject previously but this taught me far more.......now I just need to read up on the 99% I still don't get! :lol:

Seriously though, a fascinating video that gave me a better understanding of the theory behind NS4B/NS5A inhibitors, et al.

Thanks
G

<Edit> Joy, as I was watching I thought it should have some early Pink Floyd as backing music. :)
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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Last edit: by Gaj.

Video of Hepatitis C Virus Life Cycle 6 years 9 months ago #6278

  • pat1
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Thankyou Vororo

The video is just amazing - it gave me a visual insight into replication factorings that are so very complex
I now 'think' I understand why the new DAA's are such a scientific revelation
gt 1a VL 6m
F2/3 FibroScan - 9KPa in 2011 and 7KPa in 2015
sof/dac 10 December for 12 weeks
pre tx alt 85 ast 51
4 wk alt 34 ast 31 UND <35
8 wk alt 29 ast 32 UND <15
12wk alt 25 ast 25 EOT 3.3.16
SVR24 UND KPa5.3 F0 in normal range
I am well
.forever grateful to fixhepc

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Video of Hepatitis C Virus Life Cycle 6 years 9 months ago #6286

Thanks for that. I really appreciated the calming music while watching the little fellas party.!
Geno1a 35years fibrosis 2 or 3 different results from different hospitals ??
24weeks mesochem sof/led as unsure of fibrosis status.
currently UND. No bad side effects
Have svr12 ... waiting for svr 24
I now have SVR 36 weeks.

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Video of Hepatitis C Virus Life Cycle 6 years 9 months ago #6322

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Thanks for that… I didn't understand much however its given me and insight as to how complex HCV is and the incredible research that has gone into the discovery of DAA's not only for HepC but for other life threatening diseases. Science is truly remarkable.
GT2B Diagnosed 1989
Started Tx 6.Nov.2015
F3 Fibroscan 17: April.2015
Alt PreTx: 186 Ast PreTx: 157 VL PreTx: 733,000 27.10.2015
Alt Week 4: 14 Ast Week 4: 28 VL Week 4: UND 7.12.2015

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Video of Hepatitis C Virus Life Cycle 6 years 9 months ago #6327

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It shows how NS5B, an RNA-dependent RNA polymerase, has been identified as the core of the replication complex - which possibly explains why sofosbuvir is a constant DAA throughout the treatments - working in tandem with various other inhibitors possibly selected through trial results on the basis of genotype. Of course not being educated in this field - my hypothesis could be total horse s---t. The video is superbly designed and medical training has moved to a whole new level with current technology.
Fem. Gen 1a.18.4 kPa. IL28b - CT. Cirrhosis 4B/c. MELD 11. Portal Hypertension. Ascites. Varices. (Gr.3). post surgical Coma 2011- Tx denied. 15/09 - INR 1.2 platelets 58 (150-450) albumin 32 (35-50) bilirubin 40 (2-20) ALT 183 (0-45) AST 281(0-41) GGT 39(0-45). Liver lesions AFP 16 <8.
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Last edit: by Archer. Reason: removed section
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