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Licorice Tea 6 years 7 months ago #11839

Hi

Hello everyone, I'm new to this site. I've noticed there have been posts recommending to avoid I'd some fruits ie grape fruit etc..I just had a Cup of licorice tea and as an after thought decided to check if it potentially inhibited CYP3A4..I think it does..my concern is has this one cup of licorice
Damaged my chances for a sussessful outcome re treatment..

It's only early days for me re commencing treatment ..Feeling worried .. I'm due to take my 3rd dose of Sol/dac tonight

Any advise would be appreciated :)
Tx naive. GT3a
Female
Diagnosed 1996

Start 25/2/16
VL 62700
F0
hb 141
ALT 36
ALP 81

4 week test
VL UND
ALT 18
ALP 70

Additional 4 weeks Tx
Start 19.5.16

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Licorice Tea 6 years 7 months ago #11840

I'm no Dr, but I wouldn't think it has harmed your chances. Especially since your intake of tea and your dose is staggered.
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James

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Licorice Tea 6 years 7 months ago #11841

Appreciate your speedy/helpful response Spit Dog...just me being jittery I guess..I received meds approx 3 weeks ago..it's taken me this long to bite the bullet and commence treatment :)
Tx naive. GT3a
Female
Diagnosed 1996

Start 25/2/16
VL 62700
F0
hb 141
ALT 36
ALP 81

4 week test
VL UND
ALT 18
ALP 70

Additional 4 weeks Tx
Start 19.5.16

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Licorice Tea 6 years 7 months ago #11842

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Hi and welcome,

Also not a Dr but with the one cup you will be fine, liquorice has been identified as a cyp3a4 inhibitor but I couldn't find anything on how strong the effect was. As splitdog says and given you are only two days into treatment that won't be a problem, just don't keep drinking it. If you search the site for "CYP3a4" you should find plenty on what items to avoid.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:

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Last edit: by Gaj.

Licorice Tea 6 years 7 months ago #11843

Jack, I'm on the same (Sof/Dac) and am on week 6. I have virtually no side effects. Are you experiencing any?
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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James

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Licorice Tea 6 years 7 months ago #11844

Just getting a response from you guys makes me feel less anxious..thanks for responding to me
Tx naive. GT3a
Female
Diagnosed 1996

Start 25/2/16
VL 62700
F0
hb 141
ALT 36
ALP 81

4 week test
VL UND
ALT 18
ALP 70

Additional 4 weeks Tx
Start 19.5.16

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Licorice Tea 6 years 7 months ago #11845

Hi Spitdog

Only 2 days in..no sides so far..(touch wood)
Tx naive. GT3a
Female
Diagnosed 1996

Start 25/2/16
VL 62700
F0
hb 141
ALT 36
ALP 81

4 week test
VL UND
ALT 18
ALP 70

Additional 4 weeks Tx
Start 19.5.16

Please Log in or Create an account to join the conversation.

Licorice Tea 6 years 7 months ago #11851

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nah, can't see one cup throwing off 12 weeks of killer meds, but like everyone else said,
Stop doing that thing!
GT 2b; since 80's, no prior tx, sofosbuvir and daclatasvir compounded from API's at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. " I feel GOOD!! I knew that I WOULD!"

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Licorice Tea 6 years 6 months ago #12668

This will have no impact.

CYP3A4 inhibitors increase the levels of Dac so it is likely to:

  1. Be equally or more effective, but
  2. Give more side effects
YMMV

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Last edit: by DrJames.
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